'The identification of potential breakthroughs before they happen' is a vague data analysis problem and 'the scientific literature' is a massive, complex dataset. Hence QHS for MTS might seem to be prototypical of the data miner's lament: 'Here's some data we have. . . can you find something interesting?' Nonetheless, the problem is real and important, and we develop an innovative statistical approach thereto-not a final etched-in-stone approach, but perhaps the first complete quantitative methodology explicitly addressing QHS for MTS.