HUBUNGAN ANTARA HbA1c DAN KADAR LIPID SERUM DENGAN DERAJAT BERAT RETINOPATI DIABETIKA

Abstract

Diabetic retinopathy is a leading cause of blindness in industrial world and is rapidly becoming an important cause in developing countries. Many factors related with the severity of diabetic retinopathy, such as HbA1c and serum lipid. The study wants to know whether those factors have any correlation with the severity of diabetic retinopathy or not. The objective this study was to determine the correlation between HbA1c and serum lipid with the severity of diabetic retinopathy. An analytic cross sectional observational research had been done at Saiful Anwar hospital. The samples (diabetic retinopaty patients) were taken with consecutive sampling. These patient underwent funduscopy, fundus photography, laboratory examination including HbA1c, serum lipid (total serum cholesterol, LDL, HDL, triglycerides), and blood glucose. These patient were questioned about risk factors previously determined by the authors. The laboratory findings were thease are compared to the severity of diabetic retinopathy. Patient were classified into 2 group, mild and severe diabetic retinopathy. A total of 38 patients were selected, consisted of 20 males, 18 females. Nineteen patients had mild diabetic retinopathy, and the rests had severe diabetic retinopathy. Logistic regression analysis found that there was a significant correlation between HbA1c with the severity of diabetic retinopathy (p=0.017). An increases of 1% in HbA1c will result in two folds (1,995) increases, in probability of severity of diabetic retinopathy. The cut off value for HbA1c was 8.147%. The variables of total serum cholesterol (p= 0.338), LDL (p=0.241), HDL (p=0.685), and triglycerides (p=0.127) were not significant..There was significant correlation between HbA1c with the severity of diabetic retinopathy. There was no significant correlation of serum lipid with the severity of diabetic retinopathy. The higher level HbA1c influences the severity of diabetic retinopathy.

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