“…Multiple biological and environmental confounders of PCE were assessed and controlled to isolate the effects of PCE and CM, including prenatal exposure to other substances such as alcohol (Larkby et al, 2011), tobacco (Maughan et al, 2004), and marijuana (Goldschmidt et al, 2000), elevated lead (≥10 μg/dL) levels (Lane et al, 2008; Min et al, 2009; Singer et al, 2008), ongoing caregiver postpartum substance abuse (Elkington et al, 2011) and psychological distress (Minnes et al, 2010), poor quality of the home environment (Singer et al, 2008; Min et al, 2014b), and violence exposure (Kobulsky et al, 2016; Frank et al, 2011). Further, lack of ecological resources and support from family, school, and the neighborhood/community which tend to confound with CM (Sippel et al, 2015), were also controlled. We hypothesized that adolescents with PCE would be more reactive to stress (more involuntary engagement and disengagement) and utilize coping strategies less effectively (less primary and secondary control and more disengagement) than adolescents without PCE.…”