“…The findings suggest that higher SDU-P scores were associated with more vascular events, such as venous thrombosis (DVT) and arterial thrombosis/hemorrhage (TIA, stroke). In line with our findings, others found associations of stroke with periodontitis [55] and tooth loss [56] and between periodontitis and recurrent vascular events in stroke/TIA patients [57]. Moreover, bacterial DNA from viridans streptococci, mostly of oral origin, was found in the aspired thrombi of patients with acute ischemic stroke [58].…”
Section: Associations Of Sdu-p and Sdu-d With Health-related Habitssupporting
There are conflicting results existing regarding the association between dental status and metabolic syndrome (MetS). The present research analyzed the associations of the sum of the standard dental unit (SDU) scores of planned (SDU-P) and delivered (SDU-D) dental procedures per patient with MetS components, consequences, and related conditions. The SDU score of each dental procedure represents the time and complexity of the executed procedure. This cross-sectional study analyzed data from the Dental, Oral, Medical Epidemiological (DOME) repository, which includes comprehensive socio-demographic, medical, and dental databases of a nationally representative sample of 132,529 military personnel. Univariate analyses revealed that SDU-P had statistically significant positive associations with all systemic morbidities related to MetS, while the SDU-D exhibited positive associations with some of the systemic morbidities and with lower ORs. SDU-P and SDU-D were associated with worse scores of auxiliary examinations used in the assessment of MetS components. SDU-P retained significant positive associations in the multivariate analysis with impaired glucose tolerance (IGT) (OR = 7.40 (1.91–28.57)), deep vein thrombosis (DVT) (OR = 5.61 (1.53–20.83)), obstructive sleep apnea (OSA) (OR = 5.05 (2.40–10.63)), and fatty liver (OR = 1.82 (1.17–2.84)). In contrast, obesity was the only systemic parameter retaining a significant association with SDU-D following multivariate analysis (OR = 1.47 (1.23–1.76)). It can be concluded that SDU-P, but not SDU-D, is a better predictor of systemic morbidities related to MetS. In other words, MetS is associated with a higher dental treatment needs burden, rather than with dental treatments performed de facto. Dental and general health authorities should collaborate and share information and focus on reducing common health-related risk factors, such as smoking and sugar consumption, in particular among high-risk populations, such as immigrants and those with lower SES and rural locality.
“…The findings suggest that higher SDU-P scores were associated with more vascular events, such as venous thrombosis (DVT) and arterial thrombosis/hemorrhage (TIA, stroke). In line with our findings, others found associations of stroke with periodontitis [55] and tooth loss [56] and between periodontitis and recurrent vascular events in stroke/TIA patients [57]. Moreover, bacterial DNA from viridans streptococci, mostly of oral origin, was found in the aspired thrombi of patients with acute ischemic stroke [58].…”
Section: Associations Of Sdu-p and Sdu-d With Health-related Habitssupporting
There are conflicting results existing regarding the association between dental status and metabolic syndrome (MetS). The present research analyzed the associations of the sum of the standard dental unit (SDU) scores of planned (SDU-P) and delivered (SDU-D) dental procedures per patient with MetS components, consequences, and related conditions. The SDU score of each dental procedure represents the time and complexity of the executed procedure. This cross-sectional study analyzed data from the Dental, Oral, Medical Epidemiological (DOME) repository, which includes comprehensive socio-demographic, medical, and dental databases of a nationally representative sample of 132,529 military personnel. Univariate analyses revealed that SDU-P had statistically significant positive associations with all systemic morbidities related to MetS, while the SDU-D exhibited positive associations with some of the systemic morbidities and with lower ORs. SDU-P and SDU-D were associated with worse scores of auxiliary examinations used in the assessment of MetS components. SDU-P retained significant positive associations in the multivariate analysis with impaired glucose tolerance (IGT) (OR = 7.40 (1.91–28.57)), deep vein thrombosis (DVT) (OR = 5.61 (1.53–20.83)), obstructive sleep apnea (OSA) (OR = 5.05 (2.40–10.63)), and fatty liver (OR = 1.82 (1.17–2.84)). In contrast, obesity was the only systemic parameter retaining a significant association with SDU-D following multivariate analysis (OR = 1.47 (1.23–1.76)). It can be concluded that SDU-P, but not SDU-D, is a better predictor of systemic morbidities related to MetS. In other words, MetS is associated with a higher dental treatment needs burden, rather than with dental treatments performed de facto. Dental and general health authorities should collaborate and share information and focus on reducing common health-related risk factors, such as smoking and sugar consumption, in particular among high-risk populations, such as immigrants and those with lower SES and rural locality.
