Association of hsp70-2 and hsp-hom gene polymorphisms with risk of acute high-altitude illness in a Chinese population

Fang, Zhou; Wang, Feng; Li, Fangze; Yuan, Jing; Zeng, Huasong; Wei, Qingyi; Tanguay, Robert M.; Wu, Tangchun

doi:10.1379/csc-156.1

Cited by 48 publications

(28 citation statements)

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“…In ankylosing spondylitis, differences in hsp70-1 and hsp70-2 genotypes among ankylosing spondylitis patients and controls appear to be due to the linkage disequilibrium between HSP70 alleles and HLA-B*27 (Fraile et al 1998). We also found that individuals with hsp70-2 ϩ1267B/B, hsp70-hom ϩ2437A/B, ϩ2437B/B genotypes are more susceptible to high-altitude illness, whereas those with hsp70-hom ϩ2437A/B genotype are tolerant to low oxygen (Zhou et al 2005).…”

Section: Discussionmentioning

confidence: 48%

“…These genes are polymorphic, potentially accounting for variation in their functions and susceptibility to stress tolerance (Favatier et al 1997;Wu et al 2004). Some studies reported possible associations of single nucleotide polymorphisms (SNPs) in the hsp70 genes with Parkinson's disease (Wu et al 2004), abacavir hypersensitivity (Martin et al 2004), autoimmune diseases (Pugliese et al 1992;Favatier et al 1997;Fraile et al 1998;Vargas-Alarcon et al 2002), lung cancer (Rusin et al 2004), and acute high altitude illness (Zhou et al 2005).…”

Section: Introductionmentioning

confidence: 99%

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Association of hsp70 polymorphisms with risk of noise-induced hearing loss in Chinese automobile workers

Yang¹,

Tan²,

Yang³

et al. 2006

Cell Stress Chaper

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Severe noise exposure can induce heat shock proteins (Hsps), and exposure to moderate noise has been reported to confer protection against noise-induced damage to hearing. Whether there is any association of genetic variation in both constitutive and inducible hsp70 genes with noise-induced hearing loss (NIHL) is presently unknown. Using polymerase chain reaction-restriction fragment length polymorphism, we genotyped 3 polymorphisms (ϩ190A/ B, ϩ1267A/B, and ϩ2437A/B) in the hsp70-1 (rs1043618), hsp70-2 (rs1061581), and hsp70-hom (rs2227956) genes, respectively, and investigated the associations of these polymorphisms with risk of developing NIHL in 194 automobile workers working in a similar noise environment as evaluated by audiological assessment. Multivariate logistic regression models were used to assess the associations with the risk genotypes, and Whap software was used to analyze their haplotypes. Our results showed that there was no statistically significant difference in the genotype and allele distributions of hsp70-1, hsp70-2, and hsp70-hom between the NIHL group and the normal group (P Ͼ 0.05) with and without adjustment for age, sex, smoking, history of explosive noise exposure, and cumulative noise exposure. However, haplotype analysis revealed that the Hap5 (ie, haplotype ϩ190A/ϩ1267B/ϩ2437A) and Hap6 (ie, haplotype ϩ190A/ϩ1267B/ϩ2437B) were significantly more frequent in the NIHL group than in the normal group (20/9, P ϭ 0.022, and 7/0, P ϭ 0.005, respectively). Compared with Hap1 (ie, ϩ190A/ϩ1267A/ϩ2437A), Hap5 was associated with a nearly 3-fold increased risk of NIHL (adjusted odds ratio, 2.67; 95% confidence interval, 1.13-6.27). Seven of the NIHL patients had Hap6, but none of the controls had this haplotype. Our results suggest that some haplotypes of the hsp70 genes may be associated with a higher susceptibility to NIHL.

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Section: Discussionmentioning

confidence: 48%

Section: Introductionmentioning

confidence: 99%

Association of hsp70 polymorphisms with risk of noise-induced hearing loss in Chinese automobile workers

Yang¹,

Tan²,

Yang³

et al. 2006

Cell Stress Chaper

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“…Furthermore, Hsp70 protein and its antibody have been identified as being involved in the pathogenesis of hypertension, atherosclerosis, coronary heart disease, acute heat-induced illness and heat stroke (Gromadzka et al, 2001;Wu et al, 2001;Pockley et al, 2003;Jin et al, 2004). Hsp70.1 and Hsp70.2 are polymorphic, potentially accounting for variation in their functions and susceptibility to stress tolerance (Ross et al, 2003;Wu et al, 2004;Zhou et al, 2005). Single nucleotide polymorphisms (SNPs) in the coding region of Hsp70 genes could affect peptide-binding kinetics or affinity of the Hsp70 proteins and ATPase activity, while nucleotide changes in the flanking regions (promoter and 5 0 , 3 0 -untranslated region (UTR)) might affect inducibility, degree of expression or stability of Hsp70 mRNA.…”

