How it appears: electron microscopic evaluation of internal limiting membrane specimens obtained during brilliant blue G assisted macular hole surgery

Schumann, Ricarda G.; Remy, Matthias; Grueterich, Martin; Gandorfer, Arnd; Haritoglou, Christos

doi:10.1136/bjo.2007.128421

Cited by 14 publications

(15 citation statements)

References 8 publications

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“…48,50 Interestingly, the analysis of ILM collected after BBG use did not show any morphologic alterations, neither in the retina nor in the vitreous of the ILM samples, in contrast with the abnormalities observed with ICG. 17,51,52 A recent electron microscopy study of the internal limiting membrane confirmed the benefit of using TB, BBG, and bromophenol blue when compared with ICG. 53 The main strength of this study is that our experimental design is close to physiological and surgical conditions.…”

Section: Discussionmentioning

confidence: 91%

“…11,12 More recently, reports have appeared on the efficacy of BBG in staining the ILM; the results from animal studies [13][14][15] and the subsequent first evaluations in humans underlined its potential. 16,17 However, safety studies remain necessary to confirm these results. The purpose of this study was to compare the potential toxicity of ICG, TB, TA, and BBG after intravitreal injection in rats.…”

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confidence: 99%

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Functional and Structural Effect of Intravitreal Indocyanine Green, Triamcinolone Acetonide, Trypan Blue, and Brilliant Blue G on Rat Retina

Creuzot‐Garcher¹,

Acar²,

Passemard³

et al. 2010

Retina

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Section: Discussionmentioning

confidence: 91%

mentioning

confidence: 99%

Functional and Structural Effect of Intravitreal Indocyanine Green, Triamcinolone Acetonide, Trypan Blue, and Brilliant Blue G on Rat Retina

Creuzot‐Garcher¹,

Acar²,

Passemard³

et al. 2010

Retina

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“…In contrast, BBG stains for ILM selectively, with no known adverse effects at present. [53][54][55] '…”

Section: Recurrence Of Erm and Foveal Contour After Ilm Peeling Versumentioning

confidence: 99%

Internal Limiting Membrane Peeling During Idiopathic Epiretinal Membrane Removal

Roh¹,

Eliott²

2015

International Ophthalmology Clinics

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Idiopathic epiretinal membrane (ERM) is characterized by the growth of fibrocellular tissue on the internal limiting membrane (ILM). An ERM can range from a subtle cellophane-like film that does not cause any visual disturbance to a significant, multilayered, contractile membrane with folds in the underlying and adjacent retina, causing metamorphopsia and a decline in visual acuity. Although the exact pathogenesis of ERM formation is unclear, it is known to be associated with posterior vitreous detachment 1 leading to hypertrophy of glial (Muller) cell processes and the accumulation of extracellular matrix components on the ILM. The ILM is the basement membrane of the Muller cells. 2,3 ' ERM Surgery Pars Plana VitrectomyAlthough there are rare cases in which an ERM spontanously separates from the retina and induces regression of the macular distortion, 4,5 in the great majority of cases it remains stable or progresses slowly. Progression of an ERM often results in underlying retinal changes with thickening and/or folds that can lead to a decline in visual acuity. Standard pars plana vitrectomy to remove the vitreous gel and ERM has traditionally been the standard of therapy for visually significant ERM and usually results in significant regression of the retinal thickening and/or folds. However, reports show that the

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“…We read with interest the article by Schumann et al ,1 who have reported the ultrastructural analyses of internal limiting membrane (ILM) specimens after staining with new dye Brilliant Blue G (BBG). In their study, morphological analyses failed to reveal any adverse effects possibly related to BBG.…”

mentioning

confidence: 99%

Subretinal Brilliant Blue G migration during internal limiting membrane peeling

Maia

Farah

Rodrigues

et al. 2009

British Journal of Ophthalmology

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How it appears: electron microscopic evaluation of internal limiting membrane specimens obtained during brilliant blue G assisted macular hole surgery

Cited by 14 publications

References 8 publications

Functional and Structural Effect of Intravitreal Indocyanine Green, Triamcinolone Acetonide, Trypan Blue, and Brilliant Blue G on Rat Retina

Functional and Structural Effect of Intravitreal Indocyanine Green, Triamcinolone Acetonide, Trypan Blue, and Brilliant Blue G on Rat Retina

Internal Limiting Membrane Peeling During Idiopathic Epiretinal Membrane Removal

Subretinal Brilliant Blue G migration during internal limiting membrane peeling

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