How in the 20th century physicists, chemists and biologists answered the question: what is life?

Реутов, В. П.; Schechter, Alan N.

doi:10.3367/ufne.0180.201004d.0393

Cited by 19 publications

(6 citation statements)

References 61 publications

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“…It also answers the question of why development is carried out in a spiral, and why spirals are one of the main structural elements in DNA, proteins, in nerve fibers (myelin sheaths), glial cells (glial wraps in the central nervous system), etc. This principle also explains the nature of the cyclical / periodic pattern in the functioning of regulatory systems at almost all structural and functional levels in living organisms [72]. In addition, this principle and the consequences arising from it are in good agreement with other concepts and theories of scientists.…”

Section: Causes and Effects Of Universal Principlessupporting

confidence: 74%

“…After 20 years, the nitrite reductase activity of hemoglobin in the deoxy-form was confirmed in the works of researchers from the United States [71]. Subsequently, this concept has repeatedly found its development and application for various normal and pathological processes [28,[37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52]72].…”

Section: Scheme Of Nitric Oxide (No) and Superoxide Anion Radical (mentioning

confidence: 99%

“…If such a reaction occurs, then we can say that the hydrogen sulfide cycle exists not only in the whole organism of mammals, but also in their cells. The cycles presented above are, from our point of view, a manifestation of the global principle of cyclicity [54][55][56]72]. At the same time, the geochemical cycles of nitrogen, carbon, sulfur and water are known as the natural cycles.…”

Section: Scheme Of Hydrogen Sulfur / Sulfur Dioxide Cycle (H 2 S / So...mentioning

confidence: 99%

“…Over the past decades, we have suggested that the cyclic organization NO and • O 2 in cells and in the whole organism may be a consequence of the existence of such a principle, the universality of which is comparable to the principle of the atomic structure of matter [54][55][56]72,74]. This principle extends its influence to almost all structural and functional levels in animate and inanimate nature, subordinates the behavior of living subjects and inanimate objects, and, sets the rules for the functioning of all regulatory systems that contain elements of negative and positive feedback.…”

Section: Causes and Effects Of Universal Principlesmentioning

confidence: 99%

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Evolutionary aspects of a typical pathological process

2023

Open J Clin Med Case Rep

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Section: Causes and Effects Of Universal Principlessupporting

confidence: 74%

Section: Scheme Of Nitric Oxide (No) and Superoxide Anion Radical (mentioning

confidence: 99%

Section: Scheme Of Hydrogen Sulfur / Sulfur Dioxide Cycle (H 2 S / So...mentioning

confidence: 99%

Section: Causes and Effects Of Universal Principlesmentioning

confidence: 99%

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Evolutionary aspects of a typical pathological process

2023

Open J Clin Med Case Rep

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“…weight and biological activation of the inflammatory reaction; • Treat diabetes, primarily as abnormalities of metabolism LCD and secondarily as pathological metabolic GLU; • To understand the functional, clinical and diagnostic value of two phylogenetically different parts of the arterial bed, the role of blood pressure as a biological response that is involved in the implementation of many biological functions; understand the biological basis of normalization so often high blood pressure [47].…”

Section: Formation Of Biological Functions On the Steps Of Phylogeny;mentioning

confidence: 99%

Pathology: A Review

Iyer¹

2014

Biochem Physiol

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A characteristic feature of the beginning of the XXI century medicine is that the achievement of bio-medical, diagnostic disciplines significantly outperforms progress to the clinic for the treatment of the most common diseases in the population. It atherosclerosis, diabetes, essential hypertension, and obesity, figuratively these diseases we call "metabolic pandemic". The frequency of these diseases in the populations of developed countries continues to increase, and all the efforts of clinicians and pharmaceutical companies do not produce the desired result, with the etiological factors are beginning to be better understood, which, however, cannot be said with regard to the pathogenesis. If the high expectations for the clinical use of genetics and genomics, gene polymorphisms have not justified, the possibility of metabolomics and proteomics are so great that their use in the diagnosis has not yet begun. We are not prepared to give the diagnostic interpretation of biochemical data in order to offer us the modern methods of physical chemistry, which at the same time, the concentration of dozens of proteins, substrates and metabolites. We cannot use the results of modern methods of diagnosis; we have no theoretical base -the modern theory of disease. It formed a large distance (gap) between the possibilities of the use of modern methods of research and its real application in the diagnosis of metabolic pandemics.Keywords: Pathogenesis; Diseases; Pandemic; Metabolic Phylogenetic Theory of DiseaseImprovement of diagnostic techniques including sequencing and gene expression, proteomics, metabolomics is the result of the development of physical chemistry, biochemistry, and analytical instrumentation in the last decade. Improvements in medical science and practice, the development trend of the general biology, physical chemistry, and diagnostic disciplines require the formation of a new theory of disease, the theory of the XXI century [1]. It is desirable that such a theory has incorporated: a) the provisions of the humoral and cellular theory of disease XIX century, and b) the achievement of pathology in the XX century c) the provision of physical chemistry, and d) new methodological approaches of general biology. It is important to view the system as a biological medicine, "historical" science and analysis of the development in the phylogeny of species Homo sapiens [2,3]. A new theory of disease should clearly formulate the provisions of Basic Medicine and based on it, using a systematic approach to continue further development of medical science. We propose to understand the commonalities and differences in the etiology and pathogenesis of so prevalent in populations of XX and XXI century diseases that we call "metabolic pandemic." Naturally, in the XIX century theories about the "metabolic pandemic" do not say anything. In the phylogenetic theory of disease we propose to consider what is happening in vivo in terms of biological functions and biological reactions."Any biological research is justified only...

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