Relationship between periodontitis and COVID‐19: A bidirectional two‐sample Mendelian randomization study

Song, Jukun; Wu, Yadong; Yin, Xinhai; Zhang, Junmei

doi:10.1002/hsr2.1413

Cited by 2 publications

(1 citation statement)

References 61 publications

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“…8,10 In addition, people with periodontitis were found to be more likely to have severe disease or die from COVID-19. 11-13 Collectively, these studies strongly suggests that oral microbiome dysbiosis or potentially specific oral pathogens that are associated with periodontitis could play a role in COVID-19 infection and disease severity.…”

Section: Introductionmentioning

confidence: 97%

Inhibition of SARS-CoV-2 infection byPorphyromonas gingivalisand the oral microbiome

Bontempo,

Chirino,

Heidari

et al. 2024

Preprint

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The COVID-19 pandemic persists despite the availability of vaccines, and it is therefore crucial to develop new therapeutic and preventive approaches. In this study, we investigated the potential role of the oral microbiome in SARS-CoV-2 infection. Using anin vitroSARS-CoV-2 pseudovirus infection assay, we found a potent inhibitory effect exerted byPorphyromonas gingivalison SARS-CoV-2 infection mediated by knownP. gingivaliscompounds such as phosphoglycerol dihydroceramide (PGDHC) and gingipains as well as by unknown bacterial factors. We found that the gingipain-mediated inhibition of infection is likely due to cytotoxicity, while PGDHC inhibited virus infection by an unknown mechanism. Unidentified factors present inP. gingivalissupernatant inhibited SARS-CoV-2 likely via the fusion step of the virus life cycle. We addressed the role of other oral bacteria and found certain periodontal pathogens capable of inhibiting SARS-CoV-2 pseudovirus infection by inducing cytotoxicity on target cells. In the human oral cavity, we observed the modulatory activity of oral microbial communities varied among individuals in that some saliva-based cultures were capable of inhibiting while others were enhancing infection. These findings contribute to our understanding of the complex relationship between the oral microbiome and viral infections, offering potential avenues for innovative therapeutic strategies in combating COVID-19.

show abstract

Section: Introductionmentioning

confidence: 97%

Inhibition of SARS-CoV-2 infection byPorphyromonas gingivalisand the oral microbiome

Bontempo,

Chirino,

Heidari

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Inhibition of SARS-CoV-2 infection by Porphyromonas gingivalis and the oral microbiome

Bontempo,

Chirino,

Heidari

et al. 2024

Microbiol Spectr

View full text Add to dashboard Cite

The COVID-19 pandemic persists despite the availability of vaccines, and it is, therefore, crucial to develop new therapeutic and preventive approaches. In this study, we investigated the potential role of oral microbiome in SARS-CoV-2 infection. Using an in vitro SARS-CoV-2 pseudovirus infection assay, we found a potent inhibitory effect exerted by Porphyromonas gingivalis on SARS-CoV-2 infection mediated by known P. gingivalis compounds such as phosphoglycerol dihydroceramide (PGDHC) and gingipains as well as by unknown bacterial factors. We found that the gingipain-mediated inhibition of infection is likely due to cytotoxicity, whereas PGDHC inhibited virus infection by an unknown mechanism. Unidentified factors present in P. gingivalis supernatant inhibited SARS-CoV-2 likely via the fusion step of the virus life cycle. We addressed the role of other oral bacteria and found certain periodontal pathogens capable of inhibiting SARS-CoV-2 pseudovirus infection by inducing cytotoxicity on target cells. In the human oral cavity, we observed that the modulatory activity of oral microbial communities varied among individuals, in that some saliva-based cultures were capable of inhibiting while others were enhancing infection. These findings contribute to our understanding of the complex relationship between the oral microbiome and viral infections, offering potential avenues for innovative therapeutic strategies in combating COVID-19. IMPORTANCE The oral microbiome is important in health and disease, and in this study, we addressed the potential role of the oral microbiome in COVID-19 infection. Our in vitro studies suggest that certain bacteria of the oral microbiome such as P. gingivalis produce compounds that could potentially inhibit SARS-CoV-2 infection. These findings elucidating the interactions between the oral microbiome and SARS-CoV-2 infection will be important in our understanding of COVID-19 pathogenesis and the development of innovative therapeutic and preventive strategies against COVID-19 infection.

show abstract

Relationship between periodontitis and COVID‐19: A bidirectional two‐sample Mendelian randomization study

Cited by 2 publications

References 61 publications

Inhibition of SARS-CoV-2 infection byPorphyromonas gingivalisand the oral microbiome

Inhibition of SARS-CoV-2 infection byPorphyromonas gingivalisand the oral microbiome

Inhibition of SARS-CoV-2 infection by Porphyromonas gingivalis and the oral microbiome

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