2019
DOI: 10.1002/cne.24729
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Connections of the laterodorsal tegmental nucleus with the habenular‐interpeduncular‐raphe system

Abstract: The laterodorsal tegmental nucleus (LDTg) is a hindbrain cholinergic cell group thought to be involved in mechanisms of arousal and the control of midbrain dopamine cells. Nowadays, there is increasing evidence that LDTg is also engaged in mechanisms of anxiety/fear and promotion of emotional arousal under adverse conditions. Interestingly, LDTg appears to be connected with other regulators of aversive motivational states, including the lateral habenula (LHb), medial habenula (MHb), interpeduncular nucleus (IP… Show more

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Cited by 26 publications
(30 citation statements)
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References 193 publications
(294 reference statements)
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“…In addition, mPOA MCH neurones did not colocalise with VGLUT2 cell bodies, a well‐established marker of glutamatergic neurones in the hypothalamus (Figure B). VGLUT3‐expressing cell bodies can be observed in several brain regions, particularly in the brainstem . In the preoptic area, VGLUT3 expression was basically restricted to axon terminals, many of them making apparent contacts with MCH neurones (Figure C).…”
Section: Resultsmentioning
confidence: 99%
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“…In addition, mPOA MCH neurones did not colocalise with VGLUT2 cell bodies, a well‐established marker of glutamatergic neurones in the hypothalamus (Figure B). VGLUT3‐expressing cell bodies can be observed in several brain regions, particularly in the brainstem . In the preoptic area, VGLUT3 expression was basically restricted to axon terminals, many of them making apparent contacts with MCH neurones (Figure C).…”
Section: Resultsmentioning
confidence: 99%
“…VGLUT1 was not studied because this transporter is poorly expressed in the hypothalamus; however, we cannot rule out the possibilty that VGLUT1 mediates glutamate release in mPOA MCH neurones. Additionally, VGLUT3 antibody labels predominantly synaptic terminals in the hypothalamus, although cell bodies can be observed in the paraventricular nucleus of the hypothalamus (J. Donato, unpublished data) and in the brainstem …”
Section: Discussionmentioning
confidence: 99%
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“…These authors also specified that most DR inputs to IP are provided by GABAergic neurons in the lateral wings of the DR. Interestingly, besides DR/MnR, two other mesopontine state‐setting modulatory nuclei, the LDTg and nucleus incertus (NI; Goto, Swanson, & Canteras, 2001), are robustly interconnected with IP. As revealed by conventional and viral tracing studies, there are topographically ordered, mostly GABAergic, bidirectional connections between LDTg and IP (Bueno et al, 2019; Cornwall, Cooper, & Phillipson, 1990; Groenewegen et al, 1986; Lima et al, 2017; Quina et al, 2017). The mostly GABAergic NI, which is situated just caudal to DRC in the floor of the fourth ventricle, is a relatively new player in arousal (Goto et al, 2001; Ma et al, 2017; Ryan, Ma, Olucha‐Bordonau, & Gundlach, 2011).…”
Section: Indirect Outputs Of the Mhb To State‐setting Neuromodulatorymentioning
confidence: 99%