Section: Hsp70 Genotype and Heat Stressmentioning

confidence: 99%

Metabolic and hormonal acclimation to heat stress in domesticated ruminants

Bernabucci

Lacetera

Baumgard

et al. 2010

Animal

711

492

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Environmentally induced periods of heat stress decrease productivity with devastating economic consequences to global animal agriculture. Heat stress can be defined as a physiological condition when the core body temperature of a given species exceeds its range specified for normal activity, which results from a total heat load (internal production and environment) exceeding the capacity for heat dissipation and this prompts physiological and behavioral responses to reduce the strain. The ability of ruminants to regulate body temperature is species-and breed-dependent. Dairy breeds are typically more sensitive to heat stress than meat breeds, and higher-producing animals are more susceptible to heat stress because they generate more metabolic heat. During heat stress, ruminants, like other homeothermic animals, increase avenues of heat loss and reduce heat production in an attempt to maintain euthermia. The immediate responses to heat load are increased respiration rates, decreased feed intake and increased water intake. Acclimatization is a process by which animals adapt to environmental conditions and engage behavioral, hormonal and metabolic changes that are characteristics of either acclimatory homeostasis or homeorhetic mechanisms used by the animals to survive in a new 'physiological state'. For example, alterations in the hormonal profile are mainly characterized by a decline and increase in anabolic and catabolic hormones, respectively. The response to heat load and the heat-induced change in homeorhetic modifiers alters post-absorptive energy, lipid and protein metabolism, impairs liver function, causes oxidative stress, jeopardizes the immune response and decreases reproductive performance. These physiological modifications alter nutrient partitioning and may prevent heat-stressed lactating cows from recruiting glucose-sparing mechanisms (despite the reduced nutrient intake). This might explain, in large part, why decreased feed intake only accounts for a minor portion of the reduced milk yield from environmentally induced hyperthermic cows. How these metabolic changes are initiated and regulated is not known. It also remains unclear how these changes differ between short-term v. long-term heat acclimation to impact animal productivity and well-being. A better understanding of the adaptations enlisted by ruminants during heat stress is necessary to enhance the likelihood of developing strategies to simultaneously improve heat tolerance and increase productivity.Keywords: ruminants, heat stress, metabolism, acclimation, adaptation ImplicationsHeat stress is a significant financial burden to animal agriculture in most areas of the world. Acclimation to heat stress imposes behavioral, physiological and metabolic adjustments to reduce the strain and enhances the likelihood of surviving the stress, and it also frequently reduces ruminant performance and compromises health. Improving our knowledge of physiological and metabolic mechanisms of acclimation may contribute to the development and adoption of proce...

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“…The gene is polymorphic, potentially accounting for variation in its functions and susceptibility to stress tolerance (Zhou et al 2005). An adenine (A) to guanine (G) polymorphism at HspA1B +1267 has been described; however, the polymorphism does not lead to any amino acid change in the Hsp70 protein.…”

Section: Introductionmentioning

confidence: 99%

Interaction of serum 70-kDa heat shock protein levels and HspA1B (+1267) gene polymorphism with disease severity in patients with chronic heart failure

Gombos

Förhécz

Pozsonyi

et al. 2008

Cell Stress and Chaperones

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Background Circulating heat shock protein 70 (Hsp70) is present in the circulation of healthy individuals and in patients with various disorders, including chronic heart failure (CHF). However, the source and routes of release of Hsp70 is only partially characterised in clinical samples. Aims The purpose of this study was to study the clinical and biological correlates of Hsp70 in a CHF population and, for the first time, to investigate the association of HspA1B (also known as Hsp70-2) +1267 alleles with serum Hsp70 levels. Methods A total of 167 patients (123 men, 44 women) with <45% left ventricular ejection fraction (LVEF) were enrolled; serum Hsp70 level was determined by enzymelinked immunosorbent assay and HspA1B +1267 polymorphism by polymerase chain reaction-restriction fragment length polymorphism.

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Association of hsp70-2 and hsp-hom gene polymorphisms with risk of acute high-altitude illness in a Chinese population

Cited by 48 publications

References 56 publications

Association of hsp70 polymorphisms with risk of noise-induced hearing loss in Chinese automobile workers

Association of hsp70 polymorphisms with risk of noise-induced hearing loss in Chinese automobile workers

Metabolic and hormonal acclimation to heat stress in domesticated ruminants

Interaction of serum 70-kDa heat shock protein levels and HspA1B (+1267) gene polymorphism with disease severity in patients with chronic heart failure

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