How does low-level viremia affect the prognosis of patients with chronic hepatitis B?

Lee, Hye Won; Kim, Beom Kyung

doi:10.3350/cmh.2020.0121

Cited by 2 publications

(1 citation statement)

References 6 publications

(13 reference statements)

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“…The reimbursement criteria for entecavir or tenofovir were identical and did not change during the study period: serum HBV DNA levels of 20,000 IU/mL or greater for patients positive for hepatitis B e antigen (HBeAg); 2000 IU/mL or greater for patients negative for HBeAg; and alanine aminotransferase (ALT) levels of 80 U/mL or greater in the absence of cirrhosis. In the presence of cirrhosis, the criterion was HBV DNA levels of 2000 IU/mL or greater [ 22 , 23 ].…”

Section: Methodsmentioning

confidence: 99%

Association of Physical Activity with the Risk of Hepatocellular Carcinoma in Patients with Chronic Hepatitis B

Chun

Park

Lee

et al. 2021

Cancers

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Background and Aims: In the general population, previous studies reported that physical activity was associated with risk of hepatocellular carcinoma (HCC) development. However, it is unclear whether physical activity is associated with risk of HCC development in patients with chronic hepatitis B (CHB). We aimed to elucidate the association between physical activity and risk of HCC development in CHB patients. Methods: This nationwide cohort study involved treatment-naive patients with CHB (n = 9727) who started treatment with entecavir or tenofovir and answered self-reported questionnaires between January 2012 and December 2017, using data from the Korean National Health Insurance Service database. The primary endpoint was development of HCC. Multivariable Cox regression and competing risk analyses were used. Results: During a median follow-up of 3.1 years, cumulative HCC incidence rates were 8.3%. There was an inverse association between physical activity and the risk of HCC (p < 0.001). Patients with 1000–1500 metabolic equivalent task (MET)-min/week, compared to those without physical activity, showed a significantly lower risk of HCC in both patients without cirrhosis (adjusted hazard ratio [aHR] 0.66, p = 0.02) and patients with cirrhosis (aHR 0.61, p = 0.02). In patients who were younger (<60), male, without diabetes, and with high BMI, amounts of physical activity of 1000–1500 MET-min/week showed an inverse association with the risk of HCC (aHR 0.65, 0.63, 0.65, and 0.64, respectively, all p < 0.05). Conclusion: Physical activity was significantly associated with a low risk of HCC in CHB patients treated with entecavir or tenofovir.

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Section: Methodsmentioning

confidence: 99%