HTLV-1 infection-induced motor dysfunction, memory impairment, depression, and brain tissues oxidative damage in female BALB/c mice

Hedayati-Moghadam, Mahdiyeh; Rezaee, Seyed Abdolrahim; Hosseini, Mahmoud; Niazmand, Saeed; Salmani, Hossein; Rafatpanah, Houshang; Dezfuli, Milad Asarzadegan; Zabihi, Narges Amel; Abareshi, Azam

doi:10.1016/j.lfs.2018.09.031

Cited by 8 publications

(4 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Catalase hydrolyzes H2O2, and SOD is an oxidoreductase that serves to dismutate the superoxide anion (R Buettner, 2011). Our previous studies (Hedayati‐Moghadam et al, 2021; Moghadam et al, 2018) and this investigation have demonstrated that the activity of CAT and SOD in the mentioned tissue was reduced, which emphasizes the destructive role of HTLV1 infection on the free radical eradication system in vivo.…”

Section: Discussionsupporting

confidence: 64%

“…Our previous study showed that the MDA level in the brain and lungs was increased (Hedayati Moghadam et al, 2018 ). In line with this finding, we have shown that the level of MDA in the liver, kidney, and pancreas was also elevated.…”

Section: Discussionmentioning

confidence: 97%

“…This study detected provirus DNA by the TaqMan Real‐time PCR method in BALB/c mice mesenteric nodes two months after MT‐2 injection (IP). The mice peripheral blood mononuclear cells (PBMCs), mesentric nodes, and spleen tissues were used for infection confirmation in another our studies (Hedayati‐Moghadam et al, 2021; Moghadam et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that more than 90% of the virus carriers are asymptomatic (Goon et al, 2003a; Rafatpanah et al, 2007). In addition to activating inflammatory pathways, various studies show that infection with this virus is associated with increased oxidative stress and nitric oxide in plasma and various brain parts (Baydoun et al, 2015; Chaib‐Mezrag et al, 2014; Moghadam et al, 2018; Shomali et al, 2015). Oxidative stress results from an imbalance between oxidants and antioxidants in favor of oxidants.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The effect of HTLV1 infection on inflammatory and oxidative parameters in the liver, kidney, and pancreases of BALB/c mice

Niazmand

Shabgah

Hosseinian

et al. 2022

Physiological Reports

Self Cite

View full text Add to dashboard Cite

Viral infections are linked to the progression of inflammatory reactions and oxidative stress that play pivotal roles in systemic diseases. To confirm this phenomenon, in the present study, TNF‐α level and oxidative stress markers were examined in the liver, kidney, and pancreas of HTLV1‐infected male BALB/c mice. To this end, twenty BALB/c mice were divided into HTLV1‐infected mice that were inoculated with 1‐million HTLV1‐infected cells (MT‐2), and the control groups. Two months after inoculation, the peripheral blood, mesenteric lymph nodes, liver, kidney, and pancreas were collected after deep anesthetization of mice (ketamine, 30 mg/kg). The extracted DNA of mesenteric lymph nodes was obtained to quantify proviral load (PVL) using quantitative real‐time polymerase chain reaction (qRT‐PCR). The levels of lipid peroxidation, total thiol (SH), nitric oxide (NO), TNF‐α, catalase (CAT), and superoxide dismutase (SOD) activities were examined in the liver, kidney, and pancreases. Furthermore, histopathological changes in the liver and kidney were evaluated. In liver tissue, the levels of MDA, TNF‐α, and blood cell infiltration were significantly increased, and the levels of CAT and SOD were significantly decreased. In the kidney, a reduction in SOD, CAT, and total SH and an increase in MDA and NO were observed. In the pancreas, CAT activity, total SH, and SOD were decreased, and the levels of MDA and NO were enhanced. In terms of TNF‐α production, it has been shown that the level of this inflammatory cytokine was increased in the liver, kidney, and pancreas. The HTLV1 may have a role in inducing inflammatory reactions and oxidative stress pathways in the tissues.

show abstract

Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 97%