Hsa_circ_0004287 inhibits macrophage-mediated inflammation in an N6-methyladenosine–dependent manner in atopic dermatitis and psoriasis

Yang, Lan; Fu, Jinrong; Han, Xiao; Zhang, Caiyan; Li, Xia; Zhu, Ronghui; Huang, Saihua; Xiao, Wenfeng; Yu, Hongmiao; Gao, Yajing; Liang, Qiuyan; Li, Wei; Zhou, Yufeng

doi:10.1016/j.jaci.2021.11.024

Cited by 56 publications

(44 citation statements)

References 37 publications

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“… 15 Here, we found that macrophages were the main group of immune cells in IMQ-induced psoriasis mice, which may explain the reason that regulating macrophages can alleviate IMQ-induced psoriasis symptoms. 37 The number of macrophages was found to increase in the dermis of human psoriasis lesions, 38 but it is worth noting that the scRNA-seq results showed that macrophages accounted for a small proportion in human psoriasis skin. 15 DEG analysis showed that Fcgr4 and Saa3 involved in inflammatory response were widely expressed in macrophages of psoriasis mice.…”

Section: Discussionmentioning

confidence: 99%

“…15 Here, we found that macrophages were the main group of immune cells in IMQ-induced psoriasis mice, which may explain the reason that regulating macrophages can alleviate IMQ-induced psoriasis symptoms. 37 The number of macrophages was found to increase in the dermis of human psoriasis lesions, 38 but it is worth noting that the scRNA-seq results showed that https://doi.org/10.2147/JIR.S379349…”

Section: Discussionmentioning

confidence: 99%

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Single-Cell RNA Sequencing Reveals the Immune Cell Profiling in IMQ Induced Psoriasis-Like Model

Jin¹,

Wang²,

Qie³

et al. 2022

JIR

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Purpose Psoriasis is a chronic systemic inflammatory skin disease with a high recurrence rate. The immune response plays an important role in psoriasis. However, the subsets of immune cells involved in inflammation in psoriatic mice have not been fully studied. This study showed the immune environment characteristics of psoriasis in mice. Methods We used single-cell RNA sequencing (10× Genomics) as an unbiased analytical strategy to investigate the heterogeneity of skin immune cells in imiquimod-induced psoriasis mice systematically. Results We identified 10 major clusters and their marker genes among 14,439 cells. The proportions of macrophages, NK/T cells, conventional dendritic cells (cDCs) and plasmacytoid dendritic cells (pDCs) were increased in psoriatic mice. Macrophages were the largest group and were further divided into 7 subgroups, and all macrophage clusters were increased in psoriatic mice. Differentially expressed genes in control versus psoriatic mice skin lesions showed that Fcgr4, Saa3 and Acp5 in macrophages, Acp5, Fcgr4 and Ms4a6d in NK/T cells, Saa3 in cDCs, and Ifitm1 in pDCs were upregulated in psoriasis mice. Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathway enrichment analysis emphasized the role of oxidative phosphorylation signals and antigen processing and presentation signals in murine psoriasis-like models. Conclusion Our study reveals the immune environment characteristics of the commonly used IMQ induced psoriasis-like models and provides a systematic insight into the immune response of mice with psoriasis, which is conducive to comparing the similarities and differences between the mouse model and human psoriasis.

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Section: Discussionmentioning

confidence: 99%

“…15 Here, we found that macrophages were the main group of immune cells in IMQ-induced psoriasis mice, which may explain the reason that regulating macrophages can alleviate IMQ-induced psoriasis symptoms. 37 The number of macrophages was found to increase in the dermis of human psoriasis lesions, 38 but it is worth noting that the scRNA-seq results showed that https://doi.org/10.2147/JIR.S379349…”

Section: Discussionmentioning

confidence: 99%

Single-Cell RNA Sequencing Reveals the Immune Cell Profiling in IMQ Induced Psoriasis-Like Model

Jin¹,

Wang²,

Qie³

et al. 2022

JIR

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“…Hsa_circ_0004287, one of circular RNA (circRNA), inhibited M1 macrophage activation in an N 6-methyladenosine-dependent manner in atopic dermatitis and psoriasis ( 112 ).…”

Section: Macrophagesmentioning

confidence: 99%

Dendritic Cells and Macrophages in the Pathogenesis of Psoriasis

Kamata

Tada

2022

Front. Immunol.

