How is cognition in subthalamic nucleus deep brain stimulation Parkinson’s disease patients?

Barbosa, Eduarda Naidel Barboza e; Fichman, Helenice Charchat

doi:10.1590/1980-57642018dn13-040002

Cited by 7 publications

(1 citation statement)

References 36 publications

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“… 16 44 Deep brain stimulation has been reported as a procedure that can improve both motor symptoms and cognitive aspects. 16 45 However, the P300 elicited during DBS-on and DBS-off conditions did not show statistically significant changes in latency or amplitude. This finding correlates with the fact that the P300 potential is produced by a series of generators that are not affected by subthalamic nuclei projections.…”

Section: Discussionmentioning

confidence: 81%

The Application of P300-Long-Latency Auditory-Evoked Potential in Parkinson Disease

Ferrazoli

Donadon

Rezende

et al. 2021

Int Arch Otorhinolaryngol

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Introduction Parkinson disease (PD) is a degenerative and progressive neurological disorder characterized by resting tremor, stiffness, bradykinesia, and postural instability. Despite the motor symptoms, PD patients also consistently show cognitive impairment or executive dysfunction. The auditory event-related potential P300 has been described as the best indicator of mental function, being highly dependent on cognitive skills, including attention and discrimination. Objective To review the literature on the application and findings of P300 as an indicator of PD. Data Analysis The samples ranged from 7 to 166 individuals. Young adult and elderly male patients composed most study samples. The Mini-Mental State Examination test, the Unified Parkinson Disease Rating Scale, and the Hoehn and Yahr Scale were used to assess neurological and cognitive function. In terms of testing hearing function, few studies have focused on parameters other than the P300. The factors we focused on were how the P300 was modified by cognitive effects, its correlation with different PD scales, the effect of performing dual tasks, the effect of fatigue, and the influence of drug treatments. Conclusion The use of the P300 appears to be an effective assessment tool in patients with PD. This event-related potential seems to correlate well with other neurocognitive tests that measure key features of the disease.

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