How do mammillary body inputs contribute to anterior thalamic function?

Dillingham, Christopher M.; Frizzati, Aura; Nelson, Andrew John Dudley; Vann, Seralynne Denise

doi:10.1016/j.neubiorev.2014.07.025

Cited by 82 publications

(97 citation statements)

References 135 publications

(253 reference statements)

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“…They also exert an influence through reciprocal connections with the different regions of the retrosplenial cortex, thereby making major contributions to serial connections across the extended circuit. An excellent summary of these and other ATN connections was provided by Jankowski et al (2013) see also, Dillingham et al (2014). Rather than a purely passive role, however, the ATN may provide a strategic influence on the hippocampal system, perhaps on the basis of the unique modulation made on the ATN by its connections with the MB and brainstem tegmental nuclei see Fig.…”

Section: The Anterior Thalamic Nuclei (Atn)mentioning

confidence: 98%

“…This idea of an extended hippocampal system with the ATN as a nodal point in the exchange of both cortical and subcortical information relevant to episodic memory receives considerable support from anatomical descriptions of the neural connections of the ATN Dillingham et al, 2014;Jankowski et al, 2013;Wright et al, 2013). The three subnuclei of the ATN have a substantial number of reciprocal connections with the subicular cortex of the hippocampus and with the prefrontal cortex.…”

Section: The Anterior Thalamic Nuclei (Atn)mentioning

confidence: 99%

“…Recognised by clinical studies long before attention became focused on the hippocampal formation and medial temporal lobe, this subcortical pathology is increasingly viewed as an important field of study if we are to achieve a full understanding of the neuroanatomical basis of memory, and episodic memory in particular (Aggleton, 2014;Carlesimo et al, 2014;Child and Benarroch, 2013;Kopelman et al, 2009). Several thalamic structures within the diencephalon have been implicated, most commonly the mediodorsal nucleus (MD), the midline and intralaminar nuclei (ILN), the anterior thalamic nuclei (ATN), and the fibre pathways associated with these nuclei Dillingham et al, 2014;Mitchell and Chakraborty, 2013;Pergola and Suchan, 2013;Savage et al, 2012;. It is likely that human cases of amnesia involve damage to multiple thalamic sites and fibre tracts, some of which may affect many cognitive processes in addition to their influence on memory (Carlesimo et al, 2014;Carrera and Bogousslavsky, 2006;Cipolotti et al, 2008;Mennemeier et al, 1992;Nishio et al, 2014).…”

Section: Q3mentioning

confidence: 99%

“…One of the most interesting consequences of ATN dysfunction in rats, discovered by John Aggleton, Seralynne Vann and their colleagues, is that ATN and mammillothalamic tract lesions (and lesions to the ventral tegmental nucleus of Gudden, the brain stem nucleus that projects to the MB) produce a dramatic, enduring and exacerbating reduction in the expression of immediate-early gene products (IEG), c-Fos and Zif268, in the retrosplenial cortex (Fig. 5) (Aggleton, 2008;Albasser et al, 2007;Amin et al, 2010;Dumont et al, 2012;Jenkins et al, 2002a,b;Jenkins et al, 2004;Poirier and Aggleton, 2009;Vann and Albasser, 2009;Vann et al, 2014).…”

Section: Recovery Using Cerebrolysin a Neurotrophic Drugmentioning

confidence: 99%

“…An extension of this idea, which has received less attention, is the suggestion that the ATN primarily influence the hippocampus, rather than vice versa, through various direct and indirect routes Dillingham et al, 2014;Vann, 2010;Fig. 2).…”

Section: Recovery Of Neuronal Microintegrity In Hippocampal Ca1mentioning

confidence: 99%

See 4 more Smart Citations

Anterior thalamic nuclei lesions and recovery of function: Relevance to cognitive thalamus

Dalrymple‐Alford

Harland

Loukavenko

et al. 2015

Neuroscience & Biobehavioral Reviews

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Section: The Anterior Thalamic Nuclei (Atn)mentioning

confidence: 98%

Section: The Anterior Thalamic Nuclei (Atn)mentioning

confidence: 99%

Section: Q3mentioning

confidence: 99%

Section: Recovery Using Cerebrolysin a Neurotrophic Drugmentioning

confidence: 99%

Section: Recovery Of Neuronal Microintegrity In Hippocampal Ca1mentioning

confidence: 99%

See 3 more Smart Citations

Anterior thalamic nuclei lesions and recovery of function: Relevance to cognitive thalamus

