HTLV-I transmission from mother to fetus via placenta

Fujino, Toshinori; Fujiyoshi, Toshinobu; Yashiki, Shinji; Sonoda, Shunro; Otsuka, Hiroyuki; Nagata, Yukihiro

doi:10.1016/0140-6736(92)93181-l

Cited by 32 publications

(14 citation statements)

References 5 publications

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“…Vertical transmission can occur through the placenta [Fujino et al, 1992] during gestation but it is well established that breastfeeding is the main cause of vertical transmission [Hino et al, 1985]. Thus, the seroconversion risk in children born of women infected with HTLV-1 ranges between 15.4% and 30% [Ando et al, 1889;Hino et al, 1997;Takezaki et al, 1997] but it is between 3.3% and 12.8% if such children are only formula fed [Takahashi et al, 1991;Oki et al, 1992;Ikeda et al, 1993;Ureta-Vidal et al, 1999].…”

Section: Introductionmentioning

confidence: 99%

Retrospective study of the prevalence of human T‐cell lymphotropic virus‐type 1/2, HIV, and HBV in pregnant women in Argentina

Trenchi

Gastaldello

Balangero

et al. 2007

Journal of Medical Virology

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This study shows first data on HTLV-1/2 seroprevalence among pregnant women in the non-endemic region of Argentina. In a retrospective study a representative sample (n = 3,143) of the pregnant women registered in the health public service in the province of Córdoba was evaluated. HTLV-1/2 seroprevalence was 0.191% +/- 0.0857 [IC 0.022-0.359]. This prevalence was 10 times higher in pregnant women than in blood donors [0.019 (4/21.183)]. The pregnant women would reflect the epidemiology of the general population more accurately since it constitutes a more heterogeneous group than that of blood donors. The prevalence of infection with HIV was 2.8 times higher than that of HTLV-1/2 (P < 0.05) and the presence of any of these two viruses was not a subrogating indicator of the presence of the other (Goodman and Kruskal's Tau coefficient = 0.0092). The prevalence of HBV was not significantly different from that of HTLV-1/2 (P > 0.05). We consider that it is necessary to carry out continuous studies in order to define the main risk factors for infection of these women. Thus, a decision could be made to apply the best policy in public health to prevent vertical transmission of the virus in Argentina.

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Section: Introductionmentioning

confidence: 99%

Retrospective study of the prevalence of human T‐cell lymphotropic virus‐type 1/2, HIV, and HBV in pregnant women in Argentina

Trenchi

Gastaldello

Balangero

et al. 2007

Journal of Medical Virology

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“…Reports demonstrating the presence of virus-specific antigenic or genetic components in the placenta and cord blood (Saito et al, 1991 ;Satow et al, 1991 ;Fujino et al, 1992;Katamine et al, 1994), and the antiviral humoral response in bottle-fed children (Ando et al, 1987;Tsuji et al, 1990) collectively suggest that the transplacental passage of HTLV-I infection may not be a frequent event. Given the experimental data, it is conceivable that the syncytiotrophoblast is the most important barrier against HTLV-I transmission during pregnancy.…”

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confidence: 99%

Transfer of human T cell lymphotropic virus type I to human term trophoblast cells in vitro

Liu

Zachar

Hager

et al. 1996

Journal of General Virology

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We studied the susceptibility of term placental trophoblast cells to in vitro infection with human T cell leukaemia/lymphotropic virus type I in order to provide further insight into the role of syncytiotrophoblast in transplacental passage of the virus. Pure villous trophoblast cultures were exposed to cell-free virus and the extent of infection was analysed by semiquantitative PCR assay to detect integrated proviral DNA. Four different primer pairs targeting the gag, pol, env and pX regions invariably revealed that virus sequences were present in amounts 102-103 times less than in the reference cell line MT-2. Virus expression was studied at both the transcriptional and translational levels. Whereas doubly spliced mRNAs coding for the Tax and Rex regulatory proteins could be detected by RT-PCR no virus-specific proteins were found in the cells by immunoperoxidase staining. The present data lend support to the notion that the placental trophoblast may represent a barrier effectively protecting the fetal compartment from exposure to the virus.

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“…3,8 A infecção intrauterina foi demonstrada através da comprovação histopatológica de infecção placentária em gestantes portadoras de HTLV-1 e da identificação de sequências do vírus em células mononucleares fetais obtidas no sangue do cordão umbilical. [9][10][11]…”

Section: Transmissãounclassified

Infecção pelo HTLV-1/2 em gestantes brasileiras

Barmpas

Monteiro²,

Taquette

et al. 2014

Revista Hospital Universitário Pedro Ernesto

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HTLV-1/2 são retrovírus com três vias de transmissão: sexual, hematogênica e vertical (TV). Em áreas endêmicas, a TV tem o papel principal na cadeia de transmissão, principalmente pelo aleitamento materno. A infecção é perene e 90% dos pacientes são portadores assintomáticos, porém existe associação com uma gama de doenças inflamatórias, de dermatites inespecíficas até patologias graves e de prognóstico reservado, como a leucemia/ linfoma de células T do adulto (LTA) e a mielopatia associada ao HTLV-1, ou paraparesia espástica tropical (MAH). Até hoje não existem formas de prevenção ou tratamento eficaz para a infecção por HTLV-1/2 nem para as doenças decorrentes da mesma. Os dados sobre a infecção por HTLV-1/2 em gestantes brasileiras ainda são escassos e isolados, pois a maioria dos artigos estuda doadores de sangue, a infecção não tem notificação compulsória e o rastreio não faz parte da rotina pré-natal preconizada pelo Ministério da Saúde. O objetivo deste trabalho é reunir o conhecimento disponível sobre o tema na literatura internacional. Ainda não há estudos publicados sobre a prevalência da infecção em nosso estado, mas o projeto "Estudo da prevalência e da transmissão vertical de HIV, HTLV e Sífilis em gestantes da Região Metropolitana do Rio de Janeiro", de professores da UERJ com financiamento da FAPERJ, identificou prevalência de 0,66% em parturientes na região metropolitana do Rio de Janeiro. Com base neste resultado, foi proposta a inclusão do exame para o HTLV na rotina pré-natal do HUPE/ UERJ.O melhor conhecimento sobre a prevalência de HTLV-1/2 em gestantes nas diferentes regiões brasileiras é fundamental para orientar a elaboração de políticas educacionais, sociais e de saúde pública que possam conscientizar a população sobre a doença e reduzir as taxas de transmissão vertical.

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HTLV-I transmission from mother to fetus via placenta

Cited by 32 publications

References 5 publications

Retrospective study of the prevalence of human T‐cell lymphotropic virus‐type 1/2, HIV, and HBV in pregnant women in Argentina

Retrospective study of the prevalence of human T‐cell lymphotropic virus‐type 1/2, HIV, and HBV in pregnant women in Argentina

Transfer of human T cell lymphotropic virus type I to human term trophoblast cells in vitro

Infecção pelo HTLV-1/2 em gestantes brasileiras

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