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Psoriasis is a chronic inflammatory skin disease characterized by scaly indurated erythema. This disease impairs patients’ quality of life enormously. Pathological findings demonstrate proliferation and abnormal differentiation of keratinocytes and massive infiltration of inflammatory immune cells. The pathogenesis of psoriasis is complicated. Among immune cells, dendritic cells play a pivotal role in the development of psoriasis in both the initiation and the maintenance phases. In addition, it has been indicated that macrophages contribute to the pathogenesis of psoriasis especially in the initiation phase, although studies on macrophages are limited. In this article, we review the roles of dendritic cells and macrophages in the pathogenesis of psoriasis.

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“…Early studies indicated that HDM (45), DNCB (46), ovalbumin (47), and calcipotriol (48) cause exacerbation of AD. DNCB is often used to induce AD in mouse models of AD, as the results are highly reproducible and repeatable (49)(50)(51).…”

Section: Discussionmentioning

confidence: 99%

Inhibitory effects of isoliquiritin on an atopic dermatitis model through the CD177/JAK2/STAT pathway in vitro and in vivo

Wu¹,

Mo²,

Lin³

et al. 2022

Ann Transl Med

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Background: Atopic dermatitis (AD) is a complex inflammatory skin condition characterized by the proliferation and activation of immune cells in skin. Isoliquiritin (ISO) is an active component purified from Glycyrrhiza glabra. This study aimed to test the therapeutic potential of ISO for AD and verify its potential molecular mechanism.Methods: This study investigated the potential effects and possible underlying mechanisms of ISO against AD in vitro (HMC1.1 cells stimulated by phorbol-12-myristate-13-acetate and calcium ionophore A23187) and in vivo (AD-like mouse model induced by 1-chloro-2,4-dinitrochlorobenzene).Results: ISO dose-dependently suppressed the viability of HMC1.1 cells. ISO inhibited the secretion of the proinflammatory factors IL-6 and IL-8 and induced the apoptosis of HMC1.1 cells. ISO suppressed the phosphorylation of CD177, JAK2, STAT1, STAT3, and STAT5, and upregulated the protein expression of BAX and cleaved caspase-3 in vitro. ISO administration markedly diminished the infiltration of immune cells (mast cells, eosinophils) in cutaneous lesions. Simultaneously, ISO treatment alleviated the formation of skin lesions and affected other AD symptoms (thickness of the epidermis and dermis, ear edema, lymph node weight, spleen index, dermatitis score) but increased the thymus index in vivo, and downregulated expression of IL-4, IL-6, IgE, and thymic stromal lymphopoietin (TSLP).Conclusions: Collectively, our findings showed that ISO administration decreased skin lesion formation by inhibiting inflammation and enhancing immunomodulation through the CD177/JAK2/STAT signaling pathway.

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Hsa_circ_0004287 inhibits macrophage-mediated inflammation in an N6-methyladenosine–dependent manner in atopic dermatitis and psoriasis

Cited by 56 publications

References 37 publications

Single-Cell RNA Sequencing Reveals the Immune Cell Profiling in IMQ Induced Psoriasis-Like Model

Single-Cell RNA Sequencing Reveals the Immune Cell Profiling in IMQ Induced Psoriasis-Like Model

Dendritic Cells and Macrophages in the Pathogenesis of Psoriasis

Inhibitory effects of isoliquiritin on an atopic dermatitis model through the CD177/JAK2/STAT pathway in vitro and in vivo

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