HTLV-I induces lesions in the pulmonary system: A systematic review

Normando, Valéria Marques Ferreira; Dias, Ápio Ricardo Nazareth; Lic., André Luiz Saldanha Eremita da Silva; Pinto, Denise da Silva; Santos, Márcio Clementino de Souza; Lic, Caroline Lobato Rodrigues; Oliveira, Ediléa Monteiro de; Me, Luiz Euclides Coelho de Souza Filho; Esp, Waldônio de Brito Vieira; Andriolo, Régis B; Sousa, Rita Catarina Medeiros; Falcão, Luiz Fábio Magno; Quaresma, Juarez Antônio Simões

doi:10.1016/j.lfs.2020.117979

Cited by 10 publications

(11 citation statements)

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“…The chronic hyperinflammatory cascade found in the bronchoalveolar lavage plays a critical role in the development of pulmonary changes in HTLV-1 patients, activating the recruitment and adhesion of cytokines as well as fibrosis of the lung tissue, leading to structural damage of the lungs [ 4 ]. Higher PVL is associated with lung injuries, particularly with bronchiectasis [ 5 , 7 ]; however, we did not find such association in our study. Bronchitis/bronchoalveolitis pattern was found in 30% of HTLV-1 patients with abnormal radiological findings in a Japanese study, whilst bronchiectasis were reported in 19.2% of Australian Aboriginal population with an increased mortality in younger ages associated with bronchiectasis complications [ 5 , 30 ]…”

Section: Discussioncontrasting

confidence: 99%

“…These implications should be assessed by physicians in a rehabilitation program to minimize the burden on quality of life and daily activities. Several authors have recommended lung damage screening through chest-CT scan and a detailed physical examination in HTLV-1 patients [ 3 , 7 ]…”

Section: Discussionmentioning

confidence: 99%

“…A less-explored manifestation, bronchiectasis, has been consistently reported among HTLV-1-positive patients from Australia, Japan, United Kingdom, and Brazil [ 2 , 3 , 4 ]. Other chronic lung diseases such as bronchitis and pulmonary fibrosis have also been described in HTLV-1 carriers [ 4 , 5 , 6 , 7 ]. These lesions can occur in symptomatic patients and less frequently in asymptomatic patients; however, this has hardly been recognized [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Clinical, Radiological and Functional Characteristics of Pulmonary Diseases among HTLV-1 Infected Patients without Prior Active Tuberculosis Infection

et al. 2021

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The lifelong infection with the human T lymphotropic virus type 1 (HTLV-1) has been associated with a variety of clinical manifestations; one of the less-explored is HTLV-1-associated pulmonary disease. Imaging of lung damage caused by the HTLV-1 hyperinflammatory cascade can be similar to sequelae from TB infection. Our study aims to describe the pulmonary lesions of HTLV-1-positive patients without past or current active TB and evaluate pulmonary function. We found that nine out of fourteen patients with no known TB disease history presented bronchiectasis, mainly found bilaterally while five presented pulmonary fibrosis. A normal pattern was found in most patients with a pulmonary functional test. Furthermore, there was no association between the PVL and the chest-CT scan findings, nor with spirometry results. However, the sample size was insufficient to conclude it.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical, Radiological and Functional Characteristics of Pulmonary Diseases among HTLV-1 Infected Patients without Prior Active Tuberculosis Infection

et al. 2021

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“…Since then, the VL has sought numerous markers of the immunological and inflammatory response [ 104 , 105 ] suggesting the association of genetic factors that lead to the intra-family distribution of the virus [ 106 ] and of the progression of disease in the development of HAM and other conditions of inflammatory disease among those infected with HTLV-1 [ 107 , 108 ]. Lung disease has also been reported in patients with HTLV-1 living in the state of Pará [ 109 ].…”

Section: Htlv-1/2 In the Brazilian Amazon: From Human Migration To Associated Diseasesmentioning

confidence: 99%

The Epidemiological Impact of STIs among General and Vulnerable Populations of the Amazon Region of Brazil: 30 years of Surveillance

Machado

Fonseca

Queiroz

et al. 2021

Viruses

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Sexually transmitted infections (STIs) represent a worldwide public health problem and, although many of them are curable, they continue to be neglected, especially in areas with a low human development index, such as in the northern region of Brazil. This review describes the results of 30 years of studies at the Virus Laboratory at the Federal University of Pará, including the prevalence and molecular epidemiology of HIV-1, HTLV-1/2, HPV, HBV, Treponema pallidum and Chlamydia trachomatis among urban and non-urban populations, and also in vulnerable groups in the Brazilian Amazon. Control strategies and challenges in preventing STIs are discussed considering this immense geographic region, where essential health services are unable to reach the entire population, especially the most vulnerable, such as female sex workers, people who use illicit drugs, remnants of quilombolos and indigenous communities.

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“…Desta forma, destaca-se a possibilidade do surgimento de alterações morfológicas e funcionais também no sistema respiratório, no qual decorre de um processo inflamatório ocasionado pelo vírus com infiltração linfocítica e liberação de citocinas lesivas ao tecido pulmonar [4].…”

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Uso da eletromiografia de superfície na resultância do treinamento muscular inspiratório com carga linear em portadores do vírus linfotrópico humano tipo 1

Dias¹,

Bittencourt

Gomes

et al. 2021

Fisioter Bras

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Este estudo visa avaliar por eletromiografia de superfície o comportamento dos músculos inspiratórios no treinamento muscular em voluntários com vírus linfotrópico de célula T humana do tipo 1. Trata-se de um ensaio clínico. Sete voluntários, com idade 58,85 ± 7,2) anos, realizaram treinamento muscular inspiratório domiciliar por 4 semanas, 3 vezes por semana, 30 minutos diários por meio de incentivador de carga linear. Para avaliação utilizou-se os dados de pressão inspiratória máxima e os dados da eletromiografia de superfície nas fases pré (T0), segunda semana (T2) e após a quarta semana (T4) de treinamento. Observou-se aumento progressivo da força muscular inspiratória de T0 a T4 (p = 0,007), assim como, aumento do recrutamento das unidades motoras pela análise da amplitude do sinal eletromiográfico, sendo mais evidente para o músculo esternocleidomastóideo (p = 0,12) em comparação ao músculo diafragma (p = 0,6). Verificou-se que no decurso do treinamento muscular ocorreu melhora significativa da força muscular inspiratória com maior recrutamento das fibras musculares dos músculos analisados na amostra.

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HTLV-I induces lesions in the pulmonary system: A systematic review

Cited by 10 publications

References 30 publications

Clinical, Radiological and Functional Characteristics of Pulmonary Diseases among HTLV-1 Infected Patients without Prior Active Tuberculosis Infection

Clinical, Radiological and Functional Characteristics of Pulmonary Diseases among HTLV-1 Infected Patients without Prior Active Tuberculosis Infection

The Epidemiological Impact of STIs among General and Vulnerable Populations of the Amazon Region of Brazil: 30 years of Surveillance

Uso da eletromiografia de superfície na resultância do treinamento muscular inspiratório com carga linear em portadores do vírus linfotrópico humano tipo 1

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