Regulatory T Cell and Forkhead Box Protein 3 as Modulators of Immune Homeostasis

Pereira, Leonn Mendes Soares; Gomes, Samara Tatielle Monteiro; Ishak, Ricardo; Vallinoto, Antônio Carlos Rosário

doi:10.3389/fimmu.2017.00605

Cited by 83 publications

(63 citation statements)

References 339 publications

(361 reference statements)

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“…This occurs through direct cell-to-cell contact [10] , secretion of multiple inhibitory cytokines such as transforming growth factor-β (TGF-β), interleukin (IL)-10, and through inhibiting the production of interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) [15] . These actions cumulatively exert an immunosuppressive effect on the body's defenses [11] . FOXP3 is a member of the forkhead/winged-helix transcription factor family.…”

Section: Discussionmentioning

confidence: 99%

“…Treg generally refers to regulatory CD3 + CD4 + CD25 + FOXP3 + T cells. These cells can have immunosuppressive effects through activation and expression of a variety of immune cells by cell-cell contact and cytokine-mediated mechanisms [10,11] . FOXP3 is the speci c marker of Tregs and is the key to their development, activation, and function [12,13] .…”

Section: Introductionmentioning

confidence: 99%

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Effect of Intraoperative Blood Transfusion On Treg And Foxp3 In Patients With Digestive Tract Malignancies And Different Abo Blood Types

Liu¹,

Sun²,

Xia

et al. 2020

Preprint

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Background Blood transfusion can cause immunosuppression and lead to worse outcomes in patients with digestive tract malignancies; however, the specific mechanism behind this is not completely understood. One theory is that increased numbers of regulatory CD3 + CD4 + CD25 + FOXP3 + T cells (Tregs) and forkhead box protein-3 mRNA (FOXP3) expression in the blood after transfusion contribute to these outcomes. The effect of blood transfusion on immune function in patients with different ABO blood types is variable. This study investigates the effect of intraoperative blood transfusion on the number of Tregs and the expression of FOXP3 in the blood of patients with different ABO blood types and digestive tract malignancies. Methods Patients with digestive tract malignancies who underwent radical resection and received intraoperative blood transfusion were divided into four groups according to their blood types:blood group A, B, O and AB (n=20 ). Blood was collected before surgery, immediately after transfusion, 1 day after transfusion, and 5 days after transfusion. The number of Tregs was measured by flow cytometry. The expression of FOXP3 was detected by real time reverse transcription polymerase chain reaction (RT-PCR). Results There was no significant difference in the number of Tregs or expression of FOXP3 mRNA among patients with different blood types before surgery. However, the number of Tregs and the expression of FOXP3 increased after blood transfusion in all blood type groups. This increase was especially evident and statistically significant on the first day after blood transfusion when compared with measures obtained before the surgery. Measures returned to the preoperative level five days after surgery. There were significant differences in the increase of Tregs and expression of FOXP3 among patients with different blood types. The greatest increase was seen in patients with blood group B and the least in blood group A. Conclusions Intraoperative blood transfusion can lead to an increase in blood Tregs and FOXP3 expression in patients with digestive tract malignancies. Increases were greatest on the first day after surgery and differed among patients with different blood types. Increases were greatest in blood type B and least in blood type A.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Intraoperative Blood Transfusion On Treg And Foxp3 In Patients With Digestive Tract Malignancies And Different Abo Blood Types

Liu¹,

Sun²,

Xia

et al. 2020

Preprint

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“…Once recognition occurs, Tregs in the thymus undergo deletional apoptosis . Tregs located in the embryo's peripheral lymphoid tissues also induce immune tolerance . B‐lymphocyte clones undergo similar processes of self‐recognition and clonal deletion.…”

Section: Natural Chimeras Exhibit Immune Tolerancementioning

confidence: 99%

A review of the biology and classification of human chimeras

Wenk¹

2018

Transfusion

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Many human chimeras remain undetected. The states of health and disease of human chimeras remain largely unknown. Of four ways to detect human chimeras, molecular typing is the most sensitive and specific. Before systematic and temporal studies can be undertaken, improved cell sampling and better analytical detection methods are necessary. Chimeras may be sought among dizygotic twins and children born after IVF procedures.

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“…The transcriptional factors bind to conserved non-coding sequences (CNS) in intronic regions; this mechanism ensures transcription of FOXP3 gene [12]. Polymorphisms of FOXP3 gene regulatory regions of FOXP3 gene may alter gene expression and Tregs function [13]. It has been reported, that rs2232365 (A to G) polymorphism, which is speci c to the FOXP3 gene regulatory regions, is associated with immunologic diseases [14] and Treg function regulation.…”

Section: Introductionmentioning

confidence: 99%

Contribution of rs2232365 Polymorphism of FOXP3 Gene in Cervical Cancer Development

Kldiashvili

Metreveli

2020

Preprint

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Objective Cervical cancer is the second common malignancy in women. This is an immunogenic malignancy, and high-risk human papilloma virus (HPV) subtypes may cause its development. Persistent infection of high-risk HPV subtypes may significantly facilitate the development of cervical intraepithelial neoplasia, which has been confirmed as a major risk factor of cervical cancer. Regulatory T cells (Treg cells) are a group of mature T cells generated in the thymus following the induction of peripheral naïve T cells. They are essential for the inhibition of immune overreaction induced damage, but over-production of Treg cells may block the protective immune response to infection and tumors. FOXP3 (Forkhead box protein P3) is a key transcription factor in regulatory T cells (Tregs), and has important roles in the immunosuppressive functions in Tregs. The role of FOXP3 gene polymorphisms in cancer patients is not determined till now. Results We have investigated the association of rs2232365 (A to G) of FOXP3 gene with cervical cancer. rs2232365A/G polymorphism has been detected in cervical cancer (25 cases, 73.53% of cancer cases, p=0.03) and CIN (36 cases, 64.29% of CIN cases, p=0.02). We assume that rs2232365 polymorphism of the Foxp3 gene may contribute to the cervical cancer development.

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Regulatory T Cell and Forkhead Box Protein 3 as Modulators of Immune Homeostasis

Cited by 83 publications

References 339 publications

Effect of Intraoperative Blood Transfusion On Treg And Foxp3 In Patients With Digestive Tract Malignancies And Different Abo Blood Types

Effect of Intraoperative Blood Transfusion On Treg And Foxp3 In Patients With Digestive Tract Malignancies And Different Abo Blood Types

A review of the biology and classification of human chimeras

Contribution of rs2232365 Polymorphism of FOXP3 Gene in Cervical Cancer Development

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