HtrA1: Its future potential as a novel biomarker for cancer

Altobelli, Emma; Marzioni, Daniela; Lattanzi, Amedeo; Angeletti, Paolo Matteo

doi:10.3892/or.2015.4016

Cited by 18 publications

(19 citation statements)

References 52 publications

(83 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the present data do suggest that HtrA1 may provide an important link between UCL and CRC, and that epithelium and stroma are differentially affected (41). Notably, it has been suggested that HtrA1 responds to different environments in different ways, probably due to its secretory characteristic (42), and that high HtrA1 levels are associated with chronic inflammatory conditions such as rheumatoid arthritis, osteoarthritis and macular degeneration (26,27,(43)(44)(45). The latter data appear to contrast with the decreased HtrA1 expression found in UCL, where patterns were similar to those observed in CRC.…”

Section: Low High Expression Expression -----------------------------mentioning

confidence: 45%

“…HtrA1 plays a pivotal role in the fibroblast growth factor pathway, downregulating tumour progression (24). Changes in its expression have been reported in conditions such as osteoarthritis, age-related macular degeneration and cancer (25)(26)(27). It tends to be downregulated in the metastatic foci of various tumours compared with the primary tumour in a number of malignancies, such as melanoma, sarcoma, neuroblastoma and lung cancer (23,24), while its overexpression has been hypothesized to inhibit growth and proliferation processes by acting on tumour cell apoptosis, invasiveness and migration (28).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Low HtrA1 expression in patients with long-standing ulcerative colitis and colorectal cancer

et al. 2017

Self Cite

View full text Add to dashboard Cite

The association between inflammatory bowel disease (IBD) and colorectal cancer (CRC) is being increasingly investigated. HtrA1 overexpression inhibits cell growth and proliferation by influencing apoptosis, invasiveness and migration of tumour cells. In the present study, HtrA1 expression was analysed in 228 colon tissue samples from patients with CRC, adenoma with high-grade dysplasia (AHD), adenoma with low-grade dysplasia (ALD), ulcerative colitis of >10 year duration (UCL), ulcerative colitis of <5 year duration (UCS) and colonic diverticulitis (D), and was compared with its expression in normal colon tissues (NCTs) collected 5 cm from the CRC lesion and in healthy colon mucosa (HC), to establish whether HtrA1 can serve as a biomarker for these conditions. All tissue specimens came from Italian Caucasian subjects. The main finding of the present study was that HtrA1 expression was significantly reduced in CRC and UCL tissues compared with that observed in both NCT and HC samples and with tissues from the other patients. In particular, a similar HtrA1 expression was detected in the stromal compartment of UCL and CRC samples. In contrast, the HtrA1 level was significantly lower (p=0.0008) in UCL compared with UCS tissues, suggesting an inverse relationship between HtrA1 expression and ulcerative colitis duration. HtrA1 immunostaining in the stromal compartment of AHD and ALD tissues showed no differences compared with the HC tissues. No data are available on the immunohistochemical localization of HtrA1 in CRC or IBD. The present findings suggest that HtrA1 could serve as a marker to identify UCL patients at high risk of developing CRC.

show abstract

Section: Low High Expression Expression -----------------------------mentioning

confidence: 45%

Section: Introductionmentioning

confidence: 99%

Low HtrA1 expression in patients with long-standing ulcerative colitis and colorectal cancer

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…There were 25 duplicates (figure 1); 214 papers were excluded because 28 were conference posters, 54 were reviews, 84 regarded other subjects, 30 were animal, in vitro or laboratory technique studies, and 18 evaluated blood/serum/plasma or other tissues. Examination of the remaining 50 papers in the second stage of the PRISMA flow chart led to the exclusion of 31studies for the following reasons: 5 were reviews 1,19,42-44, one assessed animals 45, 5 involved laboratory technique validation 21, 46-49, one was a molecular biology study 50, 4 were survival analysis studies 51-54, 7 assessed the impact of dietary habits 57-61, 5 did not examine urine 62-66, one reported aggregate data for CRC, gastric cancer and pancreatic cancer 67, and finally 2 did not match the inclusion criteria 68,69.…”

Section: Resultsmentioning

confidence: 99%

Role of Urinary Biomarkers in the Diagnosis of Adenoma and Colorectal Cancer: A Systematic Review and Meta-Analysis

