How Many High Risk Korean Patients with Osteopenia Could Overlook Treatment Eligibility?

Abstract

Study DesignRetrospective study.PurposeTo determine the prevalence of high risk patient with osteopenia requiring pharmacologic treatment and investigate the difference of 10-year fracture probability whether bone mineral density (BMD) include or not in Korean FRAX model.Overview of LiteratureMany people with the fracture have osteopenia rather than osteoporosis, and BMD alone could be considered as a chance to prevent fracture.MethodsThree hundred sixty-nine patients who was diagnosed as osteopenia were divided into two groups according to age (group 1, under 65 years; group 2, over 65 years), and 10-year fracture probabilities were calculated by FRAX algorithm with and without femur neck T-score.ResultsThe high risk patients of the fracture who had above 3% of 10-year hip fracture probability were 15 cases in group 1 and 121 cases in group 2. In 193 patients of group 1, the mean 10-year fracture probability with BMD was significantly higher than the results without BMD (hip fracture: p=0.04, major osteoporotic fracture: p=0.01). Unlike the results of the group 1, the mean 10-year fracture probability without BMD was significantly higher than the results with BMD in 176 patients of group 2 (hip fracture: p=0.01, major osteoporotic fracture: p=0.01).ConclusionsTotal of 136 cases (36.8%) as a high risk of the fracture with osteopenia could be overlooked treatment eligibility in Korean. The Korean FRAX model without BMD could be effective in predicting fracture risk especially in the individuals who were over 65 years.

FRAX® in Hemodialysis with Osteoporosis- A Registry Study

“…Most of the patients were female (74.7%) and the Body Mass Index (BMI) was [23. 5 When we checked according to the treatment thresholds, 57 of 450 patients (12.7%) had a risk of major osteoporotic fracture ≥20% when calculated with BMD. 33 of 450 patients (7.3%) had a risk of major osteoporotic fracture ≥20% when the BMD is not used to calculate the value.…”

“…With the popular use of FRAX ® , there is still a debate related to this tool without BMD information although the inclusion of BMD is optional [5,6]. However, another document found that including BMD in FRAX ® may greatly underestimate the risk [7].…”