Novel treatment targets for COVID-19: Contribution from molecular psychiatry

Schmidt, Ulrike; Rein, Theo

doi:10.1080/15622975.2020.1779344

Cited by 2 publications

(1 citation statement)

References 69 publications

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“…Currently, there is not any acceptable antiviral drug to treat SARS-CoV-2 infections. Hence, preventive and supportive cares of complications are essential strategies to minimize the harms [11,12]. Suggested strategies for the treatment of SARS-CoV-2 might be divided into four different categories: SARS-CoV-2 RNA synthesis prevention, through vital proteins and enzymes inhibition, virus-cell receptor binding impedition or virus selfassembly suppletion, the host's immunity stimulation by producing virulence factors, and virus entry blockage into host cells by acting on the host's enzymes or through cellular entry receptors [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Possible Therapeutic Targets from Derivatives of Natural Marine Products Based on PI3K/AKT Dependent Inhibitors in Viral Infection COVID-19

Aleebrahim-Dehkordi

Koochaki

Samami

et al. 2022

Cell Physiol Biochem

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Natural resources have long played a prominent part in conventional treatments as a parental source due to their multifaceted functions and lesser side effects. The diversity of marine products is a significant source of possible bioactive chemical compounds with a wide range of potential medicinal applications. Marine organisms produce natural compounds and new drugs with unique properties are produced from these compounds. A lot of bioactive compounds with medicinal properties are extracted from marine invertebrates, including Peptides, Alkaloids, Terpenoids, Steroids. Thus, it can be concluded that marine ecosystems are endowed with natural resources that have a wide range of medicinal properties, and it is important to examine the therapeutic and pharmacological capabilities of these molecules. So, finding particular inhibitors of the COVID-19 in natural compounds will be extremely important. Natural ingredients, in this light, could be a valuable resource in the progression of COVID-19 therapeutic options. Controlling the immunological response in COVID-19 patients may be possible by addressing the PI3K/Akt pathway and regulating T cell responses. T cell effector activity can be improved by preventing anti-viral exhaustion by suppressing PI3K and Akt during the early anti-viral response. The diversity of marine life is a significant supply of potentially bioactive chemical compounds with a broad range of medicinal uses. In this study, some biologically active compounds from marine organisms capable of inhibiting PI3K/AKT and the possible therapeutic targets from these compounds in viral infection COVID-19 have been addressed.

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