How to treat a fulminant erysipelas and sepsis caused by Myroides odoratimimus: case report and literature review

Abstract

We report a case of a 77-year old male who developed a fulminant erysipelas and sepsis, caused by Myroides odoratimimus. Selecting the optimal antibiotic therapy for the treatment of infections with M. odoratimimus is challenging due to limited clinical experience with this micro-organism and its reported multidrug-resistance. Review of previous studies concerning in vitro antibacterial susceptibility and clinical experience with M. odoratimimus resulted in six case reports describing bacteremia, soft tissue and bone infections, pneumonia and urinary tract infections. In vitro susceptibility to aminoglycosides, fluoroquinolones and trimethoprim/sulfamethoxazole is variable. Treatment of M. odoratimimus infections should be based on antimicrobial susceptibility testing results. In a majority of the case reports, including the present one, treatment with fluoroquinolones proved to be a good therapeutic option.

<p>A Confirmed Catheter-Related Blood Stream Infection (CRBSI) in an Immunocompetent Patient Due to <em>Myroides odoratimimus</em>: Case Report and Literature Review</p>

“…35 Open wounds with exposure to water can be considered as a risk factor to cause rapidly invasive Myroides infections, regardless of the immunity of patients. Maraki et al reported a healthy child developed cellulitis after a pig bite, 9 while Willems et al describe a case of fulminant erysipelas with sepsis following a scratch of the domestic dog in a corticosteroid-treated host, 36 the two cases above indicated that animal attacks on people may be another risk factor to cause the infections of Myroidesspp.…”

“…30 Many strains have been recognized as resistant to beta-lactams, monobactams and carbapenems due to the production of chromosomeencoded metallo-β-lactamase (MUS-1 and TUS-1), 36 Myroides odoratimimus is intrinsically resistant to colistin. 36 In addition, a new subclass B1 metallo-β-lactamase gene bla MOC was found which also conferred resistance to most beta-lactams except for aztreonam and cefepime. 38 There was another report described MUS-2, a novel variant of the chromosome-encoded β-lactamase MUS-1, reducing the susceptibility to beta-lactams.…”

Comparative genomic analysis of Myroides odoratimimus isolates

“…It causes a variety of serious infections mainly reported in China (summarized by Hu et al, 2016) and outbreak of urinary tract infection (Ktari et al, 2012). Recently, the increasing infections emerged in patients with the recurrent calcaneal ulcer (Pompilio et al, 2017), fulminant erysipelas and sepsis (Willems, Muller, Verhaegen, Saegeman, & Desmet, 2017), bacteremia (Belloir, Billy, Hentgen, Fille, & Barrans, 2016), or prosthesis joint infection (Jover-Sáenz, Pérez-Villar, & Barcenilla-Gaite, 2016).…”

Association ofMyroides odoratimimusin immunocompromized piglets with post weaning multisystemic wasting syndrome

“…Hospital‐acquired infections in immunocompromised humans caused by M . odoratimimus range from erysipelas and soft tissue infections to septicaemia leading to septic shock (Benedetti et al ; Ktari et al ; Maraki et al ; Beharrysingh, ; Willems et al ; Licker et al ). The association of M .…”

“…Hospital-acquired infections in immunocompromised humans caused by M. odoratimimus range from erysipelas and soft tissue infections to septicaemia leading to septic shock (Benedetti et al 2011;Ktari et al 2012;Maraki et al 2012;Beharrysingh, 2017;Willems et al 2017;Licker et al 2018). The association of M. odoratimimus in post pig bite wound infections in immunocompromised individuals has been reported (Goldstein et al 1990;Maraki et al 2012).…”