hsa_circ_0007841: A Novel Potential Biomarker and Drug Resistance for Multiple Myeloma

Abstract

Purpose: Circular RNA (circRNA) is a key regulatory factor in the development and progression of human tumors. However, the working mechanism and clinical significance of most circRNAs remain unknown in human cancers, including multiple myeloma (MM).Patients and Methods: This study employs high-throughput circRNA microarray with bioinformatics to identify differentially expressed circRNAs in patients with MM. The hsa_circ_0007841 expressions were observed in the MM tissues of 86 patients. Drug-resistant cell lines and pathological features were also detected. In addition, the relationship between hsa_circ_0007841 expressions in the MM tissues and the pathological features of patients with MM were evaluated and role of hsa_circ_0007841 as a potential biomarker and therapeutic target was assessed.Results: The results show that in the MM cell lines and drug-resistant cell lines, hsa_circ_0007841 expression was significantly upregulated, which was closely associated with disease prognosis. Specifically, hsa_circ_0007841 upregulation was correlated with chromosomal aberrations such as gain 1q21, t (4:14) and mutations in ATR and IRF4 genes. This finding was corroborated in large samples. Finally, bioinformatics analysis showed that eight differentially expressed miRNAs and 10 candidate mRNAs interacted with hsa_circ_0007841, shedding some new light on the basic functional research.Conclusion: This study may be the first to report that hsa_circ_0007841 is significantly upregulated in MM. It also suggests that hsa_circ_0007841 may be a novel biomarker for MM and its involvement in the progression of MM.

Circ_0007841 promotes the progression of multiple myeloma through targeting miR-338-3p/BRD4 signaling cascade

“…Further studies suggested that circ_0007841 promoted the proliferation, cell cycle, metastasis and inhibited the apoptosis of MM cells. These findings demonstrated that circ_0007841 might be an important biomarker for MM patients, which was in agreement with the former article [28]. However, the regulatory mechanism by which circ_0007841 promoted the progression of MM was unclear.…”

<p>Biological Roles and Mechanisms of Circular RNA in Human Cancers</p>

“…11 CircRNAs may also play a key role in the development of drug resistance. Recently, multiple studies have highlighted the key roles of ncRNAs in chemoresistance of cancer, such as HCC, 142,249 lung cancer, 250,251 gastric cancer, 252,253 breast cancer, 254,255 multiple myeloma, 256 acute myeloid leukemia, 234 prostate cancer, 257 bladder cancer, 258 among others. The up-to-date information regarding the role of circRNAs in the resistance of tumors to chemotherapy has been recently summarized with multiple mechanisms, such as modulating various regulatory pathways and processes including the ceRNA regulatory network axis, EMT process, regulation of ABC transporters, apoptosis, autophagy, and CSCs, among others although many physiological processes and biological signaling pathways through which circRNAs are involved in drug resistance still remained unknown.…”

Functions and mechanisms of circular RNAs in cancer radiotherapy and chemotherapy resistance

“…Hsa_circ_0007841 is upregulated in bortezomib-resistant multiple myeloma (MM) cells and significantly correlated with the poor prognosis of MM patients [150]. CiRS-7 is downregulated in melanoma and negatively correlates with melanoma progression by interacting with the RBP IGF2BP3.…”