How Should Obesity be Measured and How Should Anesthetic Drug Dosage be Calculated?

Baerdemaeker, L.E.C. De; Limmen, J. G. M. Van; Nieuwenhove, Yves Van

doi:10.1007/978-88-470-2634-6_2

Cited by 4 publications

(1 citation statement)

References 77 publications

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“…Preoxygenation was followed by anesthesia induced with propofol, with or without rapid sequence induction (RSI), based upon the attending anesthesiologist's decision. Muscle relaxation for endotracheal intubation was provided with either succinylcholine (1 mg/kg total body weight [5]) for both RSI and non-RSI or with rocuronium 0.6 mg/kg for non-RSI and 1.2 mg/kg for RSI, dosed per ideal body weight [5].…”

Section: Methodsmentioning

confidence: 99%

Pre-selection of primary intubation technique is associated with a low incidence of difficult intubation in patients with a BMI of 35 kg/m2 or higher

Ezri

Waintrob

Avelansky

et al. 2018

Rom J Anaesth Int Care

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Section: Methodsmentioning

confidence: 99%

Pre-selection of primary intubation technique is associated with a low incidence of difficult intubation in patients with a BMI of 35 kg/m2 or higher

Ezri

Waintrob

Avelansky

et al. 2018

Rom J Anaesth Int Care

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show abstract

A Review of the Methods and Associated Mathematical Models Used in the Measurement of Fat-Free Mass

2018

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Fat-free mass (FFM) represents the lean component of the body devoid of fat. It has been shown to be a useful predictor of drug dose requirements, particularly in obesity where the excess fat mass does not contribute to drug clearance. However, measuring FFM involves complex and/or expensive experimental methodologies that preclude their use in routine clinical practice. Thus, models to predict FFM from readily measurable variables, such as body weight and height, have been developed and are used in both population pharmacokinetic modelling and clinical practice. In this review, methods used to measure FFM are explained and compared in terms of their assumptions, precision, and limitations. These methods are broadly classified into six different principles: densitometry, hydrometry, bioimpedance, whole-body counting, dual energy X-ray absorptiometry, and medical imaging. They vary in their processes and key biological assumptions that are often not applicable in certain populations (e.g. children, elderly, and certain disease states). This review provides a summary of the various methods of FFM measurement and estimation, and links these methods to a scientific framework to help clinicians and researchers understand the usefulness and potential limitations of these methods.

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Evaluating the Relationship Between Lean Liver Volume and Fat-Free Mass

et al. 2019

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How Should Obesity be Measured and How Should Anesthetic Drug Dosage be Calculated?

Cited by 4 publications

References 77 publications

Pre-selection of primary intubation technique is associated with a low incidence of difficult intubation in patients with a BMI of 35 kg/m2 or higher

Pre-selection of primary intubation technique is associated with a low incidence of difficult intubation in patients with a BMI of 35 kg/m2 or higher

A Review of the Methods and Associated Mathematical Models Used in the Measurement of Fat-Free Mass

Evaluating the Relationship Between Lean Liver Volume and Fat-Free Mass

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