Dalrymple‐Alford

Harland

Loukavenko

et al. 2015

Neuroscience & Biobehavioral Reviews

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Connections of the laterodorsal tegmental nucleus with the habenular‐interpeduncular‐raphe system

Bueno

Lima

Souza

et al. 2019

J of Comparative Neurology

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The laterodorsal tegmental nucleus (LDTg) is a hindbrain cholinergic cell group thought to be involved in mechanisms of arousal and the control of midbrain dopamine cells. Nowadays, there is increasing evidence that LDTg is also engaged in mechanisms of anxiety/fear and promotion of emotional arousal under adverse conditions. Interestingly, LDTg appears to be connected with other regulators of aversive motivational states, including the lateral habenula (LHb), medial habenula (MHb), interpeduncular nucleus (IP), and median raphe nucleus (MnR). However, the circuitry between these structures has hitherto not been systematically investigated. Here, we placed injections of retrograde or anterograde tracers into LDTg, LHb, IP, and MnR.We also examined the transmitter phenotype of LDTg afferents to IP by combining retrograde tracing with immunofluorescence and in situ hybridization techniques.We found LHb inputs to LDTg mainly emerging from the medial division of the LHb (LHbM), which also receives axonal input from LDTg. The bidirectional connections between IP and LDTg displayed a lateralized organization, with LDTg inputs to IP being predominantly GABAergic or cholinergic and mainly directed to the contralateral IP. Moreover, we disclosed reciprocal LDTg connections with structures involved Abbreviations: 3V, third ventricle; 4V, fourth ventricle; 4n, trochlear nerve; A13, A13 dopamine cell group; ac, anterior commissure; AcbRP, nucleus accumbens, rostral pole; AD, anterodorsal thalamic nucleus; AID, agranular insular cortex, dorsal part; AIV, agranular insular cortex, ventral part; AM, anteromedial thalamic nucleus; BAC, bed nucleus of the anterior commissure; BST, bed nucleus of the stria terminalis; Cg1, cingulate cortex 1in the modulation of hippocampal theta rhythm including MnR, nucleus incertus, and supramammillary nucleus. Our findings indicate that the habenula is linked with LDTg either by direct reciprocal projections from/to LHbM or indirectly via the MHb-IP axis, supporting a functional role of LDTg in the regulation of aversive behaviors, and further characterizing LHb as a master controller of ascending brainstem state-setting modulatory projection systems.

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Focal impaired awareness seizures in a rodent model: A functional anatomy

Adotevi

2021

Epilepsia Open

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Objective: Patients with temporal lobe epilepsy (TLE) frequently report debilitating comorbidities such as memory impairments, anxiety, and depression. An extensive neuronal network generates epileptic seizures and associated comorbidities, but a detailed description of this network is unavailable, which requires the generation of neuronal activation maps in experimental animals. Methods:We recorded electrographic seizures from the hippocampi during a kindling-evoked focal impaired awareness seizure with observed freezing, facial twitching, and involuntary head bobbing. We mapped seizure circuits activated during these seizures by permanently tagging neurons through activity-induced immediate early genes, combined with immunohistochemical approaches.Results: There was bilateral activation of circuits necessary for memory consolidation, including the hippocampal complex, entorhinal cortex, cingulate gyrus, retrosplenial cortex, piriform cortex, and septohippocampal complex in kindled animals compared with unstimulated awake behaving mice. Neuronal circuits in the ventral hippocampus, amygdala, and anterior cingulate cortex, which regulate the stress response of hypothalamic-pituitary-adrenal axis, were also markedly activated during a focal impaired awareness seizure.Significance: This study highlights neuronal circuits preferentially activated during a focal awareness impaired seizure in a rodent model. Many of the seizure-activated neuronal circuits are critical modulators of memory consolidation and long-term stress/depression response. The hijack of these memory and depression regulatory systems by a focal seizure could account for the frequent reports of comorbidities such as memory impairment and depression in many TLE patients.

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How do mammillary body inputs contribute to anterior thalamic function?

Cited by 82 publications

References 135 publications

Anterior thalamic nuclei lesions and recovery of function: Relevance to cognitive thalamus

Anterior thalamic nuclei lesions and recovery of function: Relevance to cognitive thalamus

Connections of the laterodorsal tegmental nucleus with the habenular‐interpeduncular‐raphe system

Focal impaired awareness seizures in a rodent model: A functional anatomy

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