HT7, Neurothelin, Basigin, gp42 and OX-47 - many names for one developmentally regulated immuno-globulin-like surface glycoprotein on blood-brain barrier endothelium, epithelial tissue barriers and neurons

Seulberger, Harald; Unger, Carolin; Risau, Werner

doi:10.1016/0304-3940(92)90690-9

Cited by 91 publications

(49 citation statements)

References 18 publications

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“…CD147 was identified independently in various species and are referenced throughout the literature as EMMPRIN (Extracellular Matrix Metalloproteinase-Inducer), M6 (Human) (Kasinrerk et al 1992), Neurothelin, 5A11 and HT7 (chicken) (Seulberger et al 1992;Fadool et al 1993;Schlosshauer et al 1995), OX47 and CE9 (rat) (Fossum et al 1991;Nehme et al 1995), and Basigin, gp42 (human and mouse) (Altruda et al 1989;Miyauchi et al 1991;Miyauchi et al 1995). The CD147 gene, designated BSG for basigin, is located on chromosome 19p13.3 and encodes a 29 kD protein, though migration on SDS-PAGE usually occurs between 35-65 kD, depending on the degree of glycosylation (Kasinrerk et al 1992;Kirsch et al 1997;Kasinrerk et al 1999).…”

Section: Structural Organizationmentioning

confidence: 99%

CD147 immunoglobulin superfamily receptor function and role in pathology

Iacono

Brown

Greene

et al. 2007

Experimental and Molecular Pathology

243

206

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The immunoglobulin superfamily member CD147 plays an important role in fetal, neuronal, lymphocyte and extracellular matrix development. Here we review the current understanding of CD147 expression and protein interactions with regard to CD147 function and its role in pathologic conditions including heart disease, Alzheimer's disease, stroke and cancer. A model linking hypoxic conditions found within the tumor microenvironment to up-regulation of CD147 expression and tumor progression is introduced.

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Section: Structural Organizationmentioning

confidence: 99%

CD147 immunoglobulin superfamily receptor function and role in pathology

Iacono

Brown

Greene

et al. 2007

Experimental and Molecular Pathology

243

206

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“…MCT1 and MCT4 are closely associated with the monotopic membrane protein CD147 (8,9). This protein is a widely distributed member of the immunoglobulin superfamily (10,11) and appears to act as a chaperone that is essential for the correct targeting of MCT1 and MCT4 to the plasma membrane.…”

mentioning

confidence: 99%

Expression and Distribution of Lactate/Monocarboxylate Transporter Isoforms in Pancreatic Islets and the Exocrine Pancreas

et al. 2001

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“…Examples of this behavior include Na,K-ATPase (Miller et al, 1978;Okami et al, 1990;Gundersen et al, 1991), neural cell adhesion molecule (NCAM; Gundersen et al, 1993), monocarboxylate transporter 1 (Philp et al, 1998), and CD147 (Marmorstein et al, 1996). CD147, a type I membrane protein and a member of the immunoglobulin superfamily (Stockinger et al, 1997), has been independently cloned from different species and is also referred to as human EMMPRIN/M6 (Biswas et al, 1995), mouse basigin (Miyauchi et al, 1990), chicken 5A11 (Fadool and Linser, 1993a), avian HT7 (Seulberger et al, 1992), and rat CE-9 (Nehme et al, 1993). Mice with targeted disruption of the CD147 gene are blind starting 5 weeks after birth (Hori et al, 2000) because of deficient photoreceptor development and retinal degeneration (Ochrietor et al, 2001(Ochrietor et al, , 2002.…”

Section: Introductionmentioning

confidence: 99%

The Basolateral Targeting Signal of CD147 (EMMPRIN) Consists of a Single Leucine and Is Not Recognized by Retinal Pigment Epithelium

Deora

Gravotta

Kreitzer

et al. 2004

MBoC

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CD147, a type I integral membrane protein of the immunoglobulin superfamily, exhibits reversed polarity in retinal pigment epithelium (RPE). CD147 is apical in RPE in contrast to its basolateral localization in extraocular epithelia. This elicited our interest in understanding the basolateral sorting signals of CD147 in prototypic Madin-Darby canine kidney (MDCK) cells. The cytoplasmic domain of CD147 has basolateral sorting information but is devoid of well-characterized basolateral signals, such as tyrosine and di-leucine motifs. Hence, we carried out systematic site-directed mutagenesis to delineate basolateral targeting information in CD147. Our detailed analysis identified a single leucine (252) as the basolateral targeting motif in the cytoplasmic tail of CD147. Four amino acids (243-246) N-terminal to leucine 252 are also critical basolateral determinants of CD147, because deletion of these amino acids leads to mistargeting of CD147 to the apical membranes. We ruled out the involvement of adaptor complex 1B (AP1B) in the basolateral trafficking of CD147, because LLC-PK1 cells lacking AP1B, target CD147 basolaterally. At variance with MDCK cells, the human RPE cell line ARPE-19 does not distinguish between CD147 (WT) and CD147 with leucine 252 mutated to alanine and targets both proteins apically. Thus, our study identifies an atypical basolateral motif of CD147, which comprises a single leucine and is not recognized by RPE cells. This unusual basolateral sorting signal will be useful in unraveling the specialized sorting machinery of RPE cells. INTRODUCTIONEpithelial cells have distinct apical and basolateral membrane domains with different protein and lipid compositions. The asymmetry is essential for the multiple vectorial functions they perform (Rodriguez-Boulan and Nelson, 1989;Yeaman et al., 1999). The polarized protein distribution results from sorting mechanisms operating in the biosynthetic and recycling pathways that recognize specific sorting signals in plasma membrane proteins. Structural features believed to operate as apical sorting signals include glycosylphophatidylinositol anchors (Lisanti et al., 1989), N-glycans (Scheiffele et al., 1995), O-glycans (Yeaman et al., 1997;Jacob et al., 2000), and protein sequences in the transmembrane (Kundu et al., 1996;Lin et al., 1998), or cytoplasmic domains (Chuang and Sung, 1998;Rodriguez-Boulan and Gonzalez, 1999;Nelson and Yeaman, 2001). On the other hand, basolateral signals are formed by short peptide sequences usually found in the protein domain facing the cytosol (Le Gall et al., 1995;Yeaman et al., 1999;Mostov et al., 2000). They mainly include tyrosine motifs (consensus motif NPXY or YXXF) as well as di-leucine and di-hydrophobic residues (Matter et al., 1992;Aroeti et al., 1993;Hunziker and Fumey, 1994;Simonsen et al., 1997;Bonifacino and Dell'Angelica, 1999;Rodionov et al., 2000).Different types of epithelial cells vary widely in the final distribution of plasma membrane proteins or in the pathways that these proteins follow to the cell surf...

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HT7, Neurothelin, Basigin, gp42 and OX-47 - many names for one developmentally regulated immuno-globulin-like surface glycoprotein on blood-brain barrier endothelium, epithelial tissue barriers and neurons

Cited by 91 publications

References 18 publications

CD147 immunoglobulin superfamily receptor function and role in pathology

CD147 immunoglobulin superfamily receptor function and role in pathology

Expression and Distribution of Lactate/Monocarboxylate Transporter Isoforms in Pancreatic Islets and the Exocrine Pancreas

The Basolateral Targeting Signal of CD147 (EMMPRIN) Consists of a Single Leucine and Is Not Recognized by Retinal Pigment Epithelium

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