HTLV-1-associated infective dermatitis demonstrates low frequency of FOXP3-positive T-regulatory lymphocytes

Torres‐Cabala, Carlos A.; Curry, Jonathan L.; Tapia, Elsa M.L. Li Ning; Ramos, César; Tetzlaff, Michael T.; Prieto, Víctor G.; Miranda, Roberto N.; Bravo, Francisco

doi:10.1016/j.jdermsci.2015.01.003

Cited by 11 publications

(14 citation statements)

References 40 publications

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“…It shows a chronic spongiotic dermatitis with acanthosis, hyperkeratosis, parakeratosis, and mild to moderate lymphocytic infiltrates in the epidermis and dermis. A lichenoid pattern and some epidermotropism, mimicking mycosis fungoides have also been described . As in the case presented, the lymphocytic infiltrate is almost always of CD8 + predominance .…”

Section: Discussionmentioning

confidence: 99%

“…A lichenoid pattern and some epidermotropism, mimicking mycosis fungoides have also been described . As in the case presented, the lymphocytic infiltrate is almost always of CD8 + predominance . Polymerase chain reaction of skin samples detected HTLV‐1 more frequently in patients with skin disease .…”

Section: Discussionmentioning

confidence: 99%

“…Polymerase chain reaction of skin samples detected HTLV‐1 more frequently in patients with skin disease . Individuals with skin diseases associated with HTLV‐1 are thought to have an exuberant Th1 response and also have a higher proviral load than individuals without skin manifestations . A study by Setoyama et al showed by in situ hybridization that HTLV‐1 DNA is present in the epithelial lining of sweat ducts and vascular spaces.…”

Section: Discussionmentioning

confidence: 99%

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Infective dermatitis associated with HTLV‐1 infection in a girl from Trinidad: Case report and review of literature

Weiler

Mayer

Kazlouskaya

et al. 2018

Pediatric Dermatology

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Infective dermatitis (ID) associated with Human T‐cell leukemia virus type‐1 (HTLV‐1) is a rare form of severe superinfected eczema seen mostly in the Caribbean islands and Latin America. Although rapid response to antibiotic treatment is observed, patients should be monitored for development of complications associated with this retroviral infection, including T‐cell leukemia/lymphoma (ATLL) and HTLV‐1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). Infective dermatitis is rarely seen in the United States and therefore may be under‐recognized by physicians unfamiliar with this condition. Herein, we present an additional case report of an ID associated with HTLV‐1 in an 11‐year‐old girl from Trinidad.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Infective dermatitis associated with HTLV‐1 infection in a girl from Trinidad: Case report and review of literature

Weiler

Mayer

Kazlouskaya

et al. 2018

Pediatric Dermatology

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“…This disease is seen in HTLV-1 carriers, and some of the patients develop HAM/TSP. A recent study revealed that the infiltrate was composed of T cells with a predominance of CD8+ cells [8]. It is speculated that the eruptions mediated by CD8+ T cells can occur as a defensive reaction toward HTLV-1-infected cells.…”

Section: Discussionmentioning

confidence: 99%

Recurrent Facial Erythema with Cytotoxic T Cell Infiltration as a Possible Reactive Eruption in a Human T-Cell Lymphotropic Virus Type 1 Carrier

et al. 2015

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Human T-cell lymphotropic virus type 1 (HTLV-1) induces adult T cell leukemia/lymphoma (ATLL), HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and carrier. Approximately half of ATLL patients have direct skin involvement of neoplastic cells. However, there exist HTLV-1-associated reactive eruptions with a predominant infiltrate of non-neoplastic CD8+ T cells in ATLL, HAM/TSP and carrier. A 50-year-old Japanese female HTLV-1 carrier had several episodes of itchy, indurated erythema that occurred diffusely on the face and neck, lasted for 2 weeks and spontaneously subsided without sequelae. Histopathologically, CD3+ T cells infiltrated the upper dermis, and part of the infiltrating cells were CD4+CD25+, sharing the phenotype with ATLL neoplastic cells. An aggregate of CD8+ T cells bearing the cytotoxic molecule TIA-1 was also present. It is possible that skin-affinitive HTLV-1+CD4+ T cells propagated and subsequently disappeared as a result of cytotoxic T cell attack.

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“…The low frequency of Treg in HTLV-1-associated infective dermatitis is related to the maintenance of a microenvironment permissive for lymphocyte expansion and establishment of typical lesions (201). Reduced CTLA-4 and GITR expression in Treg might influence the paradoxical state defined by high Treg frequency with persistence of the inflammatory profile, which is characteristic of tropical spastic paraparesis (also known as HTLV-1-associated myelopathy) (199).…”

Section: Relevance Of Foxp3 and Treg In Pathological Conditionsmentioning

confidence: 99%

Regulatory T Cell and Forkhead Box Protein 3 as Modulators of Immune Homeostasis

et al. 2017

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The transcription factor forkhead box protein 3 (FOXP3) is an essential molecular marker of regulatory T cell (Treg) development in different microenvironments. Tregs are cells specialized in the suppression of inadequate immune responses and the maintenance of homeostatic tolerance. Studies have addressed and elucidated the role played by FOXP3 and Treg in countless autoimmune and infectious diseases as well as in more specific cases, such as cancer. Within this context, the present article reviews aspects of the immunoregulatory profile of FOXP3 and Treg in the management of immune homeostasis, including issues relating to pathology as well as immune tolerance.

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HTLV-1-associated infective dermatitis demonstrates low frequency of FOXP3-positive T-regulatory lymphocytes

Cited by 11 publications

References 40 publications

Infective dermatitis associated with HTLV‐1 infection in a girl from Trinidad: Case report and review of literature

Infective dermatitis associated with HTLV‐1 infection in a girl from Trinidad: Case report and review of literature

Recurrent Facial Erythema with Cytotoxic T Cell Infiltration as a Possible Reactive Eruption in a Human T-Cell Lymphotropic Virus Type 1 Carrier

Regulatory T Cell and Forkhead Box Protein 3 as Modulators of Immune Homeostasis

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