Altobelli¹,

Angeletti²,

Latella³

2016

J. Cancer

Self Cite

View full text Add to dashboard Cite

The growing interest in enhancing and spreading colorectal cancer (CRC) screening has been stimulating the exploration of novel biomarkers with greater sensitivity and specificity than immunochemical faecal occult blood test (iFOBT). The present study provides i) a systematic review of the urinary biomarkers that have been tested to achieve early CRC diagnosis and assess the risk of colorectal adenoma and adenocarcinoma, and ii) a meta-analysis of the data regarding the urinary prostaglandin (PG) metabolite PGE-M.As regard to gene markers, we found significantly different percent methylation of the vimentin gene in CRC patients and healthy controls (HC) (p<0.0001). Respect to metabolism of nitrogenous bases, cytidine, 1-methyladenosine, and adenosine, have higher concentrations in CRC patients than in HC (respectively, p<0.01, p=0.01, and p<0.01). As regard to spermine we found that N1,N12 diacetyl spermine (DiAcSpm) and N1, N8 diacetylspermidine (DiAcSpd) were significantly higher in CRC than in HC (respectively p=0.01 and p<0.01). Respect to PGE-M, levels were higher in CRC than in those with multiple polyposis (p<0.006) and HC subjects (p<0.0004). PGE-M seems to be the most interesting and promising urinary marker for CRC and adenoma risk assessment and for CRC screening.In conclusion, evidence suggests that urinary biomarker could have a potential role as urinary biomarkers in the diagnosis of colorectal cancer. Particularly, PGE-M seems to be the most promising urinary marker for CRC early detection.

show abstract

“…In addition, endometriosis shows close similarities with neoplastic processes represented by invasion of normal tissues and metastatic growth. It is known that HtrA1 is reduced in tumours exhibiting an higher degree of malignancy, 24 , 27 , 35 suggesting an involvement of this protein in invasive processes. Interestingly, the decrease of HtrA1 in endometriosis may be a mechanism involved in the displacement of endometrial tissue outside the uterus.…”

Section: Discussionmentioning

confidence: 99%

High temperature requirement A1, transforming growth factor beta1, phosphoSmad2 and Ki67 in eutopic and ectopic endometrium of women with endometriosis

et al. 2015

View full text Add to dashboard Cite

Increasing evidence supports the hypothesis that TGFβ1 signalling may be mediated by high temperature requirement A1 (HtrA1) serine protease, acting on important regulatory mechanisms such as cell proliferation and mobility. Evidence is now accumulating to suggest that HtrA1 is involved in the development and progression of several pathologies. The aim of this study was to evaluate: i) if HtrA1 and TGFβ1 expressions differ in eutopic and ectopic endometrium in women with endometriosis; ii) if HtrA1 correlates to TGFβ1, pSmad and Ki67. This study was carried out including 10 women with ovarian endometriosis (cases) and 10 women with non endometriotic diseases (controls). Endometrial tissue underwent immunohistochemical H-score analysis for HtrA1, TGFβ1, pSmad and Ki67 molecules. Data evaluation was performed by a nonparametric Kruskal-Wallis test and Spearman correlation was applied to evaluate the relationship among the molecules investigated in the epithelial and in the stromal compartment. The HtrA1 was significantly decreased in ectopic and eutopic endometrium of women with endometriosis when compared with control endometrium in epithelial compartment. TGFβ1was significantly increased in eutopic endometrium and decreased in ectopic endometrium in epithelial and stromal compartment. In addition, Ki67 was significantly increased and an increase, but not significant, was detected for pSMAd2 in eutopic and ectopic endometrium compared to control one. In summary, the significant direct correlation between TGFβ1 and pSmad2 as well as between HtrA1 and TGFβ1 and the very significant increase of Ki67 in stromal compartment of eutopic endometrium suggest a possible involvement of HtrA1 in the pathogenesis of endometriosis.

show abstract

HtrA1: Its future potential as a novel biomarker for cancer

Cited by 18 publications

References 52 publications

Low HtrA1 expression in patients with long-standing ulcerative colitis and colorectal cancer

Low HtrA1 expression in patients with long-standing ulcerative colitis and colorectal cancer

Role of Urinary Biomarkers in the Diagnosis of Adenoma and Colorectal Cancer: A Systematic Review and Meta-Analysis

High temperature requirement A1, transforming growth factor beta1, phosphoSmad2 and Ki67 in eutopic and ectopic endometrium of women with endometriosis

Contact Info

Product

Resources

About