How Low Should You Go: Novel Device for Nail Trephination

Ciocon, David H.; Gowrishankar, Thiruvallur R.; Herndon, Terry O.; Kimball, Alexa B.

doi:10.1111/j.1524-4725.2006.32168.x

Cited by 5 publications

(2 citation statements)

References 12 publications

(20 reference statements)

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“…The attainment of effective drug concentrations in the nail bed, therefore, remains an elusive goal and has stimulated a number of attempts to disrupt nail structure so as to enhance the rate and extent of topical delivery [5]. Chemical enhancers, for example thiols, sulphites and hydrogen peroxide, have been used to destabilise keratin conformation, while physical techniques investigated include iontophoresis [6], low-frequency ultrasound (sonophoresis) [7], acid etching [8] and microporation [9,10].…”

Section: Introductionmentioning

confidence: 99%

Precise laser poration to control drug delivery into and through human nail

Vanstone

Cordery

Stone

et al. 2017

Journal of Controlled Release

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Drug treatment of diseases of the human nail remains a difficult challenge; topical therapy, in particular, is limited by very poor transport of active agents across the nail itself. The objective of this research was to examine the potential of controlled, and fibre-optic delivered, femtosecond laser light pulses to provide new pathways and opportunities for drug access to targets within and beneath the nail plate. Optical, confocal fluorescence and scanning electron microscopies demonstrated partial and complete laser poration of human nail samples, with the energy per pore and the exposure duration being the key modulating parameters that determined the extent of ablation achieved. Parallel measurements of the penetration of a model drug across laser-treated nails showed that complete poration resulted in essentially complete circumvention of the diffusion barrier, an array of 100 pores in 0.2cm area of nail permitting a 10-fold increase in initial drug uptake. Partial ablation of the nail created pores that extended to a range of depths; the nail material adjacent to the ablated area was rendered porous in appearance presumably due to local thermal perturbation of the nail structure. These openings offer, as a result, potential sites in which topical drug formulations might be sequestered post-poration and from which slow, sustained delivery of the active agent into and through the nail may be envisaged.

show abstract

Section: Introductionmentioning

confidence: 99%

Precise laser poration to control drug delivery into and through human nail

Vanstone

Cordery

Stone

et al. 2017

Journal of Controlled Release

View full text Add to dashboard Cite

show abstract

“…47 FDA tarafından onaylı olan bu cihazın herhangi bir acı/ağrı oluşturmaması nedeni ile gönüllü bireyler tarafından iyi tolere edildiği bildirilmiştir. 48 Bu alet kullanılarak yapılan bir çalışmada, terbinafin krem, mikropor oluşturulmuş tırnak plağına uygulanmış ve etken maddenin penetrasyonunun arttığı gösterilmiştir. 49 Tırnak altında oluşan hematomu boşaltmak için geliştirilmiş bu cihazın, etken maddelerin tırnak plağına penetrasyonunu artırmak amacıyla kullanılmasındaki en önemli sıkıntının, tırnakta çok sayıda delik açılması zorunluluğu olduğu bildirilmiştir.…”

Section: Tirnak Plağinin Mi̇kroporasyonuunclassified