How neuroactive factors mediates immune responses during pregnancy: An interdisciplinary view

Sun, Jiani; Sun, Jing

doi:10.1016/j.npep.2021.102213

Cited by 4 publications

(2 citation statements)

References 108 publications

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“…The macrophage-secreted inflammatory cytokines are essential for fighting off infections and repairing tissue damage ( 37 ). The immune system relies on cytokines, which are a class of soluble polypeptide mediators secreted by a wide variety of cell types ( 38 ). Produced to mediate or increase the effects of proinflammatory cytokines on peripheral organs, such as IL-6 and IL-1β ( 39 ).…”

Section: Resultsmentioning

confidence: 99%

Anti-inflammatory effects and molecular mechanisms of bioactive small molecule garlic polysaccharide

Shao

Zhang

et al. 2023

Front. Nutr.

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Although garlic polysaccharides have been found to possess anti-inflammatory activities, anti-inflammatory study on small molecule water-soluble garlic polysaccharide (WSGP) is few. In this study, a novel WSGP with a molecular weight of 1853 Da was isolated by DEAE-52 and Sephadex G-100 column and the chemical composition was identified by monosaccharide composition and methylation analysis. Furthermore, the antioxidant effects of WSGP and the potential molecular mechanisms on LPS-induced inflammatory responses in RAW264.7 macrophage cells were investigated. The results showed that WSGP has strong antioxidant activity, such as DPPH, hydroxyl, superoxide anion, ABTS radical scavenging capacity, Fe2+ chelating ability and reducing power. Meanwhile, WSGP could considerably suppress the manufacturing of NO and the mRNA and protein expression degrees of IL-6, TNF-α, and IL-1β in LPS inspired RAW264.7 macrophages WSGP could significantly suppress the production of NO and the mRNA and protein expression levels of IL-1β, IL-6, and TNF-α in LPS stimulated RAW264.7 macrophage cells (p < 0.05). In addition, the phosphorylated IκB-α, p65, and STAT3 proteins were significantly increased in LPS-induced macrophages, while this trend was significantly reversed by WSGP treatment in a concentration-dependent manner (p < 0.05). Consequently, WSGP supplementation might reduce LPS-induced inflammatory responses by suppressing proinflammatory cytokines and NF-κB and STAT3 pathway activation. The finding of this research would give scientific guidelines for the judicious use of small molecular garlic polysaccharide in anti-inflammatory treatments.

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Section: Resultsmentioning

confidence: 99%

Anti-inflammatory effects and molecular mechanisms of bioactive small molecule garlic polysaccharide

Shao

Zhang

et al. 2023

Front. Nutr.

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show abstract

“…The results of this study suggest that a balance of multiple hormonal signals alter neuronal activity via changes in the synapse number in the olfactory cortex and affect olfactory sensing during pregnancy. In addition to the endocrine environment, there are other factors that fluctuate in the maternal body during pregnancy, such as the immune response [ 51 , 52 ] and nutritional status [ 53 , 54 ]. Analyses focusing on the interaction between these factors and endocrine responses are required in a future study.…”

Section: Discussionmentioning

confidence: 99%