HSP70-2 (HSPA1B) is Associated with Noncognitive Symptoms in Late-Onset Alzheimer's Disease

Clarimón, Jordi; Bertranpetit, Jaume; Boada, Merçé; Tárraga, Lluís; Comas, David

doi:10.1177/0891988703256051

Cited by 37 publications

(27 citation statements)

References 41 publications

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“…It is also involved in the ubiquitin-proteasome pathway. This finding is consistent with our previous association study about associations between Hsp and SZ [1] , and with other findings in the literature, both focused on SZ [53,54] and on other neurological disorders, such as the positive correlation between HSPA1B variations and noncognitive symptoms in patients suffering from Alzheimer's disease [55] . This further evidence of association between SZ and HSPA1B strengthens the hypothesis that this Hsp might be involved in the pathophysiology of SZ.…”

Section: Discussionsupporting

confidence: 82%

The Impact of Heat Shock Protein 70 Gene Variations on Clinical Presentation and Outcome in Schizophrenic Inpatients

et al. 2009

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We previously investigated a group of single-nucleotide polymorphisms of a set of genes coding for heat shock proteins (HSPA1A, HSPA1B and HSPA1L) and found a significant association between one HSPA1B variation and schizophrenia (SZ). We now report an association between a set of variations (rs2227956, rs2075799, rs1043618, rs562047 and rs539689) within the same genes and a larger sample of schizophrenic inpatients. A single variation, rs539689 (HSPA1B), was found to be marginally associated with Positive and Negative Syndrome Scale (PANSS) positive scores at discharge, and haplotype analysis revealed a significant association between improvement in PANSS scores with both A-C-G-G and A-C-G-G haplotypes. These findings further support a role of heat shock proteins in the pathophysiology of SZ.

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Section: Discussionsupporting

confidence: 82%

The Impact of Heat Shock Protein 70 Gene Variations on Clinical Presentation and Outcome in Schizophrenic Inpatients

et al. 2009

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“…There are only a few investigations regarding the possible role of hsp70-2 in some diseases; for example, BougachaElleuch et al (2000) indicated that there was lack of association between hsp-2 polymorphism and autoimmune thyroid diseases. Clarimon et al (2003) found that the severity of behavioral disturbances in patients with Alzheimer's disease carrying 1 or 2 hsp70-2 deletion alleles was higher for those patients carrying the hsp70-2 insertion. Fekete et al (2003) reported that the hsp70-2 GG genetic variation was associated with low inducibility of HSP70 and with the increased risk of acute renal failure in very low birth weight neonates.…”

Section: Discussionmentioning

confidence: 93%

Association of hsp70-2 and hsp-hom gene polymorphisms with risk of acute high-altitude illness in a Chinese population

Fang

Wang

Li³

et al. 2005

Cell Stress Chaper

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High-altitude illness (HAI) is a potentially fatal condition involving genetic and environmental components. Accumulated experimental evidence suggests that heat shock proteins (Hsps), especially HSP70, can protect cells and organs against different types of damage. We investigated whether genetic variation in constitutive and inducible hsp70 genes could be associated with risk of HAI. The association between polymorphisms of the HSP70 family genes and risk of HAI was determined in 56 patients with HAI and in 100 matched controls by genotyping for the polymorphisms ϩ190 G/C, ϩ1267 A/G, 2437 G/C in the hsp70-1, hsp70-2, and hsp70-hom genes by using polymerase chain reaction-restriction fragment length polymorphism. The data showed that there was no statistically significant difference in the genotype and allele distributions of hsp70-1, in hsp70-2 allele and hsp70-2 A/A and A/B genotypes, and in allele distribution of hsp70-hom among patients with HAI and controls ( 2 test, P Ͼ 0.05). However, there was a significantly higher frequency of hsp70-2 B/B and hsp70-hom A/A and B/B genotypes and a significantly lower frequency of the hsp70-hom A/B genotype in the HAI patients compared with the controls (P Ͻ 0.05 for all). The risk associated with the hsp70-2 B/B and hsp70-hom A/A, A/B, and B/B genotypes were 4.017 (95% CI ϭ 1.496-10.781; P ϭ 0.004), 2.434 (95% CI ϭ 1.184-5.003; P ϭ 0.012), 0.299 (95% CI ϭ 0.148-0.602, P ϭ 0.001), and 5.880 (95% CI ϭ1. 145-30.196, P ϭ 0.026), respectively. Our results suggest that individuals with hsp70-2 B/B and hsp70-hom A/B and B/B genotypes may be more susceptible to HAI, whereas those with hsp70-hom A/B genotype may be tolerant to HAI. Further studies in individuals of different age and sex are warranted to elucidate the underlying mechanisms of this association and the possible functions of different genotypes of hsp70-2 and hsp70-hom under hypoxic stress.

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“…The possible role of HSP70-2 gene polymorphism in various diseases has been reported previously [20][21][22][23]. Although this polymorphism does not alter the amino acid sequence of HSP70-2 protein, previous studies have shown that different genotypes of HSP70-2 are associated with different levels of mRNA expression [22].…”

Section: Discussionmentioning

confidence: 94%

Protective Role of Genetic Polymorphism of Heat Shock Protein 70-2 for Gastric Cancer Risk

et al. 2008

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HSP70-2 (HSPA1B) is Associated with Noncognitive Symptoms in Late-Onset Alzheimer's Disease

Cited by 37 publications

References 41 publications

The Impact of Heat Shock Protein 70 Gene Variations on Clinical Presentation and Outcome in Schizophrenic Inpatients

The Impact of Heat Shock Protein 70 Gene Variations on Clinical Presentation and Outcome in Schizophrenic Inpatients

Association of hsp70-2 and hsp-hom gene polymorphisms with risk of acute high-altitude illness in a Chinese population

Protective Role of Genetic Polymorphism of Heat Shock Protein 70-2 for Gastric Cancer Risk

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