HTLV infection among foreign pregnant women living in Spain

Treviño, Ana; Benito, Rafael; Caballero, Estrella; Ramos, José Manuel; Parra, Patricia; Roc, Lourdes; Eirós, José María; Aguilera, Antonio; García, Juan González; Cifuentes, Carmen; Marcaida, Goitzane; Rodrı́guez, Carmen; Trigo, Matilde; Arroyo, Luis Alberto Rodríguez; Mendoza, Carmen de; Lejarazu, Raúl Ortíz de; Soriano, Vincent

doi:10.1016/j.jcv.2011.06.010

Cited by 24 publications

(14 citation statements)

References 29 publications

(37 reference statements)

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“…Prevalence rates of HTLV-1 infection in the general population are greater than 1% in the Caribbean Basin, Central Africa, and South Japan [31]. In most other areas in the world, HTLV-1/2 infections are mainly found in high-risk groups (i.e., immigrants from endemic areas, their offspring, their sexual contacts, intravenous injection users and in patients attending sexually transmitted disease clinics) [31]. Blood donors are routinely screened for HTLV-1/2 in North America, several countries in Europe, Japan, and Taiwan [31].…”

Section: Discussionmentioning

confidence: 98%

“…Human T-lymphotropic virus (HTLV) types 1-4 are retroviruses that infect humans as a result of multiple episodes of cross-species transmission from different monkey reservoirs in Central Africa [31]. HTLV-1 is known to be the etiologic agent of two well-defined diseases, adult T cell leukaemia/ lymphoma (ATLL) and HTLV-1-associated myelopathy/ tropical spastic paraparesis (HAM/TSP).…”

Section: Discussionmentioning

confidence: 99%

“…HTLV-1 is known to be the etiologic agent of two well-defined diseases, adult T cell leukaemia/ lymphoma (ATLL) and HTLV-1-associated myelopathy/ tropical spastic paraparesis (HAM/TSP). Although HTLV-2 has also occasionally been linked to neurological syndromes [31], the majority of carriers remain asymptomatic lifelong [31]. Prevalence rates of HTLV-1 infection in the general population are greater than 1% in the Caribbean Basin, Central Africa, and South Japan [31].…”

Section: Discussionmentioning

confidence: 99%

“…Although HTLV-2 has also occasionally been linked to neurological syndromes [31], the majority of carriers remain asymptomatic lifelong [31]. Prevalence rates of HTLV-1 infection in the general population are greater than 1% in the Caribbean Basin, Central Africa, and South Japan [31]. In most other areas in the world, HTLV-1/2 infections are mainly found in high-risk groups (i.e., immigrants from endemic areas, their offspring, their sexual contacts, intravenous injection users and in patients attending sexually transmitted disease clinics) [31].…”

Section: Discussionmentioning

confidence: 99%

“…In most other areas in the world, HTLV-1/2 infections are mainly found in high-risk groups (i.e., immigrants from endemic areas, their offspring, their sexual contacts, intravenous injection users and in patients attending sexually transmitted disease clinics) [31]. Blood donors are routinely screened for HTLV-1/2 in North America, several countries in Europe, Japan, and Taiwan [31]. The overall seroprevalence of HTLV infection among pregnant women in Spain is below 0.02% but increases to 0.2% with all cases found in immigrants from Latin America and Africa recommending antenatal screening in pregnant women coming from these regions [31].…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of transmissible viral disease in maternal blood samples of autologous umbilical cord blood in a private cord blood bank

