Evaluating the Relationship Between Lean Liver Volume and Fat-Free Mass

Resting Energy Expenditure: From Cellular to Whole‐Body Level, a Mechanistic Historical Perspective

“…Instead, tissues for which no Ki value exist are frequently lumped into a large “residual” component that is then assigned an estimated Ki value; however, this introduces a source of error into REE estimation. A second limitation is that whole‐organ volumes evaluated with MRI cannot account for non‐metabolically active components such as blood, connective tissue, and fat that can be present in variable amounts in skeletal muscle, liver, and other organs (39). This variance can influence an organ’s density, a value now assumed constant when converting MRI‐measured volumes to mass.…”

“…That is one of several similar physiological responses that lead to a lower sleep REE than awake REE measured in the early morning. (39). This variance can influence an organ's density, a value now assumed constant when converting MRI-measured volumes to mass.…”

Allometric Scaling in Pharmacokinetic Studies in Anesthesiology

“…, where k is a proportionality constant and FFM is the fat-free mass predictor of Janmahasatian et al 14 If hepatic drug clearance is proportional to lean liver volume, 22 then this result supports the practice of using the West-Brown-Enquist model theoretic 0.75 exponent of body weight to scale hepatic drug clearance in pharmacokinetic models. Alternatively, predicted fat-free mass could be used with a correction factor for females.…”

“…It seems most applicable to peripheral compartments where clearances are intrinsic properties of the tissues represented by the compartments. evidence from the literature Sinha et al 22 examined lean liver volume (LLV) in humans using computerized tomography and found two equations consistent with the data: (1)…”

“…Sinha et al . 22 examined lean liver volume ( LLV ) in humans using computerized tomography and found two equations consistent with the data: (1) LLV = k · WGT 0.75 , and (2) LLV = k· FFM 1 ·(1.21 if female) , where k is a proportionality constant and FFM is the fat-free mass predictor of Janmahasatian et al 14 If hepatic drug clearance is proportional to lean liver volume, 22 then this result supports the practice of using the West–Brown–Enquist model theoretic 0.75 exponent of body weight to scale hepatic drug clearance in pharmacokinetic models. Alternatively, predicted fat-free mass could be used with a correction factor for females.…”