HPLC determination and pharmacokinetics of thiabendazole and its major metabolite 5-OH thiabendazole in equine plasma

Ge, Hardee; Ma, Tshabalala; Jn, Moore; Rd, Gokhales

doi:10.1016/s0034-5288(18)30733-1

Cited by 4 publications

(2 citation statements)

References 8 publications

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“…20 To date, various conventional analytical techniques have been developed for the quantification of TBZ in real samples. These methods include high-performance liquid chromatography (HPLC), 21 HPLC-mass spectrometry, 22 electroanalytical methods, 23 and capillary electrophoresis. 24 Despite their utility, these methods have certain limitations, such as being expensive, time-consuming, involving complicated operational processes, and requiring labor-intensive efforts.…”

Section: Introductionmentioning

confidence: 99%

Preparation of surface molecularly‐imprinted magnetic kaolin for selective separation and determination of thiabendazole

Zengin

2024

J of Applied Polymer Sci

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In this study, a selective sorbent was fabricated by combining a surface molecularly‐imprinted polymer and magnetic kaolin for reliable quantification of thiabendazole (TBZ) coupled with spectrofluorimetry. Several surface characterization methods were conducted to confirm the synthesis of TBZ‐imprinted magnetic kaolin with a polymer thickness of ~48 nm. The molecularly‐imprinted magnetic kaolin (MIP@MKLN) showed high adsorption capacity (8.7 mg/g), remarkable selectivity with an imprinting factor of 3.71 and excellent regeneration ability for up to 10 uses without significant change of its initial adsorption capacity for TBZ. The proposed method had linear range from 5 to 500 μg/mL TBZ concentration with a correlation coefficient of 0.995 and the limit of detection was 1.4 μg/mL. MIP@MKLN was used for selective separation and quantification of TBZ in orange and lemon samples. There were high recovery values ranging from 96.4% to 100.2% with lower relative standard deviations (less than 5%) in the spiked samples under optimized conditions. Overall, the proposed method based on MIP@MKLN as an excellent sorbent could produce a feasible, convenient, and promising method for rapid, selective, and sensitive quantification of TBZ in real samples.

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Section: Introductionmentioning

confidence: 99%

Preparation of surface molecularly‐imprinted magnetic kaolin for selective separation and determination of thiabendazole

Zengin

2024

J of Applied Polymer Sci

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“…6 Together with its major metabolite, 5-hydroxythiabendazole, it has been monitored to trace drug residues by means of a fluorometric methodology. 7,8 By contrast with the extensive use of 1, the photobehavior of this compound remains relatively unknown. In fact, the studies on the photochemistry of 1 are limited to aqueous or methanolic solutions and to the effect of singlet oxygen.…”

Section: Introductionmentioning

confidence: 99%

The triplet excited state of the bioactive compound thiabendazole. Characterization and suitability as reporter for cyclodextrin complexation

Bartovský

Domingo

Jornet

et al. 2012

Chemical Physics Letters

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Determination of thiabendazole residues in meat by HPLC using ultraviolet and fluorometric detection

Bukanski¹,

Degroodt²,

Beernaert³

1991

Z Lebensm Unters Forch

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An HPLC method is described for the residue analysis of thiabendazole in meat. The recovery varies from 62 to 75%. Thiabendazole is extracted from the tissue using 3 mol HCl, eluted from the Extrelut-20 column with dichloromethane and then injected onto a C18 column. The optimum conditions for detection are described using ultraviolet and fluorescence spectroscopy. The sensitivity is such that thiabendazole can be determined at a level of 5 micrograms/kg meat. The absolute detection limit with fluorometry is 100 pg.

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HPLC determination and pharmacokinetics of thiabendazole and its major metabolite 5-OH thiabendazole in equine plasma

Cited by 4 publications

References 8 publications

Preparation of surface molecularly‐imprinted magnetic kaolin for selective separation and determination of thiabendazole

Preparation of surface molecularly‐imprinted magnetic kaolin for selective separation and determination of thiabendazole

The triplet excited state of the bioactive compound thiabendazole. Characterization and suitability as reporter for cyclodextrin complexation

Determination of thiabendazole residues in meat by HPLC using ultraviolet and fluorometric detection

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