HPV Infections in Heterosexual Couples: Mechanisms and Covariates of Virus Transmission

Kero, Katja; Rautava, Jaana

doi:10.1159/000494710

Cited by 13 publications

(9 citation statements)

References 45 publications

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“…The most common HPV types in concordance were HPV16, HPV18 and HPV6. 5 , 6 , 19 , 23–34 In our study, HPV concordance rate between sexual partners was 61.19%, which was consistent with previous data. The most common types in concordance were HPV16 (16.67%,23/138), HPV52 (10.87%,15/138), HPV53 (10.14%,14/138), HPV6 (7.97%,11/138), HPV58 (7.25%,10/138).…”

Section: Discussionsupporting

confidence: 93%

“…3 For the past few years, a lot of research reported that frequent HPV infection existed between heterosexual partners during sexual behaviors including genital intercourse, oral sex, anal sex and so on. [4][5][6][7][8] Previous studies suggested that HPV prevalence in males was 2.9-65.5% in general population. 3,[9][10][11][12][13] HPV infection in males (including genital sites, semen and so on) is responsible for repeated and persistent HPV infection in female sexual partners, which can cause cervical lesions.…”

Section: Introductionmentioning

confidence: 99%

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Genital HPV Prevalence, Follow-Up and Persistence in Males and HPV Concordance Between Heterosexual Couples in Wenzhou, China

Hu¹,

Ji²,

Li³

et al. 2022

IDR

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Purpose This study aimed to investigate male HPV infection, re-examination rate, clearance rate and relevant influencing factors as well as HPV infection between heterosexual partners in Wenzhou, China. Methods The study enrolled 2359 men who accepted ≥1 HPV detection in the First Affiliated Hospital of Wenzhou Medical University between June 2014 and June 2020. An outpatient follow-up was carried out for collecting HPV re-test results among males who were tested HPV positive. In addition, we collected female sexual partners’ HPV infection state through outpatient information system or telephone call. For males who had not re-tested HPV more than half a year after the first HPV positive result, a telephone follow-up would be provided. Results Male HPV prevalence was 39.39% (928/2359) at baseline, of which the median age was 38.00 years. The percentage of co-infection and HR HPV infection was 35.24% (327/928) and 61.08% (874/1431). Genotype-specific concordance of HPV infection among heterosexual partners was 61.19% (123/201). The most common types were HPV6, HPV52, HPV16, HPV53, HPV11, HPV43 and HPV58. Percentage of males finishing HPV re-examination was low (40.09%). Infection with HR HPV, discomfort or HPV-related diseases and sexual partners with HPV infection were possible motivator for male HPV re-test. The medium time to male HPV clearance was 300.000 (95% CI=274.845–325.155) days. Infection with HR HPV, sexual partners with HPV infection and growth of age might prolong HPV persistence time included. Conclusion Males are susceptible population for genital HPV infection as well as females. Whereas, males are generally less aware of HPV and its influence on their couples. The study showed that male HPV testing as well as the role of males in the diagnosis and treatment of HPV-associated cervical diseases for females should be popularized and co-treatment of couples was necessary.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Genital HPV Prevalence, Follow-Up and Persistence in Males and HPV Concordance Between Heterosexual Couples in Wenzhou, China

Hu¹,

Ji²,

Li³

et al. 2022

IDR

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“…-the correct information of the family members regarding the presence of the infection and the mode of transmission Kero, & Rautava, 2019);…”

Section: Discussionmentioning

confidence: 99%

Functional Implications of Oral Papillomatosis

Andrei

Buşu

Bobilca

et al. 2022

BRAIN

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The papillomatous lesion has a number of implications that destabilize the normal functioning of the stomatognathic system, but also it has psychological implications. A patient with a papilloma located in an area of maximum visibility tends to be less exposed in public, to reduce socialization, to feel embarrassed. Oral papilloma affects the masticatory function, phonation, but also aesthetics. Understanding how local immunity works in patients diagnosed with oral papilloma is essential. Local immunity influences the evolution of the papillomatous oral lesion. Toll-like receptors are extremely important in the immune process of oral papilloma. Toll-like receptors can be used as indicators of lesion progression. A reduced expression of these receptors in the focus of the lesion is suggestive of pathological progress. It is also emphasized that in the oral cavity we find a well-represented local immune system which cells have an immune role and whose expression influences the evolution of the disease. The most incriminating factor in the occurrence of oral papilloma is HPV infection. The persistent inflammatory process produced by the HPV virus stimulates the development of oral, pharyngeal, laryngeal neoplasms. The HPV virus acts as a direct inducer in the process of transforming the benign lesion into a malignant lesion. Macrophages play an important role in the malignancy potential induced by the HPV virus. Macrophages are activated by increasing the metabolic rate and fighting tumor cells.

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“…16 However, other PCR-based techniques for HPV detection can vary in their sensitivity. Miller et al, 17 report the following sensitivity for the different techniques for detection of HPV DNA: high sensitivity (PCR, 37.1%), moderate sensitivity (Southern blot, 25.2%), 18,19 and low-sensitivity (in situ hybridization or immuno-histochemistry).…”

Section: A H E a D O F P R I N T ]mentioning

confidence: 99%

Frequency of high-risk genotypes of human papilloma virus in oral lesions

et al. 2020

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Some genotypes of the human papilloma virus (HPV) in the oral cavity cause genetic instability that may lead to cancer. Clinical and histological diagnoses are key tools; however, molecular techniques allow predicting, detecting and monitoring the disease. Objective: To identify the frequency of four high-risk HPV genotypes and their association with lesions in the oral cavity. Materials and Methods: Descriptive cross-sectional study with a sample of 48 patients diagnosed with hyperplastic lesions and others currently classified as potentially malignant disorders (PMDs) of the oral cavity, who underwent biopsies, histopathological analysis, and HPV16, 18, 31, and 45 detection and genotyping by polymerase chain reaction (PCR). Results: Epithelial hyperplasia was the most frequent lesion found in 45.8% (n=22) of patients. Nicotine palatinus and leukoplakia were found in 8.3% and 6.2%, respectively; oral cancer in 6.2%. The total frequency of HPV was 12.5% (6/48). Oral papilloma was found in 6.1% (3/48), and nicotine palatinus and oral cancer in 2.0% each (1/48). HPV16, HPV31, and HPV45 were detected, while HPV18 was not observed. HPV16 was the most frequent genotype found (4 out of 6 patients), while HPV31 and HPV45 were found in one patient each. Only one genotype per lesion was found. The presence of HPV was associated with lesions (χ 2 =11.810; p=0.0375). No significant association with age and gender was found. Conclusion: High-risk HPV continues to be present in oral lesions. The HPV16 viral genotype was the most frequent in the studied lesions.

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HPV Infections in Heterosexual Couples: Mechanisms and Covariates of Virus Transmission

Cited by 13 publications

References 45 publications

Genital HPV Prevalence, Follow-Up and Persistence in Males and HPV Concordance Between Heterosexual Couples in Wenzhou, China

Genital HPV Prevalence, Follow-Up and Persistence in Males and HPV Concordance Between Heterosexual Couples in Wenzhou, China

Functional Implications of Oral Papillomatosis

Frequency of high-risk genotypes of human papilloma virus in oral lesions

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