How Visual Stimuli Activate Dopaminergic Neurons at Short Latency

Dommett, Eleanor J.; Coizet, Véronique; Blaha, Charles D.; Martindale, John; Lefebvre, Véronique; Walton, Natalie; Mayhew, John E. W.; Overton, Paul G.; Redgrave, Peter

doi:10.1126/science.1107026

Cited by 247 publications

(225 citation statements)

References 24 publications

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“…In most studies reporting burst firing of dopamine neurons in response to reward or salient stimuli, the duration of stimuli is comparatively short, thus activations of dopamine cells are typically composed of only one time-locked burst (Dommett et al, 2005;Ungless et al, 2004, see also Schultz, 2002 for review). This form of activation is different from the sustained bursting that we observed in PS.…”

Section: Discussionmentioning

confidence: 99%

Prominent Burst Firing of Dopaminergic Neurons in the Ventral Tegmental Area during Paradoxical Sleep

Dahan

Astier

Vautrelle

et al. 2006

Neuropsychopharmacol

250

167

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Dopamine is involved in motivation, memory, and reward processing. However, it is not clear whether the activity of dopamine neurons is related or not to vigilance states. Using unit recordings in unanesthetized head restrained rats we measured the firing pattern of dopamine neurons of the ventral tegmental area across the sleep-wake cycle. We found these cells were activated during paradoxical sleep (PS) via a clear switch to a prominent bursting pattern, which is known to induce large synaptic dopamine release. This activation during PS was similar to the activity measured during the consumption of palatable food. Thus, as it does during waking in response to novelty and reward, dopamine could modulate brain plasticity and thus participate in memory consolidation during PS. By challenging the traditional view that dopamine is the only aminergic group not involved in sleep physiology, this study provides an alternative perspective that may be crucial for understanding the physiological function of PS and dream mentation.

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Section: Discussionmentioning

confidence: 99%

Prominent Burst Firing of Dopaminergic Neurons in the Ventral Tegmental Area during Paradoxical Sleep

Dahan

Astier

Vautrelle

et al. 2006

Neuropsychopharmacol

250

167

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“…This input raises the interesting possibility that dopamine cells receive a direct sensory projection. The collicular input has been suggested to be responsible for the short latency, burst-firing activity of the dopamine cells in response to a salient or rewarding stimuli (Dommett et al, 2005). Finally, in primates, there is a small and relatively limited projection from the PFC to the midbrain DA neurons in primates.…”

Section: Organization Of the Dopamine Neuronsmentioning

confidence: 99%

“…Although the short latency burst-firing activity of dopamine that signals immediate reinforcement is likely to be triggered from brainstem nuclei (Dommett et al, 2005), the cortico-striato-midbrain pathway is in the position to influence dopamine cells to distinguish rewards and modify responses to incoming salient stimuli over time. This pathway is further reinforced through the nigro-striatal pathway, placing the striato-nigro-striatal pathway in a pivotal position for transferring information from the VS to the dorsal striatum during learning and habit formation.…”

Section: Organization Of the Dopamine Neuronsmentioning

confidence: 99%

The Reward Circuit: Linking Primate Anatomy and Human Imaging

Haber

Knutson

2009

Neuropsychopharmacol

3,043

190

2,754

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Although cells in many brain regions respond to reward, the cortical-basal ganglia circuit is at the heart of the reward system. The key structures in this network are the anterior cingulate cortex, the orbital prefrontal cortex, the ventral striatum, the ventral pallidum, and the midbrain dopamine neurons. In addition, other structures, including the dorsal prefrontal cortex, amygdala, hippocampus, thalamus, and lateral habenular nucleus, and specific brainstem structures such as the pedunculopontine nucleus, and the raphe nucleus, are key components in regulating the reward circuit. Connectivity between these areas forms a complex neural network that mediates different aspects of reward processing. Advances in neuroimaging techniques allow better spatial and temporal resolution. These studies now demonstrate that human functional and structural imaging results map increasingly close to primate anatomy.

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“…The latency between the presentation of the reward stimuli and the activity of the DA cells is too short to reflect higher cortical processing necessary for linking a stimulus with its rewarding properties. The fast, burst-firing activity is likely, therefore, to be generated from other input such as in the brainstem glutamatergic nuclei (Dommett et al, 2005). However, a critical issue is, how do the dopamine cells receive information concerning reward value?…”

Section: The Role Of the Diffuse Projectionsmentioning

confidence: 99%

Reward-Related Cortical Inputs Define a Large Striatal Region in Primates That Interface with Associative Cortical Connections, Providing a Substrate for Incentive-Based Learning

Haber¹,

Kim²,

Mailly³

et al. 2006

J. Neurosci.

626

598

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The anterior cingulate and orbital cortices and the ventral striatum process different aspects of reward evaluation, whereas the dorsolateral prefrontal cortex and the dorsal striatum are involved in cognitive function. Collectively, these areas are critical to decision making. We mapped the striatal area that receives information about reward evaluation. We also explored the extent to which terminals from reward-related cortical areas converge in the striatum with those from cognitive regions. Using three-dimensional-rendered reconstructions of corticostriatal projection fields along with two-dimensional chartings, we demonstrate the reward and cognitive territories in the primate striatum and show the convergence between these cortical inputs. The results show two labeling patterns: a focal projection field that consists of densely distributed terminal patches, and a diffuse projection consisting of clusters of fibers, extending throughout a wide area of the striatum. Together, these projection fields demonstrate a remarkably large, rostral, reward-related striatal territory that reaches into the dorsal striatum. Fibers from different reward-processing and cognitive cortical areas occupy both separate and converging territories. Furthermore, the diffuse projection may serve a separate integrative function by broadly disseminating general cortical activity. These findings show that the rostral striatum is in a unique position to mediate different aspects of incentive learning. Furthermore, areas of convergence may be particularly sensitive to dopamine modulation during decision making and habit formation.

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How Visual Stimuli Activate Dopaminergic Neurons at Short Latency

Cited by 247 publications

References 24 publications

Prominent Burst Firing of Dopaminergic Neurons in the Ventral Tegmental Area during Paradoxical Sleep

Prominent Burst Firing of Dopaminergic Neurons in the Ventral Tegmental Area during Paradoxical Sleep

The Reward Circuit: Linking Primate Anatomy and Human Imaging

Reward-Related Cortical Inputs Define a Large Striatal Region in Primates That Interface with Associative Cortical Connections, Providing a Substrate for Incentive-Based Learning

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