Pathology: A Review

Abstract

A characteristic feature of the beginning of the XXI century medicine is that the achievement of bio-medical, diagnostic disciplines significantly outperforms progress to the clinic for the treatment of the most common diseases in the population. It atherosclerosis, diabetes, essential hypertension, and obesity, figuratively these diseases we call "metabolic pandemic". The frequency of these diseases in the populations of developed countries continues to increase, and all the efforts of clinicians and pharmaceutical companies do not produce the desired result, with the etiological factors are beginning to be better understood, which, however, cannot be said with regard to the pathogenesis. If the high expectations for the clinical use of genetics and genomics, gene polymorphisms have not justified, the possibility of metabolomics and proteomics are so great that their use in the diagnosis has not yet begun. We are not prepared to give the diagnostic interpretation of biochemical data in order to offer us the modern methods of physical chemistry, which at the same time, the concentration of dozens of proteins, substrates and metabolites. We cannot use the results of modern methods of diagnosis; we have no theoretical base -the modern theory of disease. It formed a large distance (gap) between the possibilities of the use of modern methods of research and its real application in the diagnosis of metabolic pandemics.Keywords: Pathogenesis; Diseases; Pandemic; Metabolic Phylogenetic Theory of DiseaseImprovement of diagnostic techniques including sequencing and gene expression, proteomics, metabolomics is the result of the development of physical chemistry, biochemistry, and analytical instrumentation in the last decade. Improvements in medical science and practice, the development trend of the general biology, physical chemistry, and diagnostic disciplines require the formation of a new theory of disease, the theory of the XXI century [1]. It is desirable that such a theory has incorporated: a) the provisions of the humoral and cellular theory of disease XIX century, and b) the achievement of pathology in the XX century c) the provision of physical chemistry, and d) new methodological approaches of general biology. It is important to view the system as a biological medicine, "historical" science and analysis of the development in the phylogeny of species Homo sapiens [2,3]. A new theory of disease should clearly formulate the provisions of Basic Medicine and based on it, using a systematic approach to continue further development of medical science. We propose to understand the commonalities and differences in the etiology and pathogenesis of so prevalent in populations of XX and XXI century diseases that we call "metabolic pandemic." Naturally, in the XIX century theories about the "metabolic pandemic" do not say anything. In the phylogenetic theory of disease we propose to consider what is happening in vivo in terms of biological functions and biological reactions."Any biological research is justified only...