Benign Disease of the Uterus

Bosch, T. Van den

doi:10.1002/9781119211457.ch59

Cited by 5 publications

(7 citation statements)

References 54 publications

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“…Comprising large amounts of extracellular matrix (ECM), which includes collagen, fibronectin, and proteoglycans, fibroids present a complex biological structure [3,4] . Their prevalence is notably high, affecting 20-40% of women during their reproductive years and up to 70% by the age of 50, contributing to significant morbidity in about 30% of these cases [5,6] . Symptoms vary widely, ranging from heavy menstrual bleeding and anemia to pelvic pressure symptoms such as urinary discomfort and constipation [6] .…”

Section: Introductionmentioning

confidence: 99%

“…The FIGO classification system is employed to categorize fibroids based on their location, which assists in clinical reporting and management [7] . The incidence and growth of fibroids are known to increase with age [5] , and their development is influenced by various factors including racial differences, with Afro-Caribbean women at higher risk, and reproductive factors such as parity and use of oral contraceptives [8,9] . Environmental factors and lifestyle choices also play roles in fibroid development [8,9] .…”

Section: Introductionmentioning

confidence: 99%

“…The etiology of fibroids is multifactorial, involving genetic, hormonal, and environmental components. Clonal studies have shown that fibroids arise from individual myometrial cells, with growth influenced by ovarian steroids acting through receptors present on fibroid and myometrial cells [5] . Cytogenetic abnormalities, including translocations and deletions in specific chromosomes, have been identified in a significant proportion of fibroids, contributing to their ~ 6 ~ pathophysiology [5] .…”

Section: Introductionmentioning

confidence: 99%

“…Clonal studies have shown that fibroids arise from individual myometrial cells, with growth influenced by ovarian steroids acting through receptors present on fibroid and myometrial cells [5] . Cytogenetic abnormalities, including translocations and deletions in specific chromosomes, have been identified in a significant proportion of fibroids, contributing to their ~ 6 ~ pathophysiology [5] . Furthermore, the vasculature of fibroids and their response to angiogenic growth factors differentiate them from normal myometrial tissue [5] .…”

Section: Introductionmentioning

confidence: 99%

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The possible association of alpha tocopherol and uterine leiomyoma

Salman,

Rubayae

2024

Int. J. Clin. Obstet. Gynaecol.

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Background: Uterine leiomyomas are noncancerous growths of the reproductive tract that originate from uterine smooth muscle cells. Progesterone and steroid hormones, oestrogen, are regarded as the most crucial elements in the pathophysiology of UFs. Alpha-tocopherol represents the quantum peak of vitamin E's activity. ATs possessing structural determinants, which render them potential ligands for oestrogen receptors (ERs), is crucial with respect to UFs. The purpose of this research was to determine whether serum alpha-tocopherol levels were associated with uterine fibroids. Methods: A case-control investigation was conducted at the Babylon Teaching Hospital specialising in obstetrics and paediatrics from February to November 2019. The present investigation comprises a sample of 100 women. Fifty women diagnosed with uterine fibroids comprise Group A. As a control, fifty women without uterine fibroids comprised Group B. We determined the serum alpha-tocopherol levels of both groups in this investigation. The results were: The levels of serum alpha-tocopherol were compared using the Student's t-test between the two study groups. A statistically significant distinction was observed between the two groups, with cases exhibiting a mean difference of (7.53) μg/mL (11.83±4.50) μg/mL and controls (4.30±1.44) μg/mL (Students'-test = 11.27, d.f. = 98, P-value < 0.001). Conclusion:A strong and statistically significant correlation was observed between elevated levels of AT in the serum and the presence of uterine fibroids. An analysis of serum AT levels revealed no significant correlation between age, BMI, and AT levels.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The possible association of alpha tocopherol and uterine leiomyoma

Salman,

Rubayae

2024

Int. J. Clin. Obstet. Gynaecol.

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“…An endometrial polyp is a focal proliferation of the endometrium, which consists of glandular tissue, stroma, and blood vessels. 1 Endometrial polyps are frequently found during routine preventive transvaginal sonography (TVS) in women without clinical symptoms (Figure 1). 2 Although most endometrial polyps are asymptomatic, for patients with symptoms, the most frequent manifestation is abnormal uterine bleeding.…”

mentioning

confidence: 99%

Diagnostic Accuracy of Transvaginal Sonography in the Detection of Endometrial Polyps

Poliakova¹,

Луценко

2019

Journal of Diagnostic Medical Sonography

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Background: Transvaginal sonography (TVS) is considered a simple and generally accepted method for detecting uterine anomalies. With TVS, the uterus can be clearly visualized, but so far, the diagnostic accuracy of TVS varies across different studies. This retrospective study was devised to evaluate the accuracy of a sonographic diagnosis of endometrial polyps in a Ukrainian hospital. Methods: This was a single-center retrospective study of woman who underwent TVS and had hysteroscopy or dilation and curettage for endometrial pathology. A cohort of 156 women were included in this yearlong study. A comparative analysis was based on the preoperative diagnosis, according to TVS, compared with the postoperative histopathology results. Results: The overall sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of TVS in diagnosing endometrial polyps were 69%, 51%, 73%, 46%, and 63%, respectively. Conclusion: This retrospective study provided data on the lack of accuracy for a sonographic diagnosis of endometrial polyps. This was based on 26% of women whose diagnosis was not confirmed by histology. A false-negative result occurred for 54% of women who had polyps that were not detected at the preoperative stage. These data raise the question of the feasibility of further invasive procedures based on a single TVS study.

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Management dilemma of multiple submucous fibroids in "virgo intacta”

Anyanwu¹,

Alex²,

Sanyang³

et al. 2023

OGIJ

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Nulliparity and advanced age are dependent risk factors of uterine fibroids in the reproductive life of every woman. Fertility-sparing treatment options remain the mainstay of management where there is fertility desire. We present a case report of a 42-year-old Virgo intacta who had abnormal uterine bleeding due to multiple submucous fibroids. An open myomectomy was performed and she made good recovery. Combined oral contraceptive pills were commenced immediately after the operation and continued for 3 months. She had regular periodic bleeding of low volume, flow and duration. Thereafter, subsequent monthly follow-ups were uneventful as a normal regular menstrual cycle was restored. There were management challenges as she was Virgo intacta at 42 years of age. Measures to avoid intrauterine synechiae were limited and combined oral contraceptive was used with good outcome.

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Benign Disease of the Uterus

Cited by 5 publications

References 54 publications

The possible association of alpha tocopherol and uterine leiomyoma

The possible association of alpha tocopherol and uterine leiomyoma

Diagnostic Accuracy of Transvaginal Sonography in the Detection of Endometrial Polyps

Management dilemma of multiple submucous fibroids in "virgo intacta”

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