How to Perform and Interpret Functional Magnetic Resonance Imaging Studies in Functional Gastrointestinal Disorders

Lee, In Seon; Preißl, Hubert; Enck, Paul

doi:10.5056/jnm16196

Cited by 10 publications

(6 citation statements)

References 91 publications

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“…These sensory experiences are associated with pleasant or occasionally unpleasant sensations (changes in mood and digestive well-being), i.e., the hedonic dimension of the sensory experience [12][13][14]18,19]. Changes in the activity of the central nervous system (CNS) in response to meal ingestion have been documented by means of functional brain imaging (e.g., functional magnetic resonance imaging and positron emission tomography) [20][21][22][23][24][25][26]. These studies reveal the crucial role of the CNS in the control of food intake and the conscious perception of sensation and in the maintenance of homeostasis [27].…”

Section: Food Ingestion and The Brain-gut Axismentioning

confidence: 99%

Food, Eating, and the Gastrointestinal Tract

2020

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Food ingestion induces a metered response of the digestive system. Initially, the upper digestive system reacts to process and extract meal substrates. Later, meal residues not absorbed in the small bowel, pass into the colon and activate the metabolism of resident microbiota. Food consumption also induces sensations that arise before ingestion (e.g., anticipatory reward), during ingestion (e.g., gustation), and most importantly, after the meal (i.e., the postprandial experience). The postprandial experience involves homeostatic sensations (satiety, fullness) with a hedonic dimension (digestive well-being, mood). The factors that determine the postprandial experience are poorly understood, despite their potential role in personalized diets and healthy eating habits. Current data suggest that the characteristics of the meal (amount, palatability, composition), the activity of the digestive system (suited processing), and the receptivity of the eater (influenced by multiple conditioning factors) may be important in this context.

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Section: Food Ingestion and The Brain-gut Axismentioning

confidence: 99%

Food, Eating, and the Gastrointestinal Tract

2020

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“…[43][44][45][46] In humans, changes in brain activity can be detected by different methods, such as functional magnetic resonance imaging and positron emission tomography. [47][48][49] The central nervous system plays a key role in homeostasis, control of food intake and perception of conscious sensations. 50…”

Section: Somatic and Homeostatic Responsesmentioning

confidence: 99%

Biogastronomy: Factors that determine the biological response to meal ingestion

Pribić

Azpiroz

2018

Neurogastroenterology Motil

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The aim of this narrative review is to provide a comprehensive overview and to define the framework to investigate the factors that determine the postprandial experience. Based on a series of proof-of-concept studies and related information, we propose that the biological responses to a meal depend on the characteristics of the meal, primarily its palatability and composition, and the responsiveness of the guest, which may be influenced by multiple previous and concurrent conditioning factors. This information provides the scientific backbone to the development of personalized gastronomy.

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“…Since this disease does not show obvious abnormalities of biochemical indicators, it is a functional disease ( 3 ). According to the statistics, the morbidity of IBS in the world is 5–20%, and the morbidity in Asia is 6.5–10.1% ( 4 , 5 ). The morbidity of IBS which conforms to Manning criteria in China is 22.8% and the morbidity is related to the stress of life and the pace of work ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

Expression and clinical significance of 5‑HT and 5‑HT3R in the intestinal mucosa of patient with diarrhea‑type irritable bowel syndrome

Chen

Chen³

et al. 2019

Exp Ther Med

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Expression levels and clinical significance of 5-HT and 5-HT3R in the intestinal mucosa tissue of patients with diarrhea-type irritable bowel syndrome (D-IBS) were investigated. A retrospective analysis was performed on 46 tissue specimens (observation group) of the intestinal mucosa of patients with D-IBS, who were diagnosed in the Tongde Hospital of Zhejiang Province and received colonoscopy from March 2016 to December 2017, and 18 tissue specimens (control group) of the intestinal mucosa of healthy subjects who received physical examinations. The expression levels of 5-HT and 5-HT3R in the intestinal mucosa tissue of patients in the observation and control group were detected by ELISA, and the relationship between 5-HT, 5-HT3R and the clinicopathological parameters of patients with D-IBS was analyzed. Pearson's correlation analysis was used to analyze the correlation of 5-HT and 5-HT3R in the intestinal mucosa tissue of patients with D-IBS. The expression levels of 5-HT and 5-HT3R in the intestinal mucosa tissue of patients in the observation group were significantly higher than those of the patients in the control group (344.86±67.52 ng/ml and 13.04±8.34 pg/ml) (P<0.001). There was a positive correlation between the expression level of 5-HT and the expression level of 5-HT3R in the intestinal mucosa tissue of patients with D-IBS (r=0.725, P<0.001). The expression levels of 5-HT and 5-HT3R in the intestinal mucosa tissue of patients with D-IBS were both significantly higher than those of the healthy subjects. The expression levels of 5-HT and 5-HT3R in patients with D-IBS were correlated with age, sex and the history of gastrointestinal infection. 5-HT and 5-HT3R may be involved in the pathogenesis of D-IBS, and potentially used for clinical treatment.

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How to Perform and Interpret Functional Magnetic Resonance Imaging Studies in Functional Gastrointestinal Disorders

Cited by 10 publications

References 91 publications

Food, Eating, and the Gastrointestinal Tract

Food, Eating, and the Gastrointestinal Tract

Biogastronomy: Factors that determine the biological response to meal ingestion

Expression and clinical significance of 5‑HT and 5‑HT3R in the intestinal mucosa of patient with diarrhea‑type irritable bowel syndrome

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