How to substantiate eradication of bovine brucellosis when aspecific serological reactions occur in the course of brucellosis testing

Godfroid, Jacques; Saegerman, Claude; Wellemans, Vincent; Walravens, Karl; Letesson, J.J.; Tibor, Anne; Millan, Alastair Mc; Spencer, Steve; Sanna, Moez; Bakker, Douwe; Pouillot, Régis; Garin‐Bastuji, Bruno

doi:10.1016/s0378-1135(02)00230-4

Cited by 118 publications

(101 citation statements)

References 22 publications

Supporting

Mentioning

100

Contrasting

Unclassified

Order By: Relevance

“…Serological cross-reactions due to Yersinia enterocolitica were unlikely to influence these results because that pathogen is assumed to be rare or absent in the tropical region (Murry et al, 1999) and partly because there was no evidence of contact between cattle and either domestic or wild pigs (Godfroid et al, 2002). In addition, the use of specific tests such as c-ELISA results in a substantial decrease in the number of such cross-reactors (Nielsen et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of antibodies to Brucella spp. and individual risk Factors of Infection in Traditional Cattle, Goats and Sheep Reared in Livestock–Wildlife Interface Areas of Zambia

Muma

Samui

Siamudaala

et al. 2006

Trop Anim Health Prod

112

View full text Add to dashboard Cite

Please cite the article as: Muma, J.B., Samui, K.L., Siamudaala, V.M., Oloya, J., Matope, G., Omer, M.K., Munyeme, M., Mubita, C., Skjerve, E., 2006. Prevalence of antibodies to Brucella spp. and individual risk factors of infection in traditional cattle, goats and sheep reared in livestock-wildlife interface areas of Zambia. Tropical Animal Health and Production,. 2 AbstractA cross-sectional study was performed in the livestock-wildlife interface areas of Lochinvar and Blue Lagoon National Parks and the non-interface area of Kazungula to determine the prevalence of antibodies to Brucella spp. in domestic ruminants and identify individual animal risk factors of infection. Atotal of 1245 cattle from 124 herds and 280 goats and sheep from 29 flocks were tested sequentially for Brucella antibodies using the Rose Bengal test (RBT) and competitive ELISA. In cattle, individual seroprevalence ranged from 14.1% to 28.1%, while herd sero-prevalence ranged from 46.2% to 74.0% in the three study areas. No goat or sheep tested positive for Brucella antibodies. Three types of cattle grazing strategies were encountered: locally grazed herds (LGH), transhumantly grazed herds (TGH) and river flood plain grazed herds (FGH). Brucella seroprevalence was seen to vary according to area and grazing strategy: Lochinvar and transhumant grazed herds recorded the highest figures, respectively. Age, sex and history of abortion were found to have independent effects on individual seroprevalence. This study establishes that brucellosis is endemic in domestic animals in the livestock-wildlife interface areas of Blue Lagoon and Lochinvar national parks and the disease is also present in Kazungula. We observed that type of grazing strategy had significant impact on cattle Brucella seroprevalence and that transhumant herds were at high risk of being infected.

show abstract

Section: Discussionmentioning

confidence: 99%

Prevalence of antibodies to Brucella spp. and individual risk Factors of Infection in Traditional Cattle, Goats and Sheep Reared in Livestock–Wildlife Interface Areas of Zambia

Muma

Samui

Siamudaala

et al. 2006

Trop Anim Health Prod

112

View full text Add to dashboard Cite

show abstract

“…Thus, in countries virtually free of animal brucellosis and in the absence of an established epidemiological link, human brucellosis can virtually be ruled out and positive serological results have to be classified as false positive serological results [43]. False positive serological reactions in animal brucellosis are well documented in EU Member States virtually free of animal brucellosis and they represent currently one of the most important problems the veterinary authorities have to deal with [42].…”

Section: Case Classificationmentioning

confidence: 99%

“…Frequent contact between wild boar and cattle have been reported and the risk of cattle being exposed to B. suis biovar 2 has been assessed under field [5] and experimental conditions [42]. B. suis biovar 2 does not persit in cattle (self-cure mechanism) [42]. Hares have also been suspected to be the source of contamination of a cow in Denmark, a country where there are no freeranging wild boar populations [5].…”