“…The impact of these findings is highly significant since severe periodontal destructions are associated with increased mortality rate [56,57], as well as with cerebrovascular events [6]. Moreover, periodontal disease can double the overall risk for IS [16]; oral/dental infections were independently associated with the severity of atherosclerosis [58]. In our study group, there was a high frequency of hypertension, dyslipidaemia and diabetes, which are important risk factors for coronary artery disease.…”
Section: Discussionmentioning
confidence: 77%
“…Nonetheless, the graphical representation highly suggests a redistribution of the cases based on the two classification systems. Although further research to evaluate the relationship between the severity of periodontitis and IS [16] is recommended, the present study could not address this issue since most of the patients were severely affected by periodontal disease. However, the current study should be seen as a model for future larger trials aimed at comparing the two classification systems in cases that do not belong to the severe ones.…”
Section: Discussionmentioning
confidence: 88%
“…53-5.41) of IS in periodontitis patients has been reported [10]. More recent information suggests that, globally, periodontitis patients have about twice greater chance of experiencing some type of stroke, as to having IS [16,17]. Therefore, it can be inferred that the reported association between IS and periodontitis [10][11][12][13]15,18] emphasizes the systemic implications of periodontitis [17].…”
Section: Introductionmentioning
confidence: 99%
“…Further studies are recommended to clarify the complex, albeit incompletely elucidated, pathogenic pathways between periodontitis and IS and to identify the relationship between the severity of the two diseases, the impact of the periodontal treatment and the influence of periodontitis on IS survival [16]. An important premise for further studies in this area of interest would be the use of an unanimously accepted case definition of the periodontal status in epidemiological investigations to allow comparisons between studies.…”
The identification of the associative relationships between ischemic stroke (IS) and risk factors such as advanced age and periodontitis is essential to design real screening protocols and to address them using primary and secondary preventive policies. This study primarily aimed to evaluate the diagnostic performance of the 2018 European Federation of Periodontology/American Academy of Periodontology (EFP/AAP) case definition in detecting periodontitis against the 2012 Centers for Disease Control and Prevention/American Academy of Periodontology (CDC/AAP) case definition in a group of IS patients. Secondarily, we report the periodontal status of IS patients and the associative relationship with respect to some risk factors. Patients with their first IS were assessed based on demographic data, medical, oral risk factors and periodontal parameters. The two case definitions were applied to identify the periodontitis burden. The agreement between the two case definition systems, as well as the misclassification ratio, were calculated. A total of 141 patients were included. According to the 2012 CDC/AAP and the 2018 EFP/AAP case definitions, a frequency of periodontitis of 98.5% and 97.8% based on two modalities of inclusion of cases in the severity groups, sensitivity values of 98.54% or 100%, and specificity values of 25% or 14.7% were calculated. Thus, the new case definition system has a higher capacity to detect periodontitis, especially the well-established forms.
Background and AimsCoronavirus disease (COVID‐19) is a major danger to world health and has been linked to periodontitis in a number of epidemiological observational studies. However, it is unclear whether COVID‐19 causes periodontitis. COVID‐19's causal influence on periodontitis was determined using bidirectional Mendelian randomization (MR).MethodsLarge‐scale COVID‐19 and periodontitis genome wide association study data were analyzed. Inverse variance weighting, MR‐Egger, weighted median, and MR‐PRESSO were used to estimate causal effects. Sensitivity studies were conducted using the Cochran's Q test, the MR‐Egger intercept test, the MR‐PRESSO, and the leave‐one‐out (LOO) analysis. Further investigation of potential mediating factors was performed using risk factor analysis.ResultsThe MR presented no causal relationship between periodontitis and hospitalization for COVID‐19 (odds ratio [OR] = 0.97, 95% confidence interval [CI] 0.78–1.20; p = 0.76), vulnerability to COVID‐19 (OR = 1.04, 95% CI 0.88–1.21; p = 0.65), COVID‐19 disease severity (OR = 1.01, 95% CI 0.92–1.11; p = 0.81). Meanwhile, a noncausal effect of genetic hospitalization for COVID‐19, illness severity, and vulnerability to periodontitis was detected. Other MR methods yielded identical results to inverse variance weighting. According to sensitivity analysis, horizontal pleiotropy is unlikely to affect causal estimation.ConclusionPeriodontitis had no link to the risk of COVID‐19 hospitalization, susceptibility, or severity. However, the substance in COVID‐19 that is responsible for this effect must be studied further.
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