&lt;p&gt;A Confirmed Catheter-Related Blood Stream Infection (CRBSI) in an Immunocompetent Patient Due to &lt;em&gt;Myroides odoratimimus&lt;/em&gt;: Case Report and Literature Review&lt;/p&gt;

Lu, Yanfei; Xia, Wenying; Zhang, Xiaohui; Ni, Fang; Mei, Yaning

doi:10.2147/idr.s234778

Cited by 11 publications

(17 citation statements)

References 42 publications

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“…They are found in soil and water. Although they rarely cause infections, skin and soft tissuse infections, bacteremia and urinary tract infections have been reported [1][2][3][4][5]. Myroides spp.…”

Section: Introductionmentioning

confidence: 99%

A pan-resistant Myroides odoratimimus catheter-related bacteremia in a COVID-19 patient and review of the literature

Kurt

Mete

Houssein

et al. 2022

AMicr

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Myroides spp. are opportunistic environmental Gram-negative bacteria. These affect mostly immunocompromised hosts and generally lead to soft tissue, and urinary tract infections. Bacteremia most commonly develop secondary to soft tissue or catheter related infections and may lead rarely to mortality. Myroides spp. are generally suscetible to fluoroquinolones, piperacillin/tazobactam, trimethoprim/sulfamethoxazole, carbapenems or tetracyclines however, pan-resistant isolates and multiple resistance genes have been reported in clinical isolates of Myroides spp. We report a pan-resistant Myroides odoratimimus bacteremia in a patient with severe COVID-19 ending with fatality and in this context a review of reported Myroides bacteremias are also described. In this study, a 64-year old male patient with history of coronary artery bypass was admitted to ICU with severe COVID-19 pneumonia accompanied by pneumomediastinum and pneumopericardium. Continous renal replacement therapy and extracorporeal membraneous-oxygenation were initiated due to acute renal failure and persistent hypercarbia/hypoxia, respectively. Within four weeks of hospitalization various episodes of bacteremia developed and multiple antibiotics were used. On the 5th week of follow-up, acute phase reactants increased and empirical broad spectrum antibiotics were initiated. Blood culture revealed Gram-negative rods. The patient became hypotensive and despite maximum medical care he was lost due to cardiac arrest. M. odoratimimus was identified by MALDI-TOF and the bacterium was pan-resistant. According to Center for Genomic Epidemiology results the strain was identified as M. odoratimimus PR63039 and the genome analysis revealed antibiotic resistance genes associated with resistance to beta-lactams (bla OXA-347, bla MUS-1, bla EBR-1), tetracyclines (tetX), sulfonamides (sul2), macrolides (ereD), (ermF).

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Section: Introductionmentioning

confidence: 99%

A pan-resistant Myroides odoratimimus catheter-related bacteremia in a COVID-19 patient and review of the literature

Kurt

Mete

Houssein

et al. 2022

AMicr

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“…This report is presented to add to the few, but growing, number of cases of pathogenic Myroides spp. in immunocompetent individuals described previously by Lu and colleagues [ 5 ]. In those cases, an environmental source was identified as a possible route of Myroides spp.…”

Section: Discussionmentioning

confidence: 99%

“…Along with advancements in molecular assay testing, there are growing reports of clinically relevant Myroides spp. infections in immunocompetent individuals [ 1 , 5 , 6 ]. The described pathogens demonstrate intrinsic broad-spectrum antimicrobial resistance with some isolates displaying the ability to produce biofilms, though the underlying mechanisms of resistance are still being studied [ 6 – 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…is considered ubiquitous as their natural reservoir is the aquatic environment, with newer species being identi ed in seawater; they are not, however, part of typical human micro ora. Since their reclassi cation, eighteen species and two subspecies have been identi ed with only four, primarily M. odoratus and M. odoratimimus, being implicated in human infections [2][3][4][5]. Myroides spp.…”

Section: Introductionmentioning

confidence: 99%

“…Along with advancements in molecular assay testing, there are growing reports of clinically relevant Myroides spp. infections in immunocompetent individuals [1,5,6].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Extensively Drug-Resistant Myroides odoratus in Critically Ill Patients: A Case Series and Literature Review

O’Neal

Labay

Harris

et al. 2022

Case Reports in Infectious Diseases

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The bacterial genus Myroides, like other members of the Flavobacteriaceae family, consists of aerobic, non-motile, Gram-negative bacilli. Myroides spp. is considered predominantly opportunistic pathogens as, historically, most documented infections have been in immunocompromised individuals. Along with advancements in molecular assay testing, there are growing reports of clinically relevant Myroides spp. infections in immunocompetent individuals. These organisms display broad antimicrobial resistance, and while research into their mechanisms of resistance is progressing, genetic testing has revealed metallo-β-lactamases present in their genome. The sporadic identification of Myroides spp. and ongoing clarification of resistance patterns make empiric treatment difficult. This report documents two cases of extensively drug-resistant Myroides odoratus isolated from critically ill but otherwise immunocompetent patients followed by a review of available literature on Myroides spp. antibiotic sensitivities. Our findings indicate that minocycline and moxifloxacin have the highest documented in vitro activity against Myroides spp.

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Molecular characterization of the multi-drug resistant Myroides odoratimimus isolates: a whole genome sequence-based study to confirm carbapenem resistance

Yartasi,

Durmaz,

Ari

et al. 2023

Int Microbiol

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The bacteria belonging to the Myroides genus are opportunistic pathogens causing community or hospital-acquired infections that result in treatment failure due to antibiotic resistance. This study aimed to investigate molecular mechanisms of antibiotic resistance, clonal relatedness, and the bio lm forming capacity of the 51 multi-drug resistant Myroides odoratimimus. All isolates were screened for blaKPC, blaOXA, blaVIM, blaIMP, blaMUS, blaTUS, blaNDM, and blaB genes by using PCR ampli cation. Whole genome sequencing (WGS) was applied on three isolates for further investigation of antibiotic resistance mechanisms. Clonal relatedness was analyzed by Pulsed-eld gel electrophoresis (PFGE) and the microtiter plate method was used to demonstrate bio lm formation. All isolates were positive for bio lm formation. PCR analysis resulted in a positive for only the blaMUS-1 gene. WGS identi ed blaMUS-1, erm(F), ere(D), tet(X), and sul2 genes in all strains tested. PFGE yielded a clustering rate of 96%. High clonal relatedness, bio lm formation, and multi-drug resistance properties may lead to the predominance of these opportunistic pathogens in hospital environments and make them cause nosocomial infections.

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<p>A Confirmed Catheter-Related Blood Stream Infection (CRBSI) in an Immunocompetent Patient Due to <em>Myroides odoratimimus</em>: Case Report and Literature Review</p>

Cited by 11 publications

References 42 publications

A pan-resistant Myroides odoratimimus catheter-related bacteremia in a COVID-19 patient and review of the literature

A pan-resistant Myroides odoratimimus catheter-related bacteremia in a COVID-19 patient and review of the literature

Extensively Drug-Resistant Myroides odoratus in Critically Ill Patients: A Case Series and Literature Review

Molecular characterization of the multi-drug resistant Myroides odoratimimus isolates: a whole genome sequence-based study to confirm carbapenem resistance

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