How Frequent are Notified Severe Cutaneous Adverse Reactions to Fansidar®?

Stürchler, D; Mittelholzer, M L; Kerr, Lydia

doi:10.2165/00002018-199308020-00006

Cited by 40 publications

(17 citation statements)

References 38 publications

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“…This may, indeed, modify EPI attendance and should be addressed in implementation studies. Serious adverse events were rare, and the 3 cases of Stevens-Johnson syndrome were not conclusively attributable to SP treatment [32,33].…”

Section: Discussionmentioning

confidence: 98%

A Randomized Controlled Trial of Extended Intermittent Preventive Antimalarial Treatment in Infants

Kobbe¹,

Kreuzberg²,

Adjei

et al. 2007

Clinical Infectious Diseases

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Background. Intermittent preventive antimalarial treatment in infants (IPTi) with sulfadoxine-pyrimethamine reduces falciparum malaria and anemia but has not been evaluated in areas with intense perennial malaria transmission. It is unknown whether an additional treatment in the second year of life prolongs protection.Methods. A randomized, double-blinded, placebo-controlled trial with administration of sulfadoxine-pyrimethamine therapy at 3, 9, and 15 months of age was conducted with 1070 children in an area in Ghana where malaria is holoendemic. Participants were monitored for 21 months after recruitment through active follow-up visits and passive case detection. The primary end point was malaria incidence, and additional outcome measures were anemia, outpatient visits, hospital admissions, and mortality. Stratified analyses for 6-month periods after each treatment were performed.Results. Protective efficacy against malaria episodes was 20% (95% confidence interval [CI], 11%-29%). The frequency of malaria episodes was reduced after the first 2 sulfadoxine-pyrimethamine applications (protective efficacy, 23% [95% CI, 6%-36%] after the first dose and 17% [95% CI, 1%-30%] after the second dose). After the third treatment at month 15, however, no protection was achieved. Protection against the first or single anemia episode was only significant after the first IPTi dose (protective efficacy, 30%; 95% CI, 5%-49%). The number of anemia episodes increased after the last IPTi dose (protective efficacy, Ϫ24%; 95% CI, Ϫ50% to Ϫ2%).Conclusion. In an area of intense perennial malaria transmission, sulfadoxine-pyrimethamine-based IPTi conferred considerably lower protection than reported in areas where the disease is moderately or seasonally endemic. Protective efficacy is age-dependent, and extension of IPTi into the second year of life does not provide any benefit.

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Section: Discussionmentioning

confidence: 98%

A Randomized Controlled Trial of Extended Intermittent Preventive Antimalarial Treatment in Infants

Kobbe¹,

Kreuzberg²,

Adjei

et al. 2007

Clinical Infectious Diseases

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“…No considerable differences were revealed in the pattern of antibiotics in HMCs in large Russian cities. It is worth noting that "popular" antibiotics (e.g., trimethoprim-sulfamethoxazole [TMP-SMZ], chloramphenicol, and tetracycline) may cause serious adverse drug reactions [18][19][20][21][22][23].…”

Section: Discussionmentioning

confidence: 99%

The Inventory of Antibiotics in Russian Home Medicine Cabinets

Stratchounski

Andreeva

Ratchina

et al. 2003

Clinical Infectious Diseases

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The objective of this study was to inventory the stock of antimicrobials in the home medicine cabinets (HMCs) of the general population in Russia and to find out for which indications people report that they would use antibiotics without a physician's recommendation. The research was performed in 9 Russian cities by physicians who visited households. An inventory of antibiotics in HMCs was made, and respondents were asked about instances in which they would choose automedication with antibiotics. We found that 83.6% of families had antibiotics for systemic use in HMCs. The most common antibiotics in HMCs were trimethoprim-sulfamethoxazole (46.3% of HMCs), ampicillin (45.1%), chloramphenicol (32.7%), erythromycin (25.5%), and tetracycline (21.8%). The major indications for automedication with antibiotics were acute viral respiratory tract infections (12.3% of total indications), cough (11.8%), intestinal disorders (11.3%), fever (9%), and sore throat (6.8%). According to this study, antibiotics are widely stocked among the general population in Russia, and people use antibiotics in an uncontrolled and imprudent manner.

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“…Sulfadoxine/pyrimethamine (SP) is usually the next choice for treatment when chloroquine is no longer used, as it is also affordable, rarely associated with severe side effects, and can be given in a single dose. 1,2 Several African countries, mainly in eastern Africa, have introduced SP as a firstline treatment. Tanzania has done so recently, but at the time of the present study, chloroquine was still the first-line treatment.…”

Section: Introductionmentioning

confidence: 99%

Antipyretic, Parasitologic, and Immunologic Effects of Combining Sulfadoxine/Pyrimethamine With Chloroquine or Paracetamol for Treating Uncomplicated Plasmodium Falciparum Malaria

Hugosson

Tarimo²,

Troye‐Blomberg³

et al. 2003

The American Journal of Tropical Medicine and Hygiene

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Abstract. Sulfadoxine/pyrimethamine (SP) is increasingly used against malaria in sub-Saharan Africa because of chloroquine resistance. However, chloroquine may have a beneficial antipyretic effect. We therefore compared the combination of SP plus chloroquine, chloroquine alone, SP alone, and SP plus paracetamol in the treatment of uncomplicated Plasmodium falciparum malaria in 175 Tanzanian children (1−4 years old) in a randomized trial. Outcome variables were axillary temperatures every six hours, daily parasitemias, and serum levels of IgG antibodies to P. falciparum. Lower mean temperatures (6−48 hours) were achieved with SP plus chloroquine or paracetamol than with SP alone (P < 0.001) or chloroquine alone (P < 0.05). All three SP-treated groups showed high and similar parasite reduction (0−48 hours), whereas treatment with chloroquine alone was much less effective. Levels of IgG antibodies to P. falciparum increased significantly (P < 0.001) and similarly in the four treatment groups between days 0, 2. and 3. Thus, the addition of chloroquine or paracetamol to SP improved the clinical outcome, but did not affect the parasitologic response or antibody production.

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How Frequent are Notified Severe Cutaneous Adverse Reactions to Fansidar®?

Cited by 40 publications

References 38 publications

A Randomized Controlled Trial of Extended Intermittent Preventive Antimalarial Treatment in Infants

A Randomized Controlled Trial of Extended Intermittent Preventive Antimalarial Treatment in Infants

The Inventory of Antibiotics in Russian Home Medicine Cabinets

Antipyretic, Parasitologic, and Immunologic Effects of Combining Sulfadoxine/Pyrimethamine With Chloroquine or Paracetamol for Treating Uncomplicated Plasmodium Falciparum Malaria

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