How genes and environment interact to shape risk and resilience to stress-related psychiatric disorders

Brain-Based Biotypes of Psychiatric Vulnerability in the Acute Aftermath of Trauma

“…2021.20101526 The diathesis-stress model of psychopathology has remained one of the most well-supported theories addressing the causes of mental disorders. In combination with predisposing factors, antecedent stressors increase risk for the onset and recurrence of depression (1), schizophrenia (2), insomnia (3), and posttraumatic stress disorder (PTSD) (4). However, stress and its severity or chronicity alone cannot account for the wide variety of different types of mental health outcomes that can follow major stressful life events (5), theoretically driven by existing individual differences (6).…”