Fongsarun¹,

Ekkapongpisit²,

Paisan³

et al. 2013

Transplant Technol

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Background: To provide information on the prevalence of transmissible viral disease in a Thai cohort of 2101 consecutive maternal blood samples of autologous umbilical cord blood (UCB) stored in a private cord blood bank. Materials and methods: Transmissible viral disease screening in 2101 consecutive maternal blood samples was performed serologically using the CMIA technique on an Architect i1000SR for Hepatitis B Virus (HBV) (HBsAg and Anti-HBc), Hepatitis C Virus (HCV) (anti-HCV), Human Immunodeficiency Virus (HIV) (HIV Ag/Ab Combo), Human TLymphotropic Virus type 1 and 2 (HLTV 1/2) (Anti-HTLV 1/2) and Cytomegalovirus (CMV) (CMV-IgG and CMV-IgM). Nucleic Acid Tests (NAT) were used as confirmatory tests for HBV, HIV and HCV. The prevalence of transmissible viral disease and comparisons between serological screening and NAT testing were studied and reported in this study. Results: In 2101 consecutive maternal serum samples, the positive rate of HBV-NAT was 1.62%, HCV-NAT was 0.14%, HIV-NAT was 0%, HBsAg was 2.52%, anti-HBc was 16.85%, anti-HCV was 0.33%, and HIV Ag/Ab combo was borderline but finally negative in one case. In HBsAg positive samples the positive rate of HBV-NAT was 64.15% while in anti HBc positive samples, the positive rate of HBV-NAT was 9.6%. In anti HCV positive samples, the positive rate of HCV-NAT was 42.86%. The positive rate of HTLV 1/2 was 0% and borderline in 0.19% but finally reconfirmed negative in all cases. The positive rate of CMV-IgG was 86.53% while CMV-IgM was 0.33%. Conclusions:In the present study, in a Thai cohort of maternal blood samples of autologous UCB stored in a private cord blood bank, very low prevalence of transmissible viral disease was noted. HBV, HCV and CMV prevalences were lower than observed in the general Thai population, possibly due to widespread of vaccine immunization, and the higher socioeconomic status of the mothers opting for private UCB banking. Due to our screening procedures, HIV could not be detected in any of the maternal sera. HTLV 1/2 could not be detected in any of the samples and this is the first report of its prevalence in Thailand in almost 20 years. The low prevalence of CMV IgM reinforces UCBs advantage in HSCT. The molecular biology techniques would make up for the default of the serological methods.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Prevalence of transmissible viral disease in maternal blood samples of autologous umbilical cord blood in a private cord blood bank

Fongsarun¹,

Ekkapongpisit²,

Paisan³

et al. 2013

Transplant Technol

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Current approaches for detection of human T‐lymphotropic virus Type 1: A systematic review

Fani

Rezayi

Meshkat

et al. 2019

Journal Cellular Physiology

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Background Human T‐lymphotropic virus Type 1 (HTLV‐1) is a retrovirus that is endemic in some regions of the world. It is known to cause several diseases like adult T‐cell leukemia (ATL) and HTLV‐1‐associated myelopathy/tropical spastic paraparesis (HAM/TSP). Serology and molecular methods have been used to detect this virus. Of these, enzyme‐linked immunosorbent assay (ELISA) is used as a primary screening method and this is usually followed by western blotting (WB) and polymerase chain reaction (PCR) methods as confirmatory tests. We conducted a systematic review of the different techniques used in the diagnosis of HTLV‐1 infection. Materials and Methods Our search was limited to original papers in the English language from 2010 to 2018 using several databases including Pubmed, Scopus, Google Scholar, Iranmedex, and Scientific Information Database. A manual search of references provided in the included papers was also performed. Results Of 101 electronically searched citations, 43 met the inclusion criteria. ELISA is commonly used for qualitative and screening detection, and WB and PCR techniques are used to confirm infection. Conclusion Among all the reported methods for detection of HTLV‐1, only serological and molecular tests are used as the most common technical assays for HTLV‐1. The ELISA assay, without a confirmatory test, has several limitations and affect the accuracy of the results. Owing to the prevalence of HTLV‐1 and limitations of the current detection methods, further evaluation of the accuracy of these methods is needed. There are new opportunities for applying novel technological advances in microfluidics, biosensors, and lab‐on‐a‐chip systems to perform HTLV‐1 diagnostics.

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Human T-Cell Leukemia Viruses Types 1 and 2

Murphy

Bruhn

2014

Viral Infections of Humans

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HTLV infection among foreign pregnant women living in Spain

Cited by 24 publications

References 29 publications

Prevalence of transmissible viral disease in maternal blood samples of autologous umbilical cord blood in a private cord blood bank

Prevalence of transmissible viral disease in maternal blood samples of autologous umbilical cord blood in a private cord blood bank

Current approaches for detection of human T‐lymphotropic virus Type 1: A systematic review

Human T-Cell Leukemia Viruses Types 1 and 2

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