HPLC determination of free nitrogenous compounds of Centaurea solstitialis (Asteraceae), the cause of equine nigropallidal encephalomalacia

Moret, Sabrina; Populin, Tiziana; Purcaro, Giorgia; Cosens, Gladys

doi:10.1016/j.toxicon.2005.07.006

Cited by 18 publications

(7 citation statements)

References 17 publications

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“…Infestation of C. solstitialis has been reported to be approximately 8 million hectares in the western U.S. and Canada and is considered to be the most widespread in California , . One of the primary concerns regarding the insidious growth of C. solstitialis is toxicity to horses , . Ingestion of C. solstitialis by horses induces the neurodegenerative disease nigropallidal encephalomalacia, reportedly due to the sesquiterpene lactone repin, a natural product of C. solstitialis and Acroptilon repens (L.) DC.…”

Section: Introductionmentioning

confidence: 99%

In Situ Volatile Collection, Analysis, and Comparison of Three Centaurea Species and Their Relationship to Biocontrol with Herbivorous Insects

Beck

Smith

Merrill

2008

J. Agric. Food Chem.

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Centaurea solstitialis, commonly known as yellow starthistle, is an invasive plant listed as a noxious weed in the western areas of North America and is the target of classical biological control, which involves release of herbivores known to be specific to this plant. These insects often choose their host plant on the basis of the volatile organic compounds (VOCs) emitted. Accordingly, volatile analysis of host plants can provide insight into VOCs that may attract and/or repel the insect. To this end, solid-phase microextraction (SPME) and a customized collection bag were utilized to perform in situ volatile collection on intact and mechanically damaged leaves of Centaurea solstitialis, Centaurea cyanus, and Centaurea cineraria. Volatile identification was performed by GC-MS, and the VOC differences were determined. The plants C. solstitialis and C. cyanus have been reported to attract the weevil, Ceratapion basicorne, a candidate for biological control, whereas C. cineraria does not attract the weevil. Major VOCs unique to C. cineraria include the sesquiterpenes cyclosativene, alpha-ylangene, and trans-alpha-bergamotene. The compound trans-beta-farnesene was unique to C. solstitialis and C. cyanus.

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Section: Introductionmentioning

confidence: 99%

In Situ Volatile Collection, Analysis, and Comparison of Three Centaurea Species and Their Relationship to Biocontrol with Herbivorous Insects

Beck

Smith

Merrill

2008

J. Agric. Food Chem.

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“…33 and Moret et al. 29 isolated anti-oxidative peptides from fish skin gelatin and discovered that their major amino acid residues included glycine, proline, and tyrosine. Rajapakse et al.…”

Section: Resultsmentioning

confidence: 99%

“…The samples were derived with ο-phthaldialdehyde (OPA) (Sigma) and separately analyzed by reverse-phase HPLC according to Moret et al. 29 A Hitachi L-1700 HPLC system (Tokyo, Japan) was used with a Myghtysil RP-18 column (250 mm × 4.6 mm; Kanto, Tokyo, Japan). The mobile phases were phosphate buffer (pH 7.0; solvent A), acetonitrile (solvent B; Merck, Darmstadt, Germany), and deionized water (solvent C).…”

Section: Methodsmentioning

confidence: 99%

The bioactive composite film prepared from bacterial cellulose and modified by hydrolyzed gelatin peptide

Lin

Chen

et al. 2015

J Biomater Appl

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The hydrolyzed gelatin peptides, obtained from the hydrolysis of Tilapia nilotica skin gelatin with alcalase and pronase E, were fractionated using an ultrafiltration system into hydrolyzed gelatin peptides-a (10 kDa membrane), hydrolyzed gelatin peptides-b1, and hydrolyzed gelatin peptides-b2 (5 kDa membrane) fractions. The highest oxygen radical absorbance capacity was observed in hydrolyzed gelatin peptides-b2, which contained more nonpolar amino acids than the other hydrolyzed gelatin peptides. Hydrolyzed gelatin peptides-b2 at a concentration of 12.5 mg/ml exhibited the highest proliferation ability and increased the expression of Type I procollagen mRNA, which indicated an enhanced collagen synthesis. Hydrolyzed gelatin peptides protected Detroit 551 cells from 2,2'-azobis(2-amidinopropane) dihydrochloride-induced oxidative damage and increased cell viability. Hydroxylpropylmethyl cellulose-modified bacterial cellulose and dried fabricated biofilm were less eligible for Detroit 551 cell proliferation than bacterial cellulose. The release of hydrolyzed gelatin peptides in bacterial cellulose film was slower than that in hydroxylpropylmethyl cellulose-modified bacterial cellulose and dried fabricated biofilm; thus, bacterial cellulose film and hydroxylpropylmethyl cellulose-modified bacterial cellulose and dried fabricated biofilm are suitable candidates for applications in delayed release type and rapid release type biofilms, respectively.

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“…The toxin causing equine NPEM remains uncertain. Tyramine and the sesquiterpene lactone repin have both been proposed as causative agents 2,10 . The characteristics of the brain lesions in affected horses suggest that the toxin involved results in dopamine deficiency in the dopaminergic nigrostriatal pathway after an initial massive release of stored neurotransmitters into the corpus striatum 2,7 .…”

mentioning

confidence: 99%

“…Tyramine and the sesquiterpene lactone repin have both been proposed as causative agents. 2,10 The characteristics of the brain lesions in affected horses suggest that the toxin involved results in dopamine deficiency in the dopaminergic nigrostriatal pathway after an initial massive release of stored neurotransmitters into the corpus striatum. 2,7 The ability of repin to induce neurotoxicity in rodents, in which reduced levels of striatal extracellular dopamine and hippocampal glutathione were seen, coupled with its vastly higher concentration within R. repens appears to make it the more likely of the two to be the causative toxin.…”

mentioning

confidence: 99%

Nigropallidal encephalomalacia in horses grazing Rhaponticum repens (creeping knapweed)

Elliott

McCowan²

2012

Aust Veterinary J

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Nigropallidal encephalomalacia was diagnosed in two horses in northern Victoria that had a history of long-term pasture access to a dense growth of Rhaponticum repens. The region in which the affected horses lived had received well above average rainfall for several months preceding the poisoning. Affected horses had sudden onset of subcutaneous oedema of the head, impaired prehension and mastication, dullness, lethargy and repeated chewing-like jaw movements. Diagnosis was confirmed at necropsy, with characteristic malacic lesions in the substantia nigra and globus pallidus of the brain. This is the first documented case of nigropallidal encephalomalacia in Australian horses associated with R. repens.

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HPLC determination of free nitrogenous compounds of Centaurea solstitialis (Asteraceae), the cause of equine nigropallidal encephalomalacia

Cited by 18 publications

References 17 publications

In Situ Volatile Collection, Analysis, and Comparison of Three Centaurea Species and Their Relationship to Biocontrol with Herbivorous Insects

In Situ Volatile Collection, Analysis, and Comparison of Three Centaurea Species and Their Relationship to Biocontrol with Herbivorous Insects

The bioactive composite film prepared from bacterial cellulose and modified by hydrolyzed gelatin peptide

Nigropallidal encephalomalacia in horses grazing Rhaponticum repens (creeping knapweed)

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