How to Predict HCC Development in Patients with Chronic B Viral Liver Disease?

Han, Kwang Hyub; Ahn, Sang Hoon

doi:10.1159/000082091

Cited by 48 publications

(49 citation statements)

References 58 publications

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“…In Japan HBsAg-positive cases of HCC constituted 42% in 1977HCC constituted 42% in -1978HCC constituted 42% in , but reduced to 15.5% in 2000HCC constituted 42% in -2001 reported by the Liver Cancer Study Group of Japan (Kim et al, 2008). In Korea approximately 65-75% of HCC patients are positive for HBsAg and the high incidence rate of HCC in this country is related to the high carrier rate of HBV in the general population (Sin et al, 1996;Han and Ahn, 2005;Park and Kim, 2008).…”

Section: Role Of Hbvmentioning

confidence: 97%

Burden of Hepatocellular Carcinoma in Asia

Fazeli¹,

Pourhoseingholi²,

Vahedi³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Hepatocellular carcinoma (HCC), the sixth most prevalent cancer worldwide, continues to have high prevalence example in China. HBV vaccination should be the major preventive tactic in Asian countries. The burden of HCC is low in Iran because most cases are due to HBV and this infection was less common. Although in Iran, a mass vaccination program started in 1993, its impact on decreasing the burden of HCC due to HBV can only be expected in future decades.

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Section: Role Of Hbvmentioning

confidence: 97%

Burden of Hepatocellular Carcinoma in Asia

Fazeli¹,

Pourhoseingholi²,

Vahedi³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…Chronic carriers of HBV have up to a 30-fold increased risk of HCC [16]. Clinical, pathological, epidemiological, molecular, and animal studies clearly show that HBV infection is the most important risk factor for HCC and that it is the etiology underlying approximately 50% of all cases [17,18]. Viral factors associated with a greater risk of HCC include HBeAg positivity, serum HBV DNA levels, and HBV genotypes.…”

Section: Hcc Is a Potentially Fatal Consequence Of Hbv Infectionmentioning

confidence: 99%

Decreased expression of Small glutamine-rich tetratricopeptide repeat-containing protein (SGT) correlated with prognosis of Hepatocellular carcinoma

Zhang¹,

Chen²,

He³

et al. 2014

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Small glutamine-rich tetratricopeptide repeat-containing protein (SGT) is an ubiquitously expressed cochaperone of heat shock cognate protein of 70 kDa (Hsc70). SGT binds to the C terminus of Hsc70 to recruit Hsc70 into complexes of diverse function. SGTB was identified as an isoform of SGT with 60% amino acid sequence homology. To investigate the expression of SGTB in hepatocellular carcinoma (HCC) and determine its correlation with tumor progression and prognosis, we evaluated the expression levels of SGTB in HCCs and corresponding adjacent non-tumor liver tissues. We also assessed the association between their expression and clinicopathologic parameters. The expression of SGTB was absent or low in HCCs while it was notable in paracancerous tissues from 108 patients by western blotting and immunochemistry (P < 0.05). Among the 108 HCCs, low expression of SGTB was associated with gender, histological grade (P<0.001) and HBsAg expression (P=0.002). Univariate analysis showed that the low SGTB expression was associated with poor prognosis (P<0.001). Thus, decreased expression of SGTB may be a favorable independent poor prognostic parameter for hepatocellular carcinoma.

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“…Approximately 65–75% of HCC patients are positive for HBsAg, and 10–20% for antibody to HCV (anti-HCV). Half of the HCC patients, negative to both HBsAg and anti-HCV, are habitual and heavy alcohol drinkers [12,13,14]. The high incidence rate of HCC is thought to be related to the high carrier rate of HBV in the general population.…”

Section: Factors Related To Hcc Occurrencementioning

confidence: 99%

Epidemiology of Hepatocellular Carcinoma in Japan and Korea

et al. 2008

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The worldwide burden of liver cancer has been estimated at 671,000 new cases for the year 2005. Hepatocellular carcinoma (HCC) accounts for between 85 and 90% of primary liver cancer and is one of the most frequent malignancies in Asia. In both Japan and Korea, the incidence exceeds 25 cases/100,000/year and ranks third in cancer deaths after stomach and lung cancer. In Korea the number of deaths from liver cancer increased from approximately 5,789 in 1983 to 9,966 in 1994, and then remained steady at 9,500/100,000 in 2003. In Japan the number of deaths from HCC increased until 2002, and then decreased to 34,089 in 2003, up to 15% of HCC cases are caused by hepatitis B virus (HBV) and ∼80% by hepatitis C virus (HCV) infection; the corresponding figures in Korea are ∼70 and ∼20%. Recent clinical data have shown that interferon and lamivudine treatment is effective in preventing the occurrence of HCC attributed to HCV and HBV infection, respectively, and that an aggressive vaccination program against the latter reduces the incidence of HCC. With the enormous efforts of researchers devoted to basic and clinical studies, the incidence of HCC is expected, in the near future, to gradually decline in both countries.

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How to Predict HCC Development in Patients with Chronic B Viral Liver Disease?

Cited by 48 publications

References 58 publications

Burden of Hepatocellular Carcinoma in Asia

Burden of Hepatocellular Carcinoma in Asia

Decreased expression of Small glutamine-rich tetratricopeptide repeat-containing protein (SGT) correlated with prognosis of Hepatocellular carcinoma

Epidemiology of Hepatocellular Carcinoma in Japan and Korea

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