HPV prevalence, E6 sequence variation and physical state of HPV16 isolates from patients with cervical cancer in Sichuan, China

Ai-dong, Qiu; Enqi, Wu; Yu, Xianghui; Jiang, Chunlai; Jin, Yinghua; Wu, Yongge; Chen, Yue; Chen, Yan; Shan, Yaming; Zhang, Guonan; Fan, Ying; Xiao, Zhengguo; Kong, Wei

doi:10.1016/j.ygyno.2006.07.016

Cited by 25 publications

(29 citation statements)

References 44 publications

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“…Our result does not correlate the previous studies performed by other countries like Norway (92%) 18 , Australia (90%) 19 and China (75-83%) 20 . Their results have shown the higher HPV prevalence because their study included detection of all high risk HPV Genotypes.…”

Section: Resultscontrasting

confidence: 99%

Prevalence of High Risk Human Papillomavirus (type-16 and 18) in High-Grade Cervical Intraepithelial Neoplasia (CIN) and Cervical Cancer in a Tertiary Hospital of Bangladesh

Shahida

Ansary

Begum

et al. 2018

J. Bangladesh Coll. Phys.

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Section: Resultscontrasting

confidence: 99%

Prevalence of High Risk Human Papillomavirus (type-16 and 18) in High-Grade Cervical Intraepithelial Neoplasia (CIN) and Cervical Cancer in a Tertiary Hospital of Bangladesh

Shahida

Ansary

Begum

et al. 2018

J. Bangladesh Coll. Phys.

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“…In Table 3, L83V mutations in northeast China accounted for 5.77%, close to those in central China and southern China, in contrast to that in southwest China (27.61% in Sichuan), 32.56% in Japan, and 84.38% in Russia (Moscow) (5,6,8,9,19,47,52). G94A was also reported in southwest China and Mongolia (8,35). Sequence variation at E7 displays geographic dependence (14,36).…”

Section: Discussionsupporting

confidence: 54%

“…The Asian lineage was reported in southwest China (31.0% in Sichuan) and southern China (50.6% in Hong Kong). The European prototype was reported in southwest China (23.0% in Sichuan), central China (15.52% in Hubei), and southern China (30.0% in Hong Kong) (5,6,35). No data on HPV 16 variants and sequence variations were reported in northern China and northeast China.…”

mentioning

confidence: 99%

Human Papillomavirus Type 16 Variant Analysis of E6, E7, and L1 Genes and Long Control Region in Identification of Cervical Carcinomas in Patients in Northeast China

et al. 2011

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Human papillomavirus type 16 (HPV 16) is the primary etiology of cervical cancer, which is the second most common type of cancer in women worldwide (29). HPV 16 variants, which vary by Յ2% from HPV 16 prototype nucleotide sequences, have been identified as the following six phylogenetic branches: European (E), Asian (As), Asian-American (AA), African-1 (Af-1), African-2 (Af-2), and northern American (NA) variants (18,52). Several researchers had reported correlations between specific HPV 16 variants and persistent viral infection, followed by the development of malignant lesions (3,4,16,37,43,49,50). Non-European variants were found to be associated with an excess risk of cervical cancer (37). These variants had been found to show different geographic distributions, while some sequence variations had oncogenic potentials. In HPV 16 variants, the L83V mutation in E6 in the Swedish and Italian populations and D25E in E6 in the Japanese population were reported to be associated with the

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“…The HPV 58 genome in 29 (78.4 %) out of 37 specimens was in pure integrated form. The proportion of pure integrated form detected in this study is much higher than in previous studies of both HPV 58 and HPV 16 (Arias-Pulido et al, 2006; Chan et al, 2007;Ho et al, 2006;Qiu et al, 2007). The possible reason for this is that the HPV 58 in many specimens included here exists at a much lower viral load and was only detectable by nested PCR methods.…”

Section: Discussioncontrasting

confidence: 70%

Profile of physical status and gene variation of human papillomavirus 58 genome in cervical cancer

Enqi

Xiao

et al. 2009

Journal of General Virology

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Epidemiological studies have shown that human papillomavirus 58 (HPV 58) is found at a relatively high frequency in east Asia and some regions of Central and South America. To investigate the physical status of HPV 58 and analyse sequence variations of HPV 58 in cervical cancer patients, the HPV 58 genome in 37 HPV 58-positive cervical cancer specimens collected from China were investigated by a mapping analysis based on nested PCR and nucleotide sequencing. A pure integrated genome was found in 78.4 % (29/37) of specimens, which is much higher than that found in previous studies. Multiple disruptions were first found among the integrated HPV 58 genomes in 51.7 % (15/29) of specimens. Among the 7824 bp of the HPV 58 genome, 119 (1.52 %) nucleotide positions were found to be variable, and 45 of them lead to amino acid changes. Phylogenetic analyses, based on partial L1 sequences of 14 variants isolated in previous studies and this study, show that two main groups were observed in HPV 58 variants, the prototype or prototype-like group and the non-prototype-like group.

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HPV prevalence, E6 sequence variation and physical state of HPV16 isolates from patients with cervical cancer in Sichuan, China

Cited by 25 publications

References 44 publications

Prevalence of High Risk Human Papillomavirus (type-16 and 18) in High-Grade Cervical Intraepithelial Neoplasia (CIN) and Cervical Cancer in a Tertiary Hospital of Bangladesh

Prevalence of High Risk Human Papillomavirus (type-16 and 18) in High-Grade Cervical Intraepithelial Neoplasia (CIN) and Cervical Cancer in a Tertiary Hospital of Bangladesh

Human Papillomavirus Type 16 Variant Analysis of E6, E7, and L1 Genes and Long Control Region in Identification of Cervical Carcinomas in Patients in Northeast China

Profile of physical status and gene variation of human papillomavirus 58 genome in cervical cancer

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