Hsp90 up-regulates PD-L1 to promote HPV-positive cervical cancer via HER2/PI3K/AKT pathway

Zeng, Jie; He, Songlin; Li, Lijie; Wang, Chen

doi:10.1186/s10020-021-00384-2

Cited by 22 publications

(12 citation statements)

References 41 publications

(36 reference statements)

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“…It has been demonstrated that the PI3K/AKT pathway is an important cellular signaling pathway involved in a variety of cellular activities, including cell migration, proliferation, and survival (W. Dong et al, 2018 ; Guo et al, 2021 ; Zeng, He, Li, & Wang, 2021 ). Previous studies have indicated that PI3K could aggravate impairment of HUVECs and angiogenesis, indicating a potential target for wound healing ( Hunter et al, 2019 ; M.; Zhang et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Urolithin A Promotes Angiogenesis and Tissue Regeneration in a Full-Thickness Cutaneous Wound Model

et al. 2022

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The treatment of chronic wound is an important topic of current clinical issue. Neovascularization plays a crucial role in skin wound healing by delivering fresh nutrients and oxygen to the wound area. The aim of this study was to investigate the mechanisms of urolithin A (UA) in angiogenesis during wound healing. The results of in vitro experiments showed that treatment with UA (5–20 μM) promoted the proliferation, migration, and angiogenic capacity of HUVECs. Furthermore, we investigated the effect of UA in vivo using a full-thickness skin wound model. Subsequently, we found that UA promoted the regeneration of new blood vessels, which is consistent with the results of accelerated angiogenesis in vitro experiments. After UA treatment, the blood vessels in the wound are rapidly formed, and the deposition and remodeling process of the collagen matrix is also accelerated, which ultimately promotes the effective wound healing. Mechanistic studies have shown that UA promotes angiogenesis by inhibiting the PI3K/AKT pathway. Our study provides evidence that UA can promote angiogenesis and skin regeneration in chronic wounds, especially ischemic wounds.

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Section: Discussionmentioning

confidence: 99%

Urolithin A Promotes Angiogenesis and Tissue Regeneration in a Full-Thickness Cutaneous Wound Model

et al. 2022

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“…Consistent with our results, Hsp90 levels did not vary in lobular neoplasia of the breast [ 61 ], while Hsp90 positive cells were significantly increased in invasive breast carcinoma [ 62 ], again indicating a role of Hsp90 in promoting malignancy. Hsp90 overexpression has been documented as a potential diagnostic marker in hepatocellular carcinoma [ 63 ]; cervical [ 64 ], colorectal [ 65 ], and breast [ 62 ] cancers; melanomas [ 66 ]; leiomyosarcomas [ 66 ]; gastrointestinal stromal tumors (GIST) [ 66 ]; and malignant peripheral nerve sheath tumors [ 66 ]. Tissue Hsp90 up-regulation was correlated with higher risk GIST and extragastric locations, and served as an independent predictor of recurrence in patients with GIST after complete surgical resection [ 66 ].…”

Section: Discussionmentioning

confidence: 99%

“…The combined inhibition of Hsp90 and CDC37 was efficient in abrogating the phosphorylation of Akt in mutant BRAF colon cancer cells [ 82 ]. Conversely, other studies highlight the suppression of cellular proliferation, migration, and progression through deactivation of the PI3K/Akt pathway by Hsp90 knockdown or inhibition in colorectal [ 96 ], gastric [ 97 ], osteosarcoma [ 98 ], ovarian [ 99 ] and cervical [ 64 ] cancers. The discrepancy in the results may lie in the type of tissue, type of cancer and the cell lines that were used.…”

Section: Discussionmentioning

confidence: 99%

The Chaperone System in Salivary Glands: Hsp90 Prospects for Differential Diagnosis and Treatment of Malignant Tumors

Basset

Rappa

Barone

et al. 2022

IJMS

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Salivary gland tumors represent a serious medical problem and new tools for differential diagnosis and patient monitoring are needed. Here, we present data and discuss the potential of molecular chaperones as biomarkers and therapeutic targets, focusing on Hsp10 and Hsp90. The salivary glands are key physiological elements but, unfortunately, the information and the means available for the management of their pathologies, including cancer, are scarce. Progress in the study of carcinogenesis has occurred on various fronts lately, one of which has been the identification of the chaperone system (CS) as a physiological system with presence in all cells and tissues (including the salivary glands) that plays a role in tumor-cell biology. The chief components of the CS are the molecular chaperones, some of which belong to families of evolutionarily related molecules named heat shock protein (Hsp). We are quantifying and mapping these molecular chaperones in salivary glands to determine their possible role in the carcinogenetic mechanisms in these glands and to assess their potential as diagnostic biomarkers and therapeutic targets. Here, we report recent findings on Hsp10 and Hsp90 and show that the quantitative and topographic patterns of tissue Hsp90 are distinctive of malignant tumors and differentiate benign from malignant lesions. The Hsp90 results show a correlation between quantity of chaperone and tumor progression, which in turn calls for negative chaperonotherapy, namely, elimination/inhibition of the chaperone to stop the tumor. We found that in vitro, the Hsp90 inhibitor Ganetespib is cytotoxic for the salivary gland UM-HACC-2A cell line. The drug, by interfering with the pro-survival NF-κB pathway, hampers cellular proliferation and migration, and favors apoptosis, and can, therefore, be considered a suitable candidate for future experimentation to develop a treatment for salivary gland tumors.

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“…Studies have shown that HSP90 binds to a variety of cell surface receptors and triggers signalling pathways that lead to malignancy. Zheng et al found that HSP90 can interact with HER2 to activate the PI3K/AKT signalling pathway thereby upregulating PD‐L1 expression and promoting cervical carcinogenesis (Zeng et al, 2021). Zhang et al found that inhibition of HSP90 inhibits HIF‐1α/VEGF/VEGFR‐2 mediated angiogenesis (Zhang et al, 2020).…”

Section: Classification and Structure Of Hsp90mentioning

confidence: 99%

Advances in the role of heat shock protein 90 in prostate cancer

Jia

2022

Andrologia

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Prostate cancer is one of the most common tumours in adult men and heat shock proteins play an important biological function in prostate cancer as molecular chaperones involved in the pathogenesis, diagnosis, treatment and prognosis of a wide range of tumours. Among them, increased expression of HSP90, a member of the heat shock protein family, is associated with resistance to prostate cancer denervation and can promote tumour resistance, invasion and bone metastasis, thus making prostate cancer more difficult to treat. Therefore, targeting HSP90 in prostate cancer could be a promising strategy for oncology treatment. This paper reviews the structure and function of HSP90, HSP90‐mediated denudation resistance in prostate cancer and HSP90‐targeted antitumor therapy, with the aim of providing a new theoretical basis for prostate cancer treatment options in the clinical setting.

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Hsp90 up-regulates PD-L1 to promote HPV-positive cervical cancer via HER2/PI3K/AKT pathway

Cited by 22 publications

References 41 publications

Urolithin A Promotes Angiogenesis and Tissue Regeneration in a Full-Thickness Cutaneous Wound Model

Urolithin A Promotes Angiogenesis and Tissue Regeneration in a Full-Thickness Cutaneous Wound Model

The Chaperone System in Salivary Glands: Hsp90 Prospects for Differential Diagnosis and Treatment of Malignant Tumors

Advances in the role of heat shock protein 90 in prostate cancer

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