How the niche regulates hematopoietic stem cells

Renström, Jonas; Kröger, Monika; Peschel, Christian; Oostendorp, Robert A.J.

doi:10.1016/j.cbi.2009.11.012

Cited by 52 publications

(50 citation statements)

References 119 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Expression levels of ANGPT1 and KDR, the ligands of TIE2 and VEGFR, are of special interest because the related signaling pathways are important for the maintenance of quiescent HSCs and a physiologic HSC niche. 7 Consistently, the HLXB9/TEL gene expression profile revealed expression of early hematopoietic marker genes such as KITL and CD34, corresponding with the immunotypic findings. To further investigate the ability for malignant transformation of HLXB9/TEL or HLXB9 in comparison with MLL fusion proteins, we collected murine wild-type HSCs from 5-fluoruracil-treated mice and transduced the cells with a g-retroviral vector expressing MLL/ENL, HLXB9, HLXB9/TEL, HLXB9/TEL þ HLXB9 or an empty g-retroviral vector and subsequently plated the cells on methylcellulose.…”

mentioning

confidence: 63%

Expression of cell–cell interacting genes distinguishes HLXB9/TEL from MLL-positive childhood acute myeloid leukemia

et al. 2010

View full text Add to dashboard Cite

mentioning

confidence: 63%

Expression of cell–cell interacting genes distinguishes HLXB9/TEL from MLL-positive childhood acute myeloid leukemia

et al. 2010

View full text Add to dashboard Cite

“…Schofield was the first to propose that HSCs was in association with other cells which determine their behavior [1][2][3][4]. Such a niche composed of specialized cells capable of supporting stem cells.…”

Section: The Hematopoietic Stem Cells Nichementioning

confidence: 99%

The Interaction Between Niche and Hematopoietic Stem Cells

Wang

Tian²,

Zhang³

2016

Indian J Hematol Blood Transfus

View full text Add to dashboard Cite

Hematopoietic stem cells (HSCs) are one of the somatic stem cells that have the ability to regenerate the entire blood system in a hierarchical way for the duration of an adult life. HSCs reside in the bone marrow niche which contain different cells and molecules that regulate the balance of HSC dormancy and activation. Here, we describe the interaction between HSCs and their niche, in particularly the involvement of some signaling pathway. Insights into the hematopoietic microenvironment will help to obtain a better understanding of normal hematopoiesis and how environmental factors affect these processes.

show abstract

“…But the niche also adapts in times of hematopoietic stress. A failure to maintain a strict regulation of the hematopoietic cells can lead to a variety of malignancies such as leukemia, the most common form of cancer in humans (Renstrom et al, 2010).…”

Section: Hematopoietic Scsmentioning

confidence: 99%