How often are endometrial polyps malignant in asymptomatic postmenopausal women? A multicenter study

Risk Factors Associated with the Malignant Changes of Symptomatic and Asymptomatic Endometrial Polyps in Premenopausal Women

“…These findings seem to be similar to those reported in previous studies in which malignancy rate was described to vary between 0.8 and 8 % [12,[19][20][21][22]. One study reported a high prevalence of hyperplasia without cytologic atypia (25.7 %) and a prevalence of hyperplasia with atypia (3.1 %), and it added that polyps represent a wide spectrum of alterations that range from normal endometrium to cancer [12].…”

“…Few studies have evaluated the relationship between polyp size and malignancy risk. Some authors have suggested that larger polyps are associated with a higher risk of malignancy [21,25]. However, others stated that polyp size is not a distinctive feature of malignancy [27,31].…”

“…AUB was found to be the significant predictor of polyp malignancy even in those populations with the lowest risk of malignancy (among premenopausal women) compared with asymptomatic women [21,25], but still women without vaginal bleeding harbor a risk of malignancy a possible explanation of this fact could be related to earlier diagnosis of polyps by transvaginal ultrasound that detects small polyps, as endometrial thickness, before they start bleeding.…”

Roles of Sonography and Hysteroscopy in the Detection of Premalignant and Malignant Polyps in Women Presenting with Postmenopausal Bleeding and Thickened Endometrium

“…In a retrospective multicenter study included 1155 asymptomatic and 770 consecutive postmenopausal women with abnormal uterine bleeding, it was found that polyps' size with mean of >18 mm was the only variable significantly associated to an abnormal histology (cancer, polypoid cancer, and atypical hyperplasia) in asymptomatic women (Lee et al, 2010). In a meta-analysis designed to analyze the oncogenic potential of endometrial polyps, four studies stated that larger polyps were directly associated with a greater risk of malignancy while the other four studies did not found any associations (Ferrazzi et al, 2009). More recently, Lasmar and Lasmar (2013) reported that endometrial polyps measuring more than 15mm were associated with hyperplasia.…”

“…Sabri Cavkaytar 1 , Mahmut Kuntay Kokanali 1 *, Ufuk Ceran 1 , Hasan Onur Topcu 1 , Levent Sirvan 2 , Melike Doganay 1 endometrial polyps increases with age, particularly in the postmenopausal period (Ben-Arie et al, 2004;Ferrazzi et al, 2009;Costa-Paiva et al, 2011;Uglietti et al, 2014). And also, endometrial carcinoma is one of the most curable cancers as detected in early stages (Binesh et al, 2014).…”