Hsa_circ_NOTCH3 regulates ZNF146 through sponge adsorption of miR-875-5p to promote tumorigenesis of hepatocellular carcinoma

Bao, Lei; Wang, Min; Fan, Qiqi

doi:10.21037/jgo-21-567

Cited by 9 publications

(6 citation statements)

References 28 publications

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“…Moreover, the downregulation of ZNF146 reversed the malignant phenotype of overexpressing ZBED5-AS1 on cell proliferation, invasion, and migration. In fact, similar to our discovery, ZNF146 upregulation has been well-documented in hepatocellular carcinoma and colorectal cancer [11,28,29]. In addition, ZNF146 was observed to be the downstream target of the LncRNA KCNQ1OT1, and it promoted the development of colorectal cancer [29].…”

Section: Discussionsupporting

confidence: 86%

Long Noncoding RNA ZBED5-AS1 Facilitates Tumor Progression and Metastasis in Lung Adenocarcinoma via ZNF146/ATR/Chk1 Axis

Jiang,

Huang,

Ling

et al. 2023

IJMS

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Long noncoding RNAs (lncRNAs) have been implicated in tumorigenesis, including lung adenocarcinoma (LUAD). However, the functional and regulatory mechanisms of lncRNAs in LUAD remain poorly understood. In this study, we investigated the role of lncRNA ZBED5-AS1 in LUAD. We found that ZBED5-AS1 was upregulated in LUAD specimens and overexpressed in LUAD cell lines. ZBED5-AS1 promoted LUAD cell proliferation, migration, and invasion in vitro and promoted LUAD cell growth in vivo. ZBED5-AS1 promoted ZNF146 expression, activating the ATR/Chk1 pathway and leading to LUAD progression. We observed that exosomes from LUAD cells have a higher expression of ZBED5-AS1 compared with exosomes from the normal cell line BEAS-2B. Coculture experiments with exosomes showed that ZBED5-AS1 expression was downregulated after coculture with Si-ZBED5-AS1 exosomes, and coculture with exosomes with low ZBED5-AS1 expression inhibited proliferation and invasion of LUAD cells. Our results indicate that ZBED5-AS1 functions as an oncogenic factor in LUAD cells by targeting the ZNF146/ATR/Chk1 axis.

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Section: Discussionsupporting

confidence: 86%

Long Noncoding RNA ZBED5-AS1 Facilitates Tumor Progression and Metastasis in Lung Adenocarcinoma via ZNF146/ATR/Chk1 Axis

Jiang,

Huang,

Ling

et al. 2023

IJMS

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“…circRNAs act as key regulators in various diseases. Bao et al discovered that circ_NOTCH3 promoted tumorigenesis 13 Computational and Mathematical Methods in Medicine and invasion of hepatocellular carcinoma cells by sponging miR-875-5p and regulating ZNF146 level [17]. Zhang et al stated that circ_0003204 facilitated oxidative stress and endothelial cell apoptosis in atherosclerosis by miR-330-5p/Nod2 axis [18].…”

Section: Discussionmentioning

confidence: 99%

circ_0041795 Induces YAP1 Upregulation to Accelerate the Progression of Diabetic Retinopathy through Binding to miR-589-5p

Sun

Liú

Wei

2022

Computational and Mathematical Methods in Medicine

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Background. Circular RNAs (circRNAs) are involved in the pathogenesis of many diseases, and circ_0041795 was shown to promote the progression of diabetic retinopathy (DR). The aim of this study was to explore the molecular mechanism of circ_0041795 in DR. Methods. Human retinal pigment epithelial cells ARPE-19 were treated with high glucose (HG). circ_0041795, miR-589-5p, and Yes-associated protein 1 (YAP1) levels were measured by reverse transcription-quantitative polymerase chain reaction assay. Biological behaviors were examined by Cell Counting Kit-8 assay for cell viability, EdU assay for cell proliferation, flow cytometry for cell apoptosis, and enzyme-linked immunosorbent assay for cell inflammation. Oxidative stress was assessed via the commercial kits. Western blot was performed for analysis of protein expression. The molecular binding was assessed via dual-luciferase reporter assay and pull-down assay. Results. HG-induced inhibiting effects on cell viability and proliferation but promoting effects on cell apoptosis, inflammation, and oxidative stress were ameliorated by silence of circ_0041795. circ_0041795 was identified to act as a miR-589-5p sponge. The regulation of circ_0041795 in HG-induced cell injury was achieved by inhibiting miR-589-5p. miR-589-5p targeted YAP1 and relieved HG-induced cell dysfunction via downregulating YAP1. circ_0041795 sponged miR-589-5p to regulate YAP1 level and activated the NF-κB pathway through the miR-589-5p/YAP1 axis. Conclusion. All these results elucidated that circ_0041795 facilitated the development of DR by inducing miR-589-5p-mediated YAP1 upregulation.

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“…ZNF146 and ZNF580 are both members of the C2H2 family of Zinc finger proteins. ZNF146 was reported to be targeting to distinct sites within LINE-1 sequences at thousands of locations in the genome and to promote tumorigenesis of HCC, gastric cancer, and colorectal cancer ( Ma et al, 2020 ; Bao et al, 2021 ; Zhu et al, 2021 ; Creamer et al, 2022 ). ZNF580 was reported to regulate the gene expression of VEGF-A, IL-8, MMP2, and SMAD2 and is involved in angiogenesis, endothelial inflammation, and cell migration and proliferation ( Sun et al, 2010 ; Stenzel et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

TMEM147 is a novel biomarker for diagnosis and prognosis of hepatocellular carcinoma

et al. 2023

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Hepatocellular carcinoma (HCC) is the most common type of liver malignancy with high incidence and poor prognosis. Transmembrane protein 147 (TMEM147) has been implicated in the development of colon cancer. However, the role of TMEM147 in HCC remains unclear. In this study, data of 371 HCC tissues, 50 adjacent nontumor tissues, and 110 normal liver tissues were retrieved from the TCGA and GTEx databases. TMEM147 expression was found to be increased in HCC tissues. High expression of TMEM147 was related to poor prognosis, and TMEM147 was confirmed to be an independent prognostic factor for HCC patients. A receiver operating characteristics (ROC) analysis was performed and showed that the diagnostic efficacy of TMEM147 was significantly higher than that of AFP (0.908 versus 0.746, p < 0.001). Furthermore, TMEM147 promoted tumor immune infiltration, and macrophages were the immune cells that predominantly expressed TMEM147 in HCC. Further analysis revealed that TMEM147 mainly impacted the ribosome pathway, and CTCF, MLLT1, TGIF2, ZNF146, and ZNF580 were predicted to be the upstream transcription factors for TMEM147 in HCC. These results suggest that TMEM147 serves as a promising biomarker for diagnosis and prognosis and may potentially become a therapeutic target for HCC.

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Hsa_circ_NOTCH3 regulates ZNF146 through sponge adsorption of miR-875-5p to promote tumorigenesis of hepatocellular carcinoma

Cited by 9 publications

References 28 publications

Long Noncoding RNA ZBED5-AS1 Facilitates Tumor Progression and Metastasis in Lung Adenocarcinoma via ZNF146/ATR/Chk1 Axis

Long Noncoding RNA ZBED5-AS1 Facilitates Tumor Progression and Metastasis in Lung Adenocarcinoma via ZNF146/ATR/Chk1 Axis

circ_0041795 Induces YAP1 Upregulation to Accelerate the Progression of Diabetic Retinopathy through Binding to miR-589-5p

TMEM147 is a novel biomarker for diagnosis and prognosis of hepatocellular carcinoma

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