How Many Contralateral Papillary Thyroid Carcinomas Can Be Missed?

Lee, Kwan Ju; Cho, Yunjung; Kim, Jeong Goo; Lee, Dong Hoon

doi:10.1007/s00268-013-1913-0

Cited by 38 publications

(44 citation statements)

References 22 publications

(26 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[1,2,8–12] This rate varies across reports, which may be due to population differences and small sample sizes. In the analysis of consecutive cases in our institute from 1999 to 2008, multifocal PTC was observed in 28.6% of cases.…”

Section: Discussionmentioning

confidence: 99%

“…[6,7] Studies have shown that unilateral multifocality of the primary tumor and the presence of a coexistent benign nodule in the contralateral lobe by preoperative evaluation were independent predictive factors for occult contralateral PTC. [8,9,11,12] Wu et al [11] performed total thyroidectomy in 347 patients with unilateral papillary microcarcinoma combined with coexistent nodules in the contralateral lobe, and occult contralateral PTC was observed in 28.9%. Multivariate analysis showed that unilateral multifocality, presence of coexistent benign nodules in the contralateral lobe, and maximum tumor diameter greater than 5 mm were independent predictive factors of contralateral occult carcinoma, total thyroidectomy was thus suggested for patients with unilateral papillary microcarcinoma if they had any of the following factors: maximum tumor diameter greater than 5 mm, unilateral multifocality, or the presence of coexistent nodules in the contralateral lobe.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Long-term outcome of thyroid lobectomy for unilateral multifocal papillary carcinoma

Huang

Liu

et al. 2017

Medicine

View full text Add to dashboard Cite

The National Comprehensive Cancer Network (NCCN) guidelines recommend completion thyroidectomy for patients with multifocal papillary thyroid carcinoma (PTC) diagnosed by paraffin pathology after lobectomy. However, studies for the influence of surgical range on prognosis of unilateral multifocal carcinoma are scarce. We analyzed the clinicopathological characteristics and long-term outcomes of patients with unilateral multifocal PTC to identify risk factors for recurrence and disease-related death.The clinical and pathological data of 123 cases with multifocal lesions in the unilateral thyroid lobe were retrospectively collected, including sex, age, stage, surgical range, histopathology characteristics, and follow-up data. The prognostic factors were analyzed by means of the Kaplan–Meier method.The recurrence in the contralateral residual thyroid was observed in 6 cases. The 10-year cumulative recurrence rate of the remnant thyroid was 7.0%. Extrathyroidal extension (ETE) was a significant prognostic factor, with χ2 equal to 4.043 and a P value of .044. One patient died from progression of pulmonary metastasis during the follow-up. The 10-year disease-specific survival rate was 96% and 14 cases experienced recurrences and underwent a second surgery (11.4%), and thus the 10-year recurrence-free survival rate was 83.2%. Multivariate analysis showed that the pathologic tumor (pT) stage was an independent prognostic factor for the recurrence-free survival rate (P <.0001, hazard ratio 2.871, 95% confidence interval 1.783–4.624).ETE is a significant prognostic factor for the recurrence of the remnant thyroid and pT stage is an independent prognostic factor for tumor recurrence-free survival. Lobectomy (with isthmectomy) is effective for most patients with unilateral multifocal PTC.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Long-term outcome of thyroid lobectomy for unilateral multifocal papillary carcinoma

Huang

Liu

et al. 2017

Medicine

View full text Add to dashboard Cite

show abstract

“…It should be noted here that no cut-off value of tumor size was determined in our study. Lee et al [10] also reported that bilaterality was found more frequently when the tumor was large. In another study, the presence of three or more tumor foci or bilaterality of tumor tended to be present with larger tumors [11].…”

Section: Discussionmentioning

confidence: 93%

The Clinicopathological Factors Associated with Multicentricity in Papillary Thyroid Cancer

Kılıç¹

2016

Ann Clin Anal Med

View full text Add to dashboard Cite

Anahtar KelimelerBilateralite; Multisentrisite; Papiller Tiroid Kanser Abstract Aim: Multicentricity is a frequent feature of papillary thyroid cancer, and is generally associated with advanced stage, increased risk of regional and distant metastasis. In this study, we aimed to determine the associated clinicopathological factors on multicentricity in papillary thyroid cancer. Material and Method: One hundred and thirty patients with papillary thyroid cancer were included in this retrospective study. The affecting clinical and histopathological factors on multicentricity were investigated. Results: Total thyroidectomy with or without central/lateral neck dissection was performed in 130 patients (101, 77.7% were female and 29, 22.3% were male) with a mean age of 43.03 years. The diagnosis of papillary thyroid cancer was confirmed by final histopathology in all cases. Multicentricity and bilaterality were detected in 54 (41.5%) and 16 (12.3%) patients, respectively. Tumor size (p= 0.046) and perineural invasion (p= 0.020) were significantly different between the patients with multicentric cancer and those with solitary cancer. Discussion: According to the findings obtained from this study, tumor size and perineural invasion were the affecting factors on multicentricity in papillary thyroid cancer. However, large-scale, multicenter clinical and genetic studies are needed to clearly determine the affecting factors on multicentricity of these cancers.

show abstract

“…[39], общая частота билатерального поражения при папиллярном раке составляет 29,8%: у пациентов с размером опухоли ≥1 см 36,8%, у пациентов с микрокарциномами 25,7%. В данном исследовании диагноз билатераль-ного поражения был основан на гистологическом исследовании у 5,5% пациентов.…”

Section: мультифокальные микрокарциномыunclassified

“…По данным различных авторов, мультифокаль-ность обнаруживается в 15-35,6% случаев микрокар-цином и является важным прогностическим факто-ром персистенции [5,6,10,19,[38][39][40]. Учитывая, что при мультифокальности высока вероятность билате-рального поражения (25-27% случаев), при микро-карциномах рекомендуют проведение тотальной ти-реоидэктомии.…”

Section: мультифокальные микрокарциномыunclassified