Section: B Suis Biovarmentioning

confidence: 99%

From the discovery of the Malta fever?s agent to the discovery of a marine mammal reservoir, brucellosis has continuously been a re-emerging zoonosis

et al. 2005

Self Cite

View full text Add to dashboard Cite

-Brucellosis is not a sustainable disease in humans. The source of human infection always resides in domestic or wild animal reservoirs. The routes of infection are multiple: foodborne, occupational or recreational, linked to travel and even to bioterrorism. New Brucella strains or species may emerge and existing Brucella species adapt to changing social, cultural, travel and agricultural environment. Brucella melitensis is the most important zoonotic agent, followed by Brucella abortus and Brucella suis. This correlates with the fact that worldwide, the control of bovine brucellosis (due to B. abortus) has been achieved to a greater extent than the control of sheep and goat brucellosis (due to B. melitensis), these latter species being the most important domestic animals in many developing countries. The long duration and high cost of treatment of human brucellosis reduces the efficacy of the therapy. There is no human vaccine for brucellosis and the occurrence of brucellosis is directly linked to the status of animal brucellosis in a region. In this context, the Word Health Organization has defined the development of a human vaccine, besides the implementation of control and eradication programs in animals, as a high priority. The pathogenicity for humans of B. suis biovars 1, 3 and 4 is well established, whereas B. suis biovar 2 seems to be less pathogenic. Indeed, although hunters and pig farmers have repeatably experienced infectious contact with B. suis biovar 2 (found in wild boar and outdoor-rearing pigs in Europe), isolation of B. suis biovar 2 from human samples have only been seldom reported. Marine mammal brucellosis, due to two new proposed Brucella species i.e. B. cetaceae and B. pinnipediae, represents a new zoonotic threat but the pathogenicity for humans of the different Brucella species found in cetaceans and pinnipeds still has to be clearly established.Brucella / animal and human brucellosis / zoonoses / domestic and wildlife reservoir

show abstract

“…Overall, serologic tests are an ideal first line test. One major drawback are organisms that share the sLPS ( Yersinia enterocoloitica, Vibrio cholerae, Ochrobactrum anthropi, Salmonella enterica serotype Urbana, Franisella tularensis , and Escherichia coli O157:H7 ) and cross-react on these tests [90–92]. As with all serologic assays, presence of antibodies indicates exposure, but not necessarily present infection.…”

Section: Diagnosticsmentioning

confidence: 99%

Comparisons of brucellosis between human and veterinary medicine

Hull

Schumaker

2018

Infection Ecology & Epidemiology

119

110

View full text Add to dashboard Cite

Brucellosis is the world’s most widespread zoonosis, but also ranks as one of the seven most neglected diseases, according to the World Health Organization. Additionally, it is recognized as the world’s most common laboratory-acquired infection. There are a reported 500,000 incident cases of human brucellosis per year. However, true incidence is estimated to be 5,000,000 to 12,500,000 cases annually. Once diagnosed, focus is directed at treating individual patients with antibiotic regimes, yet overall neglecting the animal reservoir of disease. Countries with the highest incidence of human brucellosis are Syria (1,603.4 cases per 1,000,000 individuals), Mongolia (391.0), and Tajikistan (211.9). Surveillance on animal populations is lacking in many developed and developing countries. According to the World Animal Health Information Database, Mexico had the largest number of reported outbreaks, 5,514 in 2014. Mexico is followed by China (2,138), Greece (1,268), and Brazil (1,142). The majority of these outbreaks is Brucella abortus, the etiologic agent of bovine brucellosis. Brucellosis is an ancient disease that still plagues the world. There are still knowledge gaps and a need for better diagnostics and vaccines to make inroads towards control and eradication.

show abstract

How to substantiate eradication of bovine brucellosis when aspecific serological reactions occur in the course of brucellosis testing

Cited by 118 publications

References 22 publications

Prevalence of antibodies to Brucella spp. and individual risk Factors of Infection in Traditional Cattle, Goats and Sheep Reared in Livestock–Wildlife Interface Areas of Zambia

Prevalence of antibodies to Brucella spp. and individual risk Factors of Infection in Traditional Cattle, Goats and Sheep Reared in Livestock–Wildlife Interface Areas of Zambia

From the discovery of the Malta fever?s agent to the discovery of a marine mammal reservoir, brucellosis has continuously been a re-emerging zoonosis

Comparisons of brucellosis between human and veterinary medicine

Contact Info

Product

Resources

About