The Application of P300-Long-Latency Auditory-Evoked Potential in Parkinson Disease

Ferrazoli, Natalia; Donadon, Caroline; Rezende, Adriano; Skarżyński, Henryk; Sanfins, Milaine Dominici

doi:10.1055/s-0040-1722250

Cited by 11 publications

(6 citation statements)

References 41 publications

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“…It is also worth noting that the P1 and N1 components respond to spectral characteristics of a sound stimulus [ 46 ]. Finally, changes in the P300 component can be related to cognitive functions, such as decision-making, attention, discrimination, recognition, integration, focus, and memory [ 41 – 43 ]. All of this corroborates findings that AT tends to reduce the latency of the P300 component [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Students Aged Between 8 and 12 years

et al. 2023

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Background Learning to read and write depends on the effective functioning of various sensory systems, including the auditory system. Auditory information processing involves behavioral and electrophysiological processes. Electrophysiological procedures are used to investigate activity in the auditory pathway in response to sound stimuli, and the associated cortical activity in discrimination, integration, and attention. The study evaluated electrophysiological testing for an auditory processing disorder and reading performance in 54 school students aged between 8 and 12 years. Material/Methods The study involved 54 public school students aged between 8 and 12 years, who were divided into a study group and control group. All children underwent basic audiological assessment, rating of reading and writing ability, non-verbal intelligence, auditory brainstem response, long-latency auditory-evoked potentials (LLAEP), frequency following responses (FFR), and auditory training (AT). Results The basic audiological evaluation showed a statistically significant difference between groups only for the frequency of 6 kHz. The LLAEP response had a statistically significant difference between groups for N1 latency, P300 latency, and amplitude. Finally, there was a statistically significant difference between pre-AT and post-AT to LLAEP for latencies of P2, N2, and P300 and amplitudes of N2 and P300, and to FFR for latency of wave C. Conclusions This study showed that electrophysiological tests are sensitive tools for identifying deficits in the auditory pathway. Moreover, latency measures can detect improvements from an auditory training program. In this way, an auditory intervention program might help children with reading and writing difficulties.

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Section: Discussionmentioning

confidence: 99%

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Students Aged Between 8 and 12 years

et al. 2023

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“…When analyzing the effectiveness of auditory training through the P300, the authors found reduced latency and increased P300 amplitude after the intervention, results that are consistent with the findings of the current study. This potential has been described as the best indicator of auditory function, being highly dependent on cognitive skills, including attention and memory (30) . Therefore, it is believed that there was no statistically significant difference in latency and amplitude of the cognitive potential -P300 in this study, due to the sample n and the great variability of the sample.…”

Section: Discussionmentioning

confidence: 99%

Cognitive auditory training in subjects after COVID-19: an analysis of the effects of the intervention in adults

Soares,

Malavolta,

Sanfins

et al. 2023

Audiol., Commun. Res.

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Purpose To analyze the effectiveness of a therapeutic intervention plan through an existing cognitive auditory training program, adapted for adults, after one year of COVID-19 infection. Methods 13 subjects, between 18 and 59 years old, four males and nine females participated in the study. All underwent anamnesis, visual inspection of the external acoustic meatus, pure tone audiometry, speech audiometry and acoustic immitance measurements as selection procedures. For the research, the following procedures were carried out in the evaluation and reassessment: evaluation of central auditory processing, brief neuropsychological evaluation - NEUPSILIN, Speech, Spatial and Qualities of Hearing Scale and the Cognitive Potential - P300 with speech stimulus. Cognitive auditory training was carried out in six consecutive sessions, in an open field, lasting approximately 50 minutes. In all analyses, a significance level of 5% (p≤0.05) was considered. Results When comparing the variables between the periods, pre and post intervention, there was a statistically significant difference in the Dichotic Digit Test (p = 0.009), in the Frequency Pattern Test (p = 0.020) and in Speech, Spatial and Qualities of Hearing Scale (p = 0.001). And a tendency to significance (p < 0.10) in the Gap in Noise test and Total Attention. Conclusion Cognitive auditory training proved to be an effective therapeutic strategy for the treatment of adults with speech comprehension and cognition complaints after COVID-19 infection.

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“…Studies have found abnormal ERPs in patients with PDD. The study reported that P3 and N2 latencies in patients with dementia were significantly longer than normal controls, while patients with PD without dementia had only an extended P3 latency [17] . The study found that PD with dementia was significantly longer in P3 latency compared with control groups.…”

Section: Groupmentioning

confidence: 92%

Clinical Observation of Sodium Oligomannate Capsules in the Treatment of Cognitive Dysfunction in Parkinson's Disease

Yin,

Hu,

Xie

et al. 2023

IJPS

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To observe the effect of sodium oligomannate capsules on cognitive dysfunction in Parkinson's disease. 120 patients with cognitive dysfunction were randomly divided into, 60 in treatment and 60 in control group and given sodium oligomannate capsules dose of 5 mg/d, 450 mg/d respectively and compared cognitive function scores (mini-mental state examination, Montreal cognitive assessment). After treatment, serotonin, dopamine, norepinephrine levels and event-related potential are measured. Compared with pre-treatment, the Montreal cognitive assessment and mini-mental state examination scores were significantly different after treatment (both p<0.05), and Montreal cognitive assessment and mini-mental state examination scores were significantly higher after treatment (both p<0.05). Compared to the control group, Montreal cognitive assessment and mini-mental state examination scores before treatment (both p>0.05), and Montreal cognitive assessment and mini-mental state examination scores were significantly increased after treatment (both p<0.01). Before treatment, serum serotonin, dopamine and norepinephrine levels were compared (p>0.05), and serotonin, dopamine and norepinephrine were higher than the control group (p<0.01). The latency period of N2 and P3 was significantly prolonged, and the N2 and P3 incubation periods were significantly reduced, with significant differences (p<0.01). Sodium oligomannate capsules can improve the cognitive function of Parkinson's disease patients by regulating neurotransmitter levels, reducing N2 and P3 latency, improving short and delayed memory and directional force.

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The Application of P300-Long-Latency Auditory-Evoked Potential in Parkinson Disease

Cited by 11 publications

References 41 publications

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Students Aged Between 8 and 12 years

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Students Aged Between 8 and 12 years

Cognitive auditory training in subjects after COVID-19: an analysis of the effects of the intervention in adults

Clinical Observation of Sodium Oligomannate Capsules in the Treatment of Cognitive Dysfunction in Parkinson's Disease

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