How Has the Introduction of New Bearing Surfaces Altered the Biological Reactions to Byproducts of Wear and Modularity?

Wooley, Paul H.

doi:10.1007/s11999-014-3725-4

Cited by 11 publications

(9 citation statements)

References 82 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, the adopted Ti particle-induced murine calvarial osteolysis model cannot perfectly simulate ALP in patient. From metal and UHMWPE (ultrahigh-molecular-weight polyethylene) to ceramic and PEEK (polyether-ether-ketone), the myriad of particles worn from interfaces of any kind could contributed the periprosthetic osteolysis of varying severity 39 . With structure of thin cortical bone and little stress bearing, murine calvarium only serve as a defective analogue of ALP in hip or knee joint of human 9 .…”

Section: Discussionmentioning

confidence: 99%

Cimifugin Suppresses NF-κB Signaling to Prevent Osteoclastogenesis and Periprosthetic Osteolysis

Duan

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: Aseptic loosening of prosthesis (ALP) is one of the most common long-term complication of knee and hip arthroplasty. Wear paticle-induced osteoclastogenesis and subsequent periprosthetic osteolysis accounts for the morbidity of ALP. Here, we investigate cimifugin (CIM), a natural extract from Cimicifuga Racemosa and Saposhnikovia Divaricata, as a bone protective drug in treatment of ALP.Method: First, we deployed cell viability and osteoclast formation assays to detect the effect of noncytotoxic CIM on osteoclast differentiation in vitro. Bone slice resorption evaluation and F-actin ring immunofluorescence assays were adopted to measure bone-resorbing function affected by CIM. Then, we introduce quantitative real-time polymerase chain reaction (qRT-PCR) analysis to further identify the repressed osteoclastogenesis by CIM in gene expression level. To reveal underlying mechanism of findings above, we used Western blotting and luciferase reporter gene assay to determine the regulation manner of CIM in NF-κB and MAPKs signaling pathways. Moreover, Ti particle-induced murine calvarial osteolysis model and following histomorphometric analysis via micro-CT and immunohistochemical staining were used to demonstrate the effect of CIM on periprosthetic osteolysis in vivo. Result: CIM administration dose-dependently inhibited both bone marrow-derived macrophages (BMMs) and RAW264.7 cells derived osteoclastogenesis and bone resorption pit formation in vitro, which further supported by reduced expression of F-actin and osteoclast specific genes. According to the Western blotting analysis, inhibition of IkBa phosphorylation in NF-κB signaling pathway, not the phosphorylation of MAPKs, was detected as the suppressive effect of CIM on osteoclastogenesis. In vivo animal experiment demonstrated that CIM alleviated Ti particle-induced bone erosion and osteoclast accumulation in murine calvaria. Conclusion: The current study for the first time proved that CIM could dose-dependently inhibit RANKL-induced osetoclastogenesis via suppressing NF-κB signaling pathway in vitro and prevent periprosthetic osteolysis in vivo. These findings suggest the potential therapeutic use of CIM in ALP.

show abstract

Section: Discussionmentioning

confidence: 99%

Cimifugin Suppresses NF-κB Signaling to Prevent Osteoclastogenesis and Periprosthetic Osteolysis

Duan

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…19–21 Prosthetic wear is defined as the loss of prosthetic material from the articulating interface of the joint due to abrasion, corrosion, and fatigue. 22,23 Wear on the implant results in particulate matter depositing in the periprosthetic space. This debris triggers an inflammatory response leading to periprosthetic osteolysis.…”

Section: Osteolysismentioning

confidence: 99%

“…Debris accumulates, and increases a cell-mediated immune response leading to osteolysis. 22 The inflammatory reaction leading to osteolysis occurs if the debris is biologically stimulating immune cells to release factors affecting the structural cells. In the host-defense mechanism, there is a trigger of both pro-inflammatory and pro-protective and pro-regenerative pathways due to debris from the prosthetics.…”

Section: Macrophagesmentioning

confidence: 99%

See 1 more Smart Citation

Immunobiology of periprosthetic inflammation and pain following ultra-high-molecular-weight-polyethylene wear debris in the lumbar spine

Werner

Rosenberg

Keeley

et al. 2018

Expert Review of Clinical Immunology

View full text Add to dashboard Cite

Wear debris-induced osteolysis is a common cause of arthroplasty failure in several joints including the knee, hip and intervertebral disc. Debris from the prosthesis can trigger an inflammatory response that leads to aseptic loosening and prosthesis failure. In the spine, periprosthetic pain also occurs following accumulation of wear debris through neovascularization of the disc. The role of the immune system in the pathobiology of periprosthetic osteolysis of joint replacements is debatable. Areas covered: We discussed the stimulation of pro-inflammatory and pro-protective and pro-regenerative pathways due to debris from the prosthetics. The balance between the two pathways may determine the outcome results. Also, the role of cytokines and immune cells in periprosthetic inflammation in the etiology of osteolysis is critically reviewed. Expert commentary: Therapies targeting the inflammatory process associated with ultra-high-molecular-weight polyethylene wear debris could reduce implant failure. Additionally, therapies targeting neovascularization of discs following arthroplasty could mitigate periprosthetic pain.

show abstract

“…According to the data of the Norwegian Arthroplasty Registry, aseptic loosening accounts for 37% of revisions [3]. Some publications indicate an even higher percentage of revision operations due to aseptic loosening -close to 63% [4,5]. Revisions are clearly more often caused by loosening of the acetabular cup rather than the femoral stem [3].…”

Section: Introductionmentioning

confidence: 99%

Extensive type IIIB bone loss of the acetabulum and suitability of 3D printings during planning

Filip¹,

Snela²,

Przeszłowski³

et al. 2021

J Pre Clin Clin Res.

View full text Add to dashboard Cite

Introduction. Despite the advances made in medicine, arthroplasty performed in young patients is still associated with an increased risk of complications. Massive destruction of the acetabular ring is a challenge, requires careful planning, and the use of various surgical techniques and implants. Case Report. The case is presented of a young woman with a Paprosky type IIIB defect of the acetabular rin who underwent a revision total hip arthroplasty. During planning, 3D printed bone models were used because the choice of surgical technique was not obvious. The 3D prints, together with the radiological diagnostics performed, provided a real picture of the problem, and a better understanding of the pathoanatomy. Conclusions. Multiple, unpunished trialing on printed models by using different trial implants make it possible to test the feasibility and practice the techniques. It may prevent making the mistake of choosing wrong the surgical technique. Additionally, the models give better visualization of the patient's anatomy during the surgery lifetime.

show abstract

How Has the Introduction of New Bearing Surfaces Altered the Biological Reactions to Byproducts of Wear and Modularity?

Cited by 11 publications

References 82 publications

Cimifugin Suppresses NF-κB Signaling to Prevent Osteoclastogenesis and Periprosthetic Osteolysis

Cimifugin Suppresses NF-κB Signaling to Prevent Osteoclastogenesis and Periprosthetic Osteolysis

Immunobiology of periprosthetic inflammation and pain following ultra-high-molecular-weight-polyethylene wear debris in the lumbar spine

Extensive type IIIB bone loss of the acetabulum and suitability of 3D printings during planning

Contact Info

Product